Results 61 to 70 of about 76,292 (274)

Circumventing colistin resistance by combining colistin and antimicrobial peptides to kill colistin-resistant and multidrug-resistant Gram-negative bacteria

Journal of Global Antimicrobial Resistance, 2020
Objectives: Colistin is a ‘last-line’ antibiotic used to treat multidrug-resistant Gram-negative bacteria, but colistin resistance has emerged. Colistin normally binds to the lipid A moiety on the bacterial outer membrane, where it then destroys the ...
Kaitlin S. Witherell, Jason Price, Ashok D. Bandaranayake, James Olson, Douglas R. Call   +4 more
doaj   +1 more source

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +4 more sources

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains

Medical Science and Discovery, 2018
Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment.
openaire   +3 more sources

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics [PDF]

, 2019
Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment.
Coenye, Tom, Crabbé, Aurélie, Daled, Simon, Deforce, Dieter, Dhaenens, Maarten, Ostyn, Lisa, Rigauts, Charlotte, Risseeuw, Martijn, Staelens, Sorien, Van Acker, Heleen, Van Calenbergh, Serge   +10 more
core   +6 more sources

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

Advanced Science, EarlyView.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source

Colistin Susceptibility and Plasmid Mediated mcr-1 Gene Prevalance among Multi Drug Resistant Clinical Isolates of Escherichia coli, Kebsiella pneumoniae and Pseudomonas aeruginosa - A Hospital Based Cross Sectional Study

Journal of Medical Sciences and Health
Introduction: The treatment options for multi drug resistant (MDR) and extensively drug resistant (XDR) Gram negative bacterial infections are limited. Colistin based combination therapy remains the last option for such infections.
Nivetha Subramanian, Mangaiyarkarasi Thiyagarajan, Udhayasankar Ranganathan, Sunil S Shivekar, R Gopal   +4 more
doaj   +1 more source

Heterogeneous Colistin-Resistance Phenotypes Coexisting in Stenotrophomonas maltophilia Isolates Influence Colistin Susceptibility Testing

Frontiers in Microbiology, 2018
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed.
Sònia Martínez-Servat, Sònia Martínez-Servat, Daniel Yero, Daniel Yero, Pol Huedo, Pol Huedo, Roser Marquez, Gara Molina, Xavier Daura, Xavier Daura, Isidre Gibert, Isidre Gibert   +11 more
doaj   +1 more source

Colistin Susceptibility in Companion Animal-Derived Escherichia coli, Klebsiella spp., and Enterobacter spp. in Japan: Frequent Isolation of Colistin-Resistant Enterobacter cloacae Complex

Frontiers in Cellular and Infection Microbiology, 2022
Transmission of colistin-resistant Enterobacterales from companion animals to humans poses a clinical risk as colistin is a last-line antimicrobial agent for treatment of multidrug-resistant Gram-negative bacteria including Enterobacterales.
Toyotaka Sato, Toyotaka Sato, Toyotaka Sato, Kazuki Harada, Masaru Usui, Shin-ichi Yokota, Motohiro Horiuchi, Motohiro Horiuchi   +7 more
doaj   +1 more source

In vitro evaluation of the interaction of dextrin-colistin conjugates with bacterial lipopolysaccharide. [PDF]

, 2016
Dextrin-colistin conjugates have been developed with the aim of reducing clinical toxicity associated with colistin and improving targeting to sites of bacterial infection. This study investigated the in vitro ability of these dextrin-colistin conjugates
Beck, Konrad, Cattoz, Beatrice N., Ferguson, Elaine L., Griffiths, Peter, Roberts, Jessica L., Schweins, Ralf, Thomas, David W.   +6 more
core   +3 more sources