CTHRC1 promotes anaplastic thyroid cancer progression by upregulating the proliferation, migration, and invasion of tumor cells [PDF]
PeerJ, 2023 Anaplastic thyroid carcinoma (ATC) is an extremely aggressive tumor with a high mortality rate and poor prognosis. However, the pathogenesis of ATC is complex and poorly understood, and the effective treatment options are limited.
Yong Chen +5 more
doaj +2 more sources
Effects of CTHRC1 on odontogenic differentiation and angiogenesis in human dental pulp stem cells [PDF]
Restorative Dentistry & Endodontics, 2023 ObjectivesThis study aimed to determine whether collagen triple helix repeat containing-1 (CTHRC1), which is involved in vascular remodeling and bone formation, can stimulate odontogenic differentiation and angiogenesis when administered to human dental ...
Jong-soon Kim +5 more
doaj +1 more source
The Role of Collagen Triple Helix Repeat-Containing 1 Protein (CTHRC1) in Rheumatoid Arthritis [PDF]
International Journal of Molecular Sciences, 2020 Rheumatoid arthritis (RA) is a chronic autoimmune disease, causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as a biomarker
Askhat Myngbay +3 more
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Frontiers in Genetics, 2022 Background: Gastric cancer (GC) is a common cancer with high mortality. This study aimed to identify its differentially expressed genes (DEGs) using bioinformatics methods.Methods: DEGs were screened from four GEO (Gene Expression Omnibus) gene ...
Chenyu Sun +16 more
doaj +1 more source
CTHRC1 (Collagen Triple Helix Repeat Containing 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on CTHRC1 (Collagen Triple Helix Repeat Containing 1), with data on DNA, on the protein encoded, and where the gene is implicated.
LeClair, R, Durmus, T, Lindner, V
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Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma
Frontiers in Molecular Biosciences, 2022 Colon adenocarcinoma (COAD), ranking third in incidence and second in mortality, is one of the most common cancer types in the world. The initial stages of COAD usually show no obvious clinical symptoms; moreover, effective screening or diagnostic ...
Chen Pang +3 more
doaj +1 more source
Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis. [PDF]
PLoS ONE, 2013 Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found that the CTHRC1 gene is overexpressed in hepatocellular carcinoma (HCC ...
Yu-Ling Chen +4 more
doaj +1 more source
Role of Scar-Associated Macrophages in Organ Fibrosis Diseases. [PDF]
J Immunol ResFibrosis refers to the scarring and hardening of tissue resulting from the excessive deposition of extracellular matrix (ECM) proteins by myofibroblasts during chronic inflammatory responses, which can ultimately lead to organ failure and potentially death.
Ding R +6 more
europepmc +2 more sources
The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets
Frontiers in Genetics, 2022 Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. However, its specific role and mechanism with immune infiltrates in gastric cancer are still unclear ...
Lulu Zhao +5 more
doaj +1 more source