Results 51 to 60 of about 2,359,106 (231)

Combinations of colistin and bacteriocins prevent the selection of colistin resistance in Acinetobacter baumannii. [PDF]

Commun Biol
Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen responsible for infections that are often difficult to treat. Here, we show that exposure of A. baumannii to the last-resort antibiotic colistin, which disrupts the outer membrane of Gram-negative bacteria, results in inner membrane permeabilization and depolarization, ultimately ...
Rubio T, Zur Nedden T, Zedek S, Raoux-Bardot D, Cottineau C, Belot L, Raynaud C, Oms T, Rodriguez-Vilallobos H, Jurenas D, Chenal A, Van Melderen L.   +11 more
europepmc   +3 more sources

Acquisition of Colistin Resistance Links Cell Membrane Thickness Alteration with a Point Mutation in the lpxD Gene in Acinetobacter baumannii

, 2020
Acinetobacter baumannii is one of the most common causes of nosocomial infections in intensive care units. Its ability to acquire diverse mechanisms of resistance limits the therapeutic choices for its treatment.
Marwa S. Hesham, Reham Samir Mohamed, Neveen M. Saleh, Magdy A. Amin   +3 more
core   +1 more source

Isolation of colistin-resistant Hafnia alvei [PDF]

Journal of Medical Microbiology, 2009
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Savini V, Catavitello C, Talia M, Balbinot A, Febbo F, POMPILIO, ARIANNA, DI BONAVENTURA, GIOVANNI, PICCOLOMINI, Raffaele, D'Antonio D.   +8 more
openaire   +4 more sources

Association of Carbapenem and Colistin Resistance in Pathogenic Gram Negative Bacteria

, 2019
Diseases caused by multidrug-resistant (MDR) bacteria continue to challenge physicians and endanger their patients’ lives. Polymyxins, including colistin, are the last resort antibiotics to treat serious infections caused by carbapenem-resistant ...
Walid Bakeer, Sanaa Fadel, Magdi Amin, Reham Osama   +3 more
core   +1 more source

Colistin-resistance gene mcr in clinical carbapenem-resistant Enterobacteriaceae strains in China, 2014–2019

, 2020
To investigate whether introduction of colistin into the clinical settings selected colistin-resistant CRE, we performed molecular epidemiological study of 1868 CRE strains collected from different geographical locales in China during the period 2014 ...
Rong Zhang (44942), Edward Wai-Chi Chan (4356652), Qiaoling Sun (738882), Jiayue Lu (8376588), Sheng Chen (21971), Ning Dong (340660), Hong Huang (119275), Lingbin Shu (8376585)   +7 more
core   +1 more source

Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing

Scientific Reports, 2023
Due to multi-drug resistance, physicians increasingly use the last-resort antibiotic colistin to treat infections with the Gram-negative bacterium Klebsiella pneumoniae. Unfortunately, K. pneumoniae can also develop colistin resistance.
Sjors P. A. van der Lans, Manon Janet-Maitre, Frerich M. Masson, Kimberly A. Walker, Dennis J. Doorduijn, Axel B. Janssen, Willem van Schaik, Ina Attrée, Suzan H. M. Rooijakkers, Bart W. Bardoel   +9 more
doaj   +1 more source

Risk Factors for the Development of Colistin Resistance during Colistin Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections

Microbiology Spectrum, 2022
Colistin is one of the last-resort options for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections if novel antibiotics are unavailable, where the development of colistin resistance during treatment represents a major challenge for clinicians ...
Po-Han Huang, Wen-Yin Chen, Sheng-Hua Chou, Fu-Der Wang, Yi-Tsung Lin   +4 more
doaj   +1 more source

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Acquired Resistance to Colistin via Chromosomal And Plasmid-Mediated Mechanisms in Klebsiella pneumoniae

Infectious Microbes & Diseases, 2019
. The increasing prevalence of resistance to the last-resort antibiotics carbapenems is leading to increasing difficulties in treating infections caused by multidrug-resistant carbapenem-resistant Gram-negative bacteria such as Klebsiella pneumoniae. The
Björn Berglund, Stijn van der Veen
doaj   +1 more source

Colistin Resistance in Gram-Negative Bacteria: Mechanisms, Transmission, and Novel Intervention Strategies. [PDF]

Microorganisms
Multidrug resistance (MDR) in Gram-negative bacteria is a global issue and needs to be addressed urgently. MDR can emerge through genetic mutations and horizontal gene transfer and deteriorate under antibiotic selective pressure.
Zeb S, Nazir A, Hameed MF, Ikram S, Haider Naqvi SZ, Shoaib M, Butaye P, Wang Z, Li R, Lu X.   +9 more
europepmc   +2 more sources