Results 91 to 100 of about 57,221 (225)

Plasmid-mediated colistin resistance: an additional antibiotic resistance menace [PDF]

Clinical Microbiology and Infection, 2016
The increasing trend in antibiotic resistance continues to threaten global health due to the limited pipeline of new antibiotics. Multidrug resistance in Gram-negative bacteria is of special concern because it may associate resistance to the three main classes of antibiotics in single isolates.
Nordmann, Patrice, Poirel, Laurent
openaire   +3 more sources

Prevalence of colistin-resistant Enterobacteriaceae isolated from clinical samples in Africa: a systematic review and meta-analysis

BMC Infectious Diseases
Background Antimicrobial resistance among Enterobacteriaceae poses a significant global threat, particularly in developing countries. Colistin, a critical last-resort treatment for infections caused by carbapenem-resistant and multidrug-resistant strains,
Yalewayker Gashaw, Zelalem Asmare, Mitkie Tigabie, Asefa Sisay, Ermias Getatachew, Selamyhun Tadesse, Getachew Bitew, Agenagnew Ashagre, Tadesse Misganaw, Muluken Gashaw, Woldeteklehaymanot Kassahun, Zelalem Dejazimach, Abdu Jemal, Solomon Gedfie, Getinet Kumie, Marye Nigatie, Wagaw Abebe, Atitegeb Abera Kidie, Biruk Beletew Abate, Melese Abate Reta, Baye Gelaw   +20 more
doaj   +1 more source

Chemical agents to control biofilm formation in step 1 of care—Toothpastes and mouthwashes/concepts and challenges

Periodontology 2000, EarlyView.
Abstract Maintaining optimal oral hygiene is important for overall oral care, ensuring the well‐being of teeth and their surrounding tissues. In addition, it promotes fresh breath and a pleasing smile. A key element of oral self‐care is the daily use of toothpaste during regular brushing.
Maud Joosstens, Cees Valkenburg, Fridus Van der Weijden   +2 more
wiley   +1 more source

Prevalence of colistin-resistant Escherichia coli in foods and food-producing animals through the food chain: A worldwide systematic review and meta-analysis

Heliyon
The purpose of this systematic review and meta-analysis was to summarize the available scientific evidence on the prevalence of colistin-resistant Escherichia coli strains isolated from foods and food-producing animals, the mobile colistin-resistant ...
Florencia Aylen Lencina, Matías Bertona, María Angeles Stegmayer, Carolina Raquel Olivero, Laureano Sebastián Frizzo, Jorge Alberto Zimmermann, Marcelo Lisandro Signorini, Lorena Paola Soto, María Virginia Zbrun   +8 more
doaj   +1 more source

Characteristics and genomic epidemiology of colistin-resistant Enterobacterales from farmers, swine, and hospitalized patients in Thailand, 2014–2017

BMC Infectious Diseases, 2023
Background Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics.
Adhiratha Boonyasiri, Lauren M. Brinkac, Elita Jauneikaite, Richard C. White, Chris Greco, Chakkraphong Seenama, Teerawit Tangkoskul, Kevin Nguyen, Derrick E. Fouts, Visanu Thamlikitkul   +9 more
doaj   +1 more source

Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli [PDF]

, 2017
The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gramnegative bacteria ...
Bush, Karen, Li, Hui, Liu, Zhihai, Shen, Jianzhong, Shen, Yingbo, Shen, Zhangqi, Walsh, Timothy, Wang, Shaolin, Wang, Yang, Yin, Wenjuan, Zhang, Rong   +10 more
core   +2 more sources

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double‐Blinded, Controlled ‘Split Body’ Clinical Trial

Veterinary Dermatology, EarlyView.
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron, Darko Stefanovski, Youwen You, Rachel Proctor, Donna Watson, Julie Randall, Christine L. Cain   +6 more
wiley   +1 more source

Understanding Responsible Antimicrobial Practices and Antimicrobial Resistance: A Cross‐Sectional Study of Farmers in Rangpur, Bangladesh

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Surveying 537 farmers in Bangladesh revealed widespread high‐risk antibiotic use, including misuse of critically important antimicrobials and treatment of non‐bacterial diseases. The findings highlight a major knowledge‐practice gap and emphasize the need for improved diagnostics, stronger regulation, and a One Health‐based antimicrobial stewardship ...
Anju Man Ara, Farjana Boby, Mohsin Taluckder, Md. Shahiduzzaman   +3 more
wiley   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258

Journal of Microbiology, Immunology and Infection, 2017
Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.
Kocsis, Béla, Kádár, Béla, Tóth, Ákos, Fullár, Alexandra, Szabó, Dóra   +4 more
openaire   +4 more sources