Results 111 to 120 of about 55,191 (217)

Colistin resistance development following colistin-meropenem combination therapy versus colistin monotherapy in patients with infections caused by carbapenem-resistant organisms

, 2020
Background. We evaluated whether carbapenem-colistin combination therapy reduces the emergence of colistin resistance, compared to colistin monotherapy, when given to patients with infections due to carbapenem-resistant Gram-negative organisms.
Bernardo, M., Altunin, S., Bertolino, L., Koppel, F., Pafundi, P.C., Elbaz, M., Giurazza, R., Schwartz, D., Nutman, A., Giuffre, G., Mouton, J., Friberg, L., Antoniadou, A., Paul, M., Skiada, A., Benattar, Y.D., Daitch, V., Neuberger, A., Babich, T., Murino, P., Zampino, R., Andria, N., Raines, M., Kotsaki, A., Deliolanis, I., Atamna, H., Carmeli, Y., Cuccurullo, S., Dickstein, Y., Corcione, A., Durante-Mangoni, E., Kristoffersson, A., Bitterman, R., Karban, A., Daikos, G.L., Rognås, V., Adler, A., Andini, R., Iossa, D., Eliakim-Raz, N., Levi, I., Zak-Doron, Y., Rakovitsky, N., Friberg, L.E., Petersiel, N., Cavezza, G., Yahav, D., Galdo, M., Pavleas, I., Lellouche, J., the AIDA Study Group, Stern, A., Theuretzbacher, U., Mouton, J.W., Zusman, O., Leibovici, L., Zayyad, H., Cristinziano, A.   +57 more
core   +1 more source

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP‐Like Phenotype After Glaucoma Filtration Surgery

Aging Cell, Volume 25, Issue 9, September 2026.
Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura, Tomokazu Fujimoto, Satoshi Iraha, Kei‐Ichiro Yasunaga, Miyuki Inoue‐Mochita, Naofumi Funagura, Shunsuke Tanigawa, Daisuke Kurotaki, Tomoaki Koga, Fumika Watanabe‐Kitamura, Utako Tsutsumi‐Kuroda, Mitsuyoshi Nakao, Toshihiro Inoue   +12 more
wiley   +1 more source

Comparative effectiveness and mortality of colistin monotherapy versus colistin-fosfomycin combination therapy for the treatment of carbapenem-resistant Enterobacteriaceae (CRE) infections: A propensity score analysis

Journal of Infection and Public Health
Background: Carbapenem-resistant Enterobacteriaceae (CRE) infections pose a significant threat to global health due to limited treatment options and high mortality rates.
Wasan Katip, Ajaree Rayanakorn, Peninnah Oberdorfer, Puntapong Taruangsri, Teerapong Nampuan, Siriporn Okonogi   +5 more
doaj   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, Volume 73, Issue 6, Page 516-527, September 2026.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Machine learning assisted Raman spectroscopy to discern the markers associated with colistin Resistance [PDF]

Raman spectroscopy (RS) is rapidly becoming a key analytical tool for a wide range of microbiology applications. In combination with diverse machine learning methods, RS has demonstrated potentials to be translated in form of a culture-free, rapid, and ...
Cebajel, Tanan, Nilkamal, Mahanta, Surya Pratap, Singh, Dimple, Saikia, Basavraj, Hungund, Dhananjaya, G   +5 more
core   +1 more source

β,β-Dimethylacrylalkannin Restores Colistin Efficacy Against mcr- and TCS-Mediated Resistant Gram-Negative Bacteria via Membrane Disturbance

Antibiotics
Background: The reintroduction of colistin has led to the rapid emergence of colistin-resistant strains, significantly diminishing its therapeutic efficacy. This presents a need for effective adjuvants to restore colistin efficacy.
Yongqing Liu, Huangwei Song, Muchen Zhang, Junyao Jiang, Yan Zhang, Jian Xu, Xi Xia, Shangshang Qin, Jianzhong Shen, Yang Wang, Dejun Liu   +10 more
doaj   +1 more source

Effectiveness of treatment with nebulized colistin in patients with COPD

, 2017
Nuria Bruguera-Avila,1–3 Alicia Marin,3–5 Ignasi Garcia-Olive,3–5 Joaquim Radua,6–8 Cristina Prat,4,9,10 Montserrat Gil,3 Juan Ruiz-Manzano2–5 1Department of Medicine, Hospital Sant Jaume de Calella, Calella, Barcelona ...
Garcia-Olive I, Radua J, Bruguera-Avila N, Marín A, Ruiz-Manzano J, Gil M, Prat C   +6 more
core  

Frequency of colistin and fosfomycin resistance in carbapenem-resistant Enterobacteriaceae from a tertiary care hospital in Karachi

, 2017
Salima Qamar, Najma Shaheen, Sadia Shakoor, Joveria Farooqi, Kauser Jabeen, Rumina Hasan Clinical Microbiology, Department of Pathology And Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan Introduction ...
Farooqi J, Hasan R, Jabeen K, Shakoor S, Qamar S, Shaheen N   +5 more
core  

Colistin Resistance Mechanisms and Molecular Epidemiology of Enterobacter cloacae Complex Isolated from a Tertiary Hospital in Shandong, China [PDF]

Zaifeng Si,1,2,* Shengmei Zhao,3,* Yingying Hao,3 Qian Wang,3 Yanfa Zhong,2 Yue Liu,3 Ran Chen,3 Yan Jin,3 Zhiming Lu1,3 1Department of Clinical Laboratory, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan ...
Liu Y, Zhao S, Wang Q, Si Z, Lu Z, Hao Y, Zhong Y, Jin Y, Chen R   +8 more
core  

Nitroxoline as an antimicrobial synergist reverses colistin resistance in multidrug-resistant Escherichia coli

iScience
Summary: Colistin is a crucial drug for treating multidrug-resistant (MDR) Escherichia coli infections. The emergence and bacterial transmission of the colistin-resistant gene mcr-1 have substantially diminished its therapeutic efficacy.
Hao Wang, Jie He, Hao Li, Chengming Li, Muhammad Inam, Jianfeng Wang, Huifeng Dong, Dingkuo Liu, Fang Liu, Jingrui Chen, Yu Jia, Yunhang Gao, Lingcong Kong, Hongxia Ma   +13 more
doaj   +1 more source