Results 81 to 90 of about 2,359,106 (231)

Chemical agents to control biofilm formation in step 1 of care—Toothpastes and mouthwashes/concepts and challenges

Periodontology 2000, EarlyView.
Abstract Maintaining optimal oral hygiene is important for overall oral care, ensuring the well‐being of teeth and their surrounding tissues. In addition, it promotes fresh breath and a pleasing smile. A key element of oral self‐care is the daily use of toothpaste during regular brushing.
Maud Joosstens, Cees Valkenburg, Fridus Van der Weijden   +2 more
wiley   +1 more source

Identification of Genetic Alterations Associated with Acquired Colistin Resistance in Klebsiella pneumoniae Isogenic Strains by Whole-Genome Sequencing

, 2020
The present study was undertaken to find novel genes associated with colistin resistance in Klebsiella pneumoniae. Five colistin-resistant mutants were derived from four colistin-susceptible parental K.
Myeongjin Choi, Kwan Soo Ko
core   +1 more source

Expression of transcriptional regulator mgrB is enhanced in colistin-resistant Klebsiella pneumoniae: A report from India

Journal of Microbiology and Infectious Diseases
Background: Colistin is regarded as the final option for treating Gram-negative bacteria that are resistant to several drugs. A common resistance mechanism for colistin in Klebsiella pneumoniae is mgrB gene inactivation.
Rajkumari Elizabeth, Nikita Karmakar, Jayalaxmi Wangkheimayum, Bhaskar Jyoti Das, Dr.Debadatta Dhar (Chanda), Dr. Amitabha Bhattacharjee   +5 more
doaj   +1 more source

Bacterial Agents and Their Multidrug‐Resistance Profile Among Patients Suspected of Bacterial Infections in Hakim Gizaw Hospital, Debre Berhan, Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Antimicrobial resistance is a global threat. Bacteria showed higher resistance in Ethiopia, and up‐to‐date data on it is urgently required for effective interventions. This study aimed to determine occurrence of multi‐drug‐resistant (MDR) bacterial isolates among patients presented to Hakim Gizaw Hospital (HGH).
Tizazu Zenebe Zelelie, Ermias Endewunetu, Yosef Temesgen, Demissew Shenkute Gebreyes, Zenawork Sahile, Biniam Mekonnen, Getachew Bizuneh, Asrat Berihun, Berhanu Yitayew   +8 more
wiley   +1 more source

Colistin-degrading proteases confer collective resistance to microbial communities during polymicrobial infections

Microbiome, 2022
Background The increasing prevalence of resistance against the last-resort antibiotic colistin is a significant threat to global public health. Here, we discovered a novel colistin resistance mechanism via enzymatic inactivation of the drug and proposed ...
Do-Hoon Lee, Ju-Hee Cha, Dae-Wi Kim, Kihyun Lee, Yong-Seok Kim, Hyo-Young Oh, You-Hee Cho, Chang-Jun Cha   +7 more
doaj   +1 more source

Molecular Mechanisms of Colistin Resistance Among Klebsiella Pneumoniae Strains [PDF]

, 2019
Background: The increasing rate of infections caused by multiple drug resistant gram-negative bacteria has led to resuscitation of colistin. As a result, colistin resistance, mainly among Klebsiella pneumoniae strains has also been increased.
DEMİRCİ, MEHMET, Kucukbasmaci, Omer, Gungordu-Dalar, Zeynep, Borsa, Bari S. A., Karabiyik, Goktug, Aygun, Gokhan, Borsa, Barış Ata, Karabıyık, Göktuğ, Küçükbasmacı, Ömer   +8 more
core   +1 more source

Development of colistin resistance via heteroresistance modeling in : A diagnostic study [PDF]

Precision and Future Medicine
Purpose Colistin heteroresistance mediates the failure of antibiotic treatments, is prone to lead to colistin resistance, and has been frequently reported in Klebsiella pneumoniae.
Jungyu Seo, Kwan Soo Ko
doaj   +1 more source

Machine Learning–Augmented Precision Dosing: Integrating Pharmacokinetic Modeling With Clinical Decision Support

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 11, November 2026.
ABSTRACT Inter‐individual variability in drug exposure can lead to ineffective therapy or toxicity, particularly in vulnerable patients. Routine model‐informed precision dosing (MIPD) relies mainly on population pharmacokinetic (PopPK) models, Bayesian forecasting, and therapeutic drug monitoring (TDM).
Yunmeng Pang, Bingqi Zhang, Zhiqiu He, Yuliu Li, Jiaxin Yu, Wei Zuo   +5 more
wiley   +1 more source

Triazole Derivatives as Potential MCR-1 Inhibitors: A Promising Approach to Overcome Colistin Resistance [PDF]

BACKGROUND/AIMS: Colistin, a last-resort antibiotic, is crucial in treating multidrug-resistant Gram-negative infections. However, the rise of colistin resistance, particularly due to plasmid-mediated MCR-1 genes, poses a significant challenge.
Emine Erdağ, Cenk Serhan Özverel, Cemile Bağkur   +2 more
core   +1 more source

Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii. [PDF]

, 2019
The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections.
Baker, S, Chau, NVV, Hoang, NTD, Hadfield, J, Nguyen Van Vinh Chau,, Khanh, Nhu Nguyen Thi, Boinett, Christine J., Chau, Nguyen Van Vinh, Parkhill, J, Holt, Kathryn E., Mayho, M, Langridge, GC, Thwaites, Guy E, Langridge, Gemma C., Hawkey, Jane, Campbell, James I, Khanh, NNT, Boinett, CJ, Dordel, Janina, Nhu Tran Do Hoang,, Holt, Kathryn E, Nguyen Phu Huong Lan,, Thwaites, Guy E., Thomson, Nicholas R, Thomson, Nicholas R., Cain, AK, Mayho, Matthew, Lan, NPH, Campbell, James, Pham, Thanh Duy, Cain, Amy K, Holt, KE, Boinett, Christine J, Hadfield, James, Langridge, Gemma C, Hawkey, J, Campbell, JI, Thanh, Duy Pham, Do Hoang, Nhu Tran, Nhu, Nguyen Thi Khanh Nhu, Lan, Nguyen Phu Huong, Cain, Amy K., Campbell, James I., Thanh, DP, Dordel, J, Parkhill, Julian, Thwaites, GE, Thomson, NR, Baker, Stephen   +48 more
core   +2 more sources