Results 81 to 90 of about 2,218,812 (219)

Expression of transcriptional regulator mgrB is enhanced in colistin-resistant Klebsiella pneumoniae: A report from India

Journal of Microbiology and Infectious Diseases
Background: Colistin is regarded as the final option for treating Gram-negative bacteria that are resistant to several drugs. A common resistance mechanism for colistin in Klebsiella pneumoniae is mgrB gene inactivation.
Rajkumari Elizabeth, Nikita Karmakar, Jayalaxmi Wangkheimayum, Bhaskar Jyoti Das, Dr.Debadatta Dhar (Chanda), Dr. Amitabha Bhattacharjee   +5 more
doaj   +1 more source

Development of colistin resistance via heteroresistance modeling in : A diagnostic study [PDF]

Precision and Future Medicine
Purpose Colistin heteroresistance mediates the failure of antibiotic treatments, is prone to lead to colistin resistance, and has been frequently reported in Klebsiella pneumoniae.
Jungyu Seo, Kwan Soo Ko
doaj   +1 more source

Resistance to Colistin Mediated by mcr-1 among Multidrug Resistant Gram Negative Pathogens at a Tertiary Care Hospital, Egypt

, 2020
Colistin is considered the last option for treatment of infections caused by Multidrug Resistant (MDR) Gram negative pathogens. The mcr-1 gene could transfer the resistance to colistin between different species.
Noha Alaa Eldin Fahim, Nagwa M Abo El Magd, Nagwa M. Abo El Magd, Marwa Shabban, Karim Montasser   +4 more
core   +1 more source

Effects of an Organic Acid Blend on Growth Performance, Redox Homeostasis, and Intestinal Microbiota of Broilers in an Antibiotic‐Free Production System Under Winter Environmental Challenges

Animal Research and One Health, EarlyView.
Schematic summary of the effects of organic acids on growth performance and gut health‐related parameters in broilers. ABSTRACT This study was conducted to evaluate the effects of an organic acid blend on growth performance, redox homeostasis, and intestinal microbiota of broilers raised in an antibiotic‐free system during the winter season in China ...
Rong‐Hui Huang, Hong‐Lin Li, Yu Zhang, Jie Wang, Shao‐Qing Wang, Xue‐Wu Li, Lane Pineda, Xiang‐Dong Kuang, Giseli Heim, Mahmoud Mohamed Khalil, Lv‐Hui Sun, Zhang‐Chao Deng   +11 more
wiley   +1 more source

Safety and Efficacy of Intravenous Colistin (Colistin Methanesulphonate) for Severe Multidrug-Resistant Gram-Negative Bacterial Infections

, 2011
Multidrug-resistant (MDR) bacterial infections are increasing in Taiwan hospitals, prompting the common use of colistin. In this study, the safety and efficacy of intravenous (i.v.) colistin was assessed.
盛望徽;王振泰;陳宜君;張上淳;, SHENG, WANG-HUEI;WANG, JANN-TAY;CHEN, YEE-CHUN;CHANG, SHAN-CHWEN   +1 more
core   +1 more source

Comprehensive insights into colistin and colistin resistance: updated regulations and policies on colistin usage and alternative strategies for mitigation and prevention of colistin resistance

Novel Research in Microbiology Journal
The increase in antimicrobial resistance (AMR) has a significant impact on healthcare, leading to longer hospital stays and higher economic costs. This is primarily caused by the over and inappropriate use of antibiotics. Microorganisms have developed various mechanisms to combat the effects of antibiotics, including modifying their genetic material to
Zine El abidine Bzazou El Ouazzani, Laila Reklaoui, Monsif El Madany, Houda Benaicha, Said Barrijal   +4 more
openaire   +2 more sources

Involvement of hpap2 and dgkA Genes in Colistin Resistance Mediated by mcr Determinants

, 2020
Plasmid-mediated colistin resistance (mcr) determinants are challenging the efficacy of polymyxins against Gram-negative pathogens. Among 10 mcr genes described so far, the major determinants mcr-1 and mcr-3 are found closely linked to hpap2 or dgkA ...
Alberto Quesada, María Ugarte-Ruiz, Marta Hernández, Pedro Miguela-Villoldo, Lucas Domínguez, David Rodríguez-Lázaro, Alejandro Gallardo   +6 more
core   +1 more source

MgrB variants in colistin-susceptible and colistin-resistant Klebsiella pneumoniae ST258

Journal of Microbiology, Immunology and Infection, 2017
Resistance determinants of a colistin susceptible and five colistin resistant Klebsiella pneumoniae ST258 from a Hungarian outbreak were investigated. A novel MgrB variant in colistin susceptible strain was found. Elevated phoP and arn gene expressions and wild-type PmrB in all colistin resistant K. pneumoniae were detected. All strains lacked mcr-1.
Kocsis, Béla, Kádár, Béla, Tóth, Ákos, Fullár, Alexandra, Szabó, Dóra   +4 more
openaire   +4 more sources

Performances of the rapid polymyxin Acinetobacter and Pseudomonas tests for colistin susceptibility testing [PDF]

, 2019
Owing to the emergence of colistin resistance in nonfermenting Gram negative bacteria, reliable and rapid techniques for testing colistin susceptibility are needed.
Lescat, Mathilde, Poirel, L., Nordmann, P., Lescat, M., Jayol, A., Jayol, Aurélie, Nordmann, Patrice, Poirel, Laurent   +7 more
core   +1 more source

Colistin-stimulated ROS production is significantly impaired by the presence of colistin resistance-conferring proteins (EptA/MCR-1/ICR-Mo).

, 2018
A & B Accumulation of hydrogen peroxide is boosted by colistin stress in E. coli. C & D The presence of plasmid-borne EptA inhibits colistin-induced production of hydrogen peroxide in E. coli.
Swaminath Srinivas (450675), Jingxia Lin (3365054), Youjun Feng (16133), Vishnu Goutham Kota (5216144), Wenhui Wei (176525), Zichen Tang (3602876), Shihua Wang (219946), Saif Ullah (2360377)   +7 more
core   +1 more source