Results 11 to 20 of about 1,026 (135)

CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway [PDF]

Cancer Medicine
Background Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein involved in tissue remodeling and fibrotic processes, which also suggests emerging roles in cancer.
Hang Yin, Yue Pan, Zhuang Li, Yong Liu, Jiatong Chen, Xin Chen, Chengfei Zhang, Feng Zhu, Chunzhao Yu   +8 more
doaj   +3 more sources

Overexpression of collagen triple helix repeat containing 1 (CTHRC1) is associated with tumour aggressiveness and poor prognosis in human non-small cell lung cancer. [PDF]

Oncotarget, 2014
Collagen triple helix repeat-containing 1 (CTHRC1), a novel oncogene, was identified to be aberrantly overexpressed in several malignant tumors. However, the expression profile of CTHRC1 and its clinical significance in non-small cell lung cancer (NSCLC) remain unknown.
Ke Z, He W, Lai Y, Guo X, Chen S, Li S, Wang Y, Wang L.   +7 more
europepmc   +4 more sources

Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders [PDF]

Frontiers in Aging Neuroscience
BackgroundCognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. We identified CTHRC1 (Collagen Triple Helix Repeat Containing 1) as a novel candidate associated with cognitive
Jie Xu, Jie Xu, Yuan He, Zhao Li, Wenrong Zhou, Chunjian Huang, Lu Lu, Akhilesh K. Bajpai, Min Li   +8 more
doaj   +2 more sources

CTHRC1 is associated with BRAF(V600E) mutation and correlates with prognosis, immune cell infiltration, and drug resistance in colon cancer, thyroid cancer, and melanoma [PDF]

Biomolecules & Biomedicine
Colon cancer, thyroid cancer, and melanoma are common malignant tumors that seriously threaten human health globally. The B-Raf proto-oncogene, serine/threonine kinase (BRAF)(V600E) mutation is an important driver gene mutation in these cancer types. In
Rumeng Zhang, Zhihao Wang, Huan Wang, Lin Li, Lin Dong, Lin Ding, Qiushuang Li, Linyan Zhu, Tiantian Zhang, Yong Zhu, Keshuo Ding   +10 more
doaj   +2 more sources

CTHRC1/TGF-β/Smad axis serves as therapeutic targets in inhibiting oral squamous cell carcinoma by mediating ferroptosis [PDF]

Discover Oncology
Background Collagen triple helix repeat containing 1 (CTHRC1) is an oncogene in numerous human cancers including oral squamous cell carcinoma (OSCC). However, whether and how CTHRC1 influences OSCC progression through ferroptosis has not been completely ...
Shihao Huang, Yiming Jiao, Yongchun Chang, Yu Feng, Guixian Mu, Linli Xie   +5 more
doaj   +2 more sources

Collagen triple helix repeat containing 1 (Cthrc1) is an independently prognostic biomarker of non-small cell lung cancers with cigarette smoke

Tumor Biology, 2014
Collagen triple helix repeat containing 1 (Cthrc1) has been recently documented in various malignancies, but its role in non-small cell lung cancer (NSCLC) remains uncertain. In the current study, we investigated the level of Cthrc1 in NSCLC tissues by immunohistochemistry.
Xiaojun, Liu, Beiyan, Liu, Ying, Cui, Fengping, Wang, Hui, Sun, Fuzhen, Lv   +5 more
exaly   +3 more sources

CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway

Advanced Science
Tendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is
Cheng Chen, Xu Zheng, Cheng Wang, HaiChao Zhou, Yi Zhang, TianBao Ye, YunFeng Yang   +6 more
doaj   +2 more sources

Assessment of Plasma Level of CTHRC-I in Patients with Rheumatoid Arthritis

The Iraqi Journal of Medical Sciences, 2021
Background: Rheumatoid arthritis (RA) is a chronic progressive, autoimmune disease that affects about 1.5% of the community. New markers are needed for early diagnosis of RA as seronegativity in early RA remains a major limitation of both anti ...
Sahar Alwan, Raja Abdul-Ridha, Alaa Ali
doaj   +9 more sources

CTHRC1: a key player in colorectal cancer progression and immune evasion [PDF]

Frontiers in Immunology
The multifunctional secreted protein, collagen triple helix repeat containing 1 (CTHRC1), has recently emerged as a significant focus within oncology research.
Qingjie Chen, Haohao Wang, Qinghua Liu, Changjiang Luo   +3 more
doaj   +2 more sources

Expression, Prognostic Value, and Biological Function of CTHRC1 in Different Types of Gliomas: A Bioinformatic Analysis and Experiment Validation [PDF]

Clinical Medicine Insights: Oncology
Background: In recent years, abnormal expression of collagen triple helix repeat containing 1 (CTHRC1) has been found in some tumors, closely related to the poor prognosis of cancer patients. However, the clinical significance of CTHRC1 in gliomas is not
Xueping Shi, Xi Zeng, Rukai Jiao, Yushi Yang, Xiaolin Du, Jiacai Qian, Jian Liu, Guangtang Chen   +7 more
doaj   +2 more sources