Results 71 to 80 of about 33,514 (181)

Nanoparticle‐Based Strategies to Combat Multidrug‐Resistant Bacteria: Mechanisms, Applications, and Future Perspectives

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Nanobiotics offer a promising strategy to combat antimicrobial resistance (AMR) and multidrug‐resistant (MDR) bacteria. Nanoparticles overcome traditional resistance mechanisms through unique physicochemical properties and multivalent interactions.
Akmal Zubair, Syeda Zaira Batool, Mohamed H. Helal, Naila Afghan   +3 more
wiley   +1 more source

MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258

Journal of Microbiology, Immunology and Infection, 2017
Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.
Kocsis, Béla, Kádár, Béla, Tóth, Ákos, Fullár, Alexandra, Szabó, Dóra   +4 more
openaire   +4 more sources

MCR-1 Confers Cross-Resistance to Bacitracin, a Widely Used In-Feed Antibiotic

mSphere, 2018
Extensive use of colistin in food animals is deemed a major driving force for the emergence and transmission of mcr-1. However, a non-colistin usage factor(s) contributing to mobile colistin resistance may also exist in animal production systems.
Fuzhou Xu, Ximin Zeng, Atsushi Hinenoya, Jun Lin   +3 more
doaj   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, Volume 50, Issue 6, Page 1409-1450, June 2026.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double‐Blinded, Controlled ‘Split Body’ Clinical Trial

Veterinary Dermatology, Volume 37, Issue 3, Page 427-436, June 2026.
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron, Darko Stefanovski, Youwen You, Rachel Proctor, Donna Watson, Julie Randall, Christine L. Cain   +6 more
wiley   +1 more source

Pyrazolyl–Pyridine Ruthenium Complexes: A New Metallic Line of Defense Against Acinetobacter baumannii

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
Ruthenium(II) (Ru(II)) pyrazolyl–pyridine half‐sandwich complexes (C1–C6) were synthesized and structurally characterized as prospective metalloantibiotics. Screening through the Community for Open Antimicrobial Drug Discovery (CO‐ADD) revealed selective activity against Acinetobacter baumannii, with favorable cytotoxicity profiles. Biophysical studies
M. Cassiem Joseph, Sheldon Sookai, Monika Nowakowska, Rotondwa Mphephu, Angela M. Kavanagh, Johannes Zuegg, Mark A. T. Blaskovich, Andrew J. Swarts   +7 more
wiley   +1 more source

Colistin-resistant Pseudomonas aeruginosa clinical strains with defective biofilm formation

GMS Hygiene and Infection Control, 2019
Aim: Colistin is the only effective antibiotic in some cases of resistance to all tested antibiotics, even carbapenem. On the other hand, biofilm formation is one of the antibiotic resistance mechanisms in this bacterium.
Azimi, Leila, Lari, Abdolaziz Rastegar
doaj   +1 more source

Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli

Journal of Global Antimicrobial Resistance
Objectives: The mechanisms underlying chromosomally encoded colistin resistance in Escherichia coli remain insufficiently investigated. In this study, we investigated the contribution of various pmrB mutations from E.
Jung-Chung Lin, Leung-Kei Kristopher Siu, Feng-Yee Chang, Ching-Hsun Wang   +3 more
doaj   +1 more source

Intrinsic colistin resistance [PDF]

The Lancet Infectious Diseases, 2016
Kai, Zhou, Vincent, Cattoir, Yonghong, Xiao   +2 more
openaire   +2 more sources

Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains

Medical Science and Discovery, 2018
Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment.
openaire   +3 more sources