Results 51 to 60 of about 32,247 (189)

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source

Heterogeneous Colistin-Resistance Phenotypes Coexisting in Stenotrophomonas maltophilia Isolates Influence Colistin Susceptibility Testing

Frontiers in Microbiology, 2018
The polymyxin antibiotic colistin shows in vitro activity against Stenotrophomonas maltophilia. However, an increased incidence of colistin-resistant isolates has been recently observed.
Sònia Martínez-Servat, Sònia Martínez-Servat, Daniel Yero, Daniel Yero, Pol Huedo, Pol Huedo, Roser Marquez, Gara Molina, Xavier Daura, Xavier Daura, Isidre Gibert, Isidre Gibert   +11 more
doaj   +1 more source

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Development of colistin resistance via heteroresistance modeling in : A diagnostic study [PDF]

Precision and Future Medicine
Purpose Colistin heteroresistance mediates the failure of antibiotic treatments, is prone to lead to colistin resistance, and has been frequently reported in Klebsiella pneumoniae.
Jungyu Seo, Kwan Soo Ko
doaj   +1 more source

Evaluation of a Product Intended for Microbiological Control in Animal Production, and Its Combination With Halquinol

Animal Research and One Health, EarlyView.
Activo Liquid and Halquinol inhibit Salmonella and Escherichia coli in culture media. Activo Liquid exhibits bactericidal action, whereas HA is bacteriostatic, and their combination results in positive or indifferent interactions. This combination effectively inhibits E. coli throughout digestion simulation, thus reducing the required concentrations of
Alberto Gonçalves Evangelista, Lucas dos Santos Janotto, Adriana Paula Possamai, Carolina Cini Perry, Francine Lemes Ribeiro, Rafael Canonenco de Araujo, Fernando Bittencourt Luciano   +6 more
wiley   +1 more source

Prevalence of the colistin resistance gene MCR-1 in colistin-resistant Klebsiella pneumoniae in Egypt

AIMS microbiology, 2023
Klebsiella pneumoniae is a nosocomial pathogen with high morbidity and mortality rates in hospitalized patients. The emergence of multidrug-resistant K. pneumoniae has become more challenging to treat, with the prevalence of colistin-resistance. Therefore, reliable methods for detecting colistin resistance are required. Many plants' essential oils have
Rania Abozahra, Amal A. Gab-Allah, Sarah M. Abdelhamid   +2 more
openaire   +3 more sources

The History of Colistin Resistance Mechanisms in Bacteria: Progress and Challenges

Microorganisms, 2021
Since 2015, the discovery of colistin resistance genes has been limited to the characterization of new mobile colistin resistance (mcr) gene variants. However, given the complexity of the mechanisms involved, there are many colistin-resistant bacterial ...
Mouna Hamel, Jean-Marc Rolain, Sophie Alexandra Baron   +2 more
doaj   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Expression of transcriptional regulator mgrB is enhanced in colistin-resistant Klebsiella pneumoniae: A report from India

Journal of Microbiology and Infectious Diseases
Background: Colistin is regarded as the final option for treating Gram-negative bacteria that are resistant to several drugs. A common resistance mechanism for colistin in Klebsiella pneumoniae is mgrB gene inactivation.
Rajkumari Elizabeth, Nikita Karmakar, Jayalaxmi Wangkheimayum, Bhaskar Jyoti Das, Dr.Debadatta Dhar (Chanda), Dr. Amitabha Bhattacharjee   +5 more
doaj   +1 more source

A Multifunctional Bioactive Nanoscale Coating Deposited by Atmospheric Pressure Plasma Polymerization of Peppermint Essential Oil

Small, EarlyView.
Atmospheric plasma polymerization transforms peppermint essential oil into ultrathin, substrate‐independent bioactive coatings with antioxidant, contact‐active antibacterial, and immunomodulatory functions. The coating disrupts Gram‐negative pathogens, potentiates prophylactic antibiotics, suppresses pro‐inflammatory signaling, and promotes M2 ...
Trong Quan Luu, Xuan Duy Do, Tuyet Pham, Ngoc Huu Nguyen, Richard Bright, Wenshao Li, Xiangyang Guo, Vi Khanh Truong, Andrew Hayles, Krasimir Vasilev   +9 more
wiley   +1 more source