Results 51 to 60 of about 2,218,812 (219)

Evaluation of Plasmid Mediated Colistin Resistance in Colistin Resistant Gram-negative Bacilli

Journal of Kermanshah University of Medical Sciences, 2023
Background: Infections caused by carbapenem-resistant gram-negative bacteria are treated with colonistin as a last resort. However, the increased resistance in recent years is significant for treating multiple drug-resistant infections. Objectives: This study aimed to determine the resistance genes mobile colistin resistance (mcr)-1 and mcr-2 in the ...
Yeliz Tanriverdi Cayci, Kubra Hacieminoglu Ulker, Demet Gur Vural, Kemal Bilgin, Asuman Birinci   +4 more
openaire   +1 more source

Colistin: A mainstay antibiotic for treatment of fatal Gram negative bacterial infections [PDF]

ERU Research Journal
Our world is facing an enormous disaster due to spreading of the life-threatening bacterial infections, especially after the spread of multidrug-resistant Gram-negative bacteria (MDR-GNB), including those resistant to known antibiotics such as ...
Ahmed El-Khatib, Ahmed Basyony
doaj   +1 more source

Emergence of colistin resistance in the largest university hospital complex of São Paulo, Brazil, over five years

Brazilian Journal of Infectious Diseases, 2017
Colistin resistance involving Gram-negative bacilli infections is a challenge for health institutions around of the world. Carbapenem-resistance among these isolates makes colistin the last therapeutic option for this treatment. Colistin resistance among
Flávia Rossi, Raquel Girardello, Ana Paula Cury, Thais Sabato Romano Di Gioia, João Nóbrega de Almeida, Jr, Alberto José da Silva Duarte   +5 more
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Colistin Resistance Mechanisms in Human and Veterinary Klebsiella pneumoniae Isolates

, 2022
Colistin (polymyxin E) is increasingly used as a last-resort antibiotic for the treatment of severe infections with multidrug-resistant Gram-negative bacteria.
Lisa Sedlaczek, Paul G. Higgins, Stephan Göttig, Higgins, Paul G., Manuela Tietgen, Christa Ewers, Kaspar, Heike, Ewers, Christa, Göttig, Stephan, Sedlaczek, Lisa, Heike Kaspar, Tietgen, Manuela   +11 more
core   +1 more source

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Angewandte Chemie, EarlyView.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll, Pia Lanvers, Giulia Ravagnan, Kilian Klaus, Olena Nosovska, Ivan Vilotijevic, Jochen Schmid, Hajo Kries   +7 more
wiley   +2 more sources

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing

Scientific Reports, 2023
Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance.
Sjors P. A. van der Lans, Manon Janet-Maitre, Frerich M. Masson, Kimberly A. Walker, Dennis J. Doorduijn, Axel B. Janssen, Willem van Schaik, Ina Attrée, Suzan H. M. Rooijakkers, Bart W. Bardoel   +9 more
doaj   +1 more source

Isolation of colistin-resistant Hafnia alvei [PDF]

Journal of Medical Microbiology, 2009
n ...
Savini V, Catavitello C, Talia M, Balbinot A, Febbo F, POMPILIO, ARIANNA, DI BONAVENTURA, GIOVANNI, PICCOLOMINI, Raffaele, D'Antonio D.   +8 more
openaire   +4 more sources

Detection of Plasmid-Mediated Resistance against Colistin in Multi-Drug-Resistant Gram-Negative Bacilli Isolated from a Tertiary Hospital

, 2023
The aim of this study was to determine the prevalence of plasmid-mediated colistin resistance mcr-1 to mcr-5 genes among colistin and multi-drug-resistant Gram-negative bacilli strains isolated from patients in a tertiary hospital in Toluca, Mexico.
Laura Guadarrama-Monroy, José David Santiago-Luna, Reinaldo Pacheco-Vásquez, Humberto Navarrete-Salazar, Isabel Baltazar-Jiménez, Mario Galindo-Méndez, Devanhí Quintas-de la Paz   +6 more
core   +1 more source

Risk Factors for the Development of Colistin Resistance during Colistin Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections

Microbiology Spectrum, 2022
Colistin is one of the last-resort options for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections if novel antibiotics are unavailable, where the development of colistin resistance during treatment represents a major challenge for clinicians ...
Po-Han Huang, Wen-Yin Chen, Sheng-Hua Chou, Fu-Der Wang, Yi-Tsung Lin   +4 more
doaj   +1 more source