Results 41 to 50 of about 1,026 (135)

CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9

BMC Cancer, 2018
Background The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion.
Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke   +18 more
doaj   +1 more source

Cthrc1, a novel circulating hormone regulating metabolism. [PDF]

PLoS ONE, 2012
We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not
J Patrizia Stohn, Nicole G Perreault, Qiaozeng Wang, Lucy Liaw, Volkhard Lindner   +4 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Assessing Aβ‐independent effects of Module 42 on immune function in vitro

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION A deep multi‐omic analysis of post mortem human brains has identified a new co‐expression protein network – Module 42 (M42), strongly corelated with Alzheimer's disease (AD) pathology. M42 comprises 32 transmembrane and extracellular matrix (ECM)‐associated proteins, including the amyloid precursor protein (APP) and apolipoprotein
Ishita Ajith, Souvika Bakshi, Emma Mead, Opher Gileadi, Vittorio L. Katis, Paul E. Brennan, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Katerina O. Gospodinova   +7 more
wiley   +1 more source

Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances

Exploration, Volume 6, Issue 1, February 2026.
This review elaborates on current research on immune modulation in tissue regeneration, emphasizing the roles of proinflammatory and anti‐inflammatory cells. This review also explored the potential of biomaterials for modulating the wound environment to promote scarless healing.
Yong Kang, Yiwen Yang, Bin Yao, Zhuhong Zhang, Xiaoyuan Ji   +4 more
wiley   +1 more source

Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

Cancer Cell International, 2021
Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1
Dazhao Peng, Cheng Wei, Xiaoyang Zhang, Shenghui Li, Hao Liang, Xingyu Zheng, Shulong Jiang, Lei Han   +7 more
doaj   +1 more source

Sex differences in the physiological response to acute anterior cruciate ligament overuse

The Journal of Physiology, Volume 604, Issue 1, Page 297-316, 1 January 2026.
Abstract figure legend With equivalent in vivo fatigue loading of the anterior cruciate ligament (ACL), females accumulate more tissue damage and mount a slower reparative response than males, when the applied loads between sexes are equivalent. By contrast, males accumulate less tissue damage and mount a robust reparative response that includes ...
Stephen H. Schlecht, Benjamin E. Loflin, Adam R. Carter, Roufael Hanna, Simran Shergill, Edward M. Wojtys   +5 more
wiley   +1 more source

CTHRC1 facilitates bladder cancer cell proliferation and invasion through regulating the PI3K/Akt signaling pathway

Archives of Medical Science, 2019
Introduction Emerging evidence has illustrated that Collagen triple helix repeat containing 1 (CTHRC1) is crucial for tumorigenesis and development. However, the effects of CTHRC1 on bladder cancer progression remain largely unclear.
Yubing Li, Xiangdong Cheng, Jiasheng Yan, Shaobo Jiang   +3 more
doaj   +1 more source

CTHRC1 promotes bone metastasis in prostate cancer

International Journal of Cancer, Volume 157, Issue 11, Page 2399-2412, 1 December 2025.
What's New? The mechanisms driving bone metastasis in prostate cancer are still unclear, and predicting markers have not yet been identified. Based on the biological characterization of prostate cancer cell lines and integrated data analysis of clinical samples, the authors identified CTHRC1 as a candidate gene regulating prostate cancer bone ...
Yuichiro Sawada, Tadahiko Kikugawa, Tomoya Onishi, Osuke Arai, Hiroyuki Iio, Noriyoshi Miura, Shuhei Yoshida, Aoi Ikedo, Yuta Yanagihara, Noritaka Saeki, Iori Sakakibara, Balázs Győrffy, Takeshi Kishida, Yoichiro Okubo, Yoshiyasu Nakamura, Shinya Sato, Yohei Miyagi, Takashi Saika, Yuuki Imai   +18 more
wiley   +1 more source

The collagen triple helix repeat-containing 1 (CTHRC1) is transcriptionally modulated in the spinal cords of salamanders following traumatic resection.

, 2020
In nature, there are extraordinary creatures that have the ability to regenerate spinal cord tissue following traumatic injuries (1, 2, 3, 4). We mined published microarray data (5, 6) to understand in an unbiased fashion how this process transpires, by studying transcription at the systems level in the spinal cord tissue of axolotl salamanders ...
openaire   +2 more sources