Results 51 to 60 of about 1,026 (135)

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu, Wuyuan Liao, Youyan Tan, Hansen Lin, Kun Ye, Xinwei Zhou, Mingjie Lin, Kangbo Huang, Minyu Chen, Jietao Wei, Haoqian Feng, Yuhang Chen, Jinwei Chen, Bohong Guan, Shan Li, Zhengkun Zhang, Anze Yu, Zihao Feng, Lizhen Zhang, Guannan Shu, Jun Lu, Wei Chen, Yihui Pan, Jiefeng Yang, Junhang Luo, Li Luo   +25 more
wiley   +1 more source

Recent Advances in Deciphering Normal and Diseased Aortic Valve Biology Using Transcriptomic Technologies

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Calcific aortic valve disease (CAVD) is a growing global health burden, with no approved pharmacological treatments to date, indicating a substantial therapeutic gap and the need for deeper insight into its underlying mechanisms. Transcriptomic approaches, particularly RNA sequencing (RNAseq) and single‐cell sequencing (scRNAseq), are emerging
Monica Madalina Tucureanu, Ileana Manduteanu   +1 more
wiley   +1 more source

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 8, August 2025.
Targeting ECM dysregulation: therapeutic strategies for disease intervention. Dysregulated ECM composition and biomechanics contribute to disease pathogenesis in cancer and fibrotic disorders. Physical modulation: Nanomedicine‐based strategies tune ECM physical properties (e.g., density, stiffness) to enhance drug penetration and therapeutic efficacy ...
Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

CTHRC1 Acts as a Prognostic Factor and Promotes Invasiveness of Gastrointestinal Stromal Tumors by Activating Wnt/PCP-Rho Signaling

Neoplasia: An International Journal for Oncology Research, 2014
Gastrointestinal stromal tumors (GISTs) are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To
Ming-Ze Ma, Chun Zhuang, Xiao-Mei Yang, Zi-Zhen Zhang, Hong Ma, Wen-Ming Zhang, Haiyan You, Wenxin Qin, Jianren Gu, Shengli Yang, Hui Cao, Zhi-Gang Zhang   +11 more
doaj   +1 more source

Unraveling Alveolar Fibroblast and Activated Myofibroblast Heterogeneity and Differentiation Trajectories During Lung Fibrosis Development and Resolution in Young and Old Mice

Aging Cell, Volume 24, Issue 5, May 2025.
Model of LIF‐to‐aMYF reversible switch during fibrosis formation and resolution in old mice. The main contributors during fibrosis formation to Cthrc1+ aMYF are Acta2+ LIFhigh alveolar fibroblasts. During fibrosis resolution, Cthrc1+ aMYF differentiate back to the LIFhigh (please write "high" in superscript) alveolar fibroblasts cluster.
Arun Lingampally, Marin Truchi, Xianrong Shi, Yuqing Zhou, Esmeralda Vasquez‐Pacheco, Georgios‐Dimitrios Panagiotidis, Stefan Hadzic, Janine Koepke, Ana Ivonne Vazquez‐Armendariz, Susanne Herold, Christos Samakovlis, Hector A. Cabrera‐Fuentes, Xuran Chu, Werner Seeger, Jin‐San Zhang, Elie El Agha, Bernard Mari, Saverio Bellusci, Chengshui Chen   +18 more
wiley   +1 more source

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Advanced Therapeutics, Volume 8, Issue 1, January 2025.
Among bone biomaterial strategies, many have investigated the use of different material cues to direct osteoblasts. However, less attention is given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling ...
Kaavian Shariati, Meiwand Bedar, Kelly X. Huang, Shahrzad Moghadam, Sarah Mirzaie, Jonnby S. LaGuardia, Wei Chen, Youngnam Kang, Xiaoyan Ren, Justine C. Lee   +9 more
wiley   +1 more source

3D Printing‐Based Hydrogel Dressings for Wound Healing

Advanced Science, Volume 11, Issue 47, December 18, 2024.
This review comprehensively describes the development of customizable multi‐functional 3D printing‐based hydrogel dressings in the field of wound healing, objectively evaluates the advantages and disadvantages from various perspectives, and proposes the core development concept, which is obviously distinct from previous work and will provide valuable ...
Xuan Zhou, Xunzhou Yu, Tingting You, Baohua Zhao, Lanlan Dong, Can Huang, Xiaoqing Zhou, Malcolm Xing, Wei Qian, Gaoxing Luo   +9 more
wiley   +1 more source

Analysis of the senescence‐associated cell surfaceome reveals potential senotherapeutic targets

Aging Cell, Volume 23, Issue 12, December 2024.
We employed label‐free quantitative mass spectrometry to comprehensively investigate the cell surface proteome across eight distinct senescence models. Our findings highlighted extensive modifications in cell mechanics and extracellular matrix remodeling during senescence.
Yushuang Deng, Ting Liu, Enzo Scifo, Tao Li, Kan Xie, Bernd Taschler, Sarah Morsy, Kristina Schaaf, Armin Ehninger, Daniele Bano, Dan Ehninger   +10 more
wiley   +1 more source

Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application

Clinical and Translational Medicine, Volume 14, Issue 11, November 2024.
A comprehensive summary of various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in diagnosis and treatment. The role of DNA methylation in regulating hepatocellular carcinoma's (HCC) malignant progression and sorafenib resistance, alongside elaborating therapeutic effects of DNA methyltransferase inhibitors.
Lin Su, Jiawen Bu, Jiahui Yu, Mila Jin, Guanliang Meng, Xudong Zhu   +5 more
wiley   +1 more source

From Cell to Gene: Deciphering the Mechanism of Heart Failure With Single‐Cell Sequencing

Advanced Science, Volume 11, Issue 39, October 23, 2024.
This review summarizes the current applications of single‐cell sequencing (SCS) in elucidating the mechanisms of heart failure (HF), including energy metabolism, inflammation, ischemia, extracellular matrix remodeling, and small molecular mediators. It emphasizes cardiomyocyte heterogeneity and intercellular communication, providing insights into gene ...
Dan Zhang, Qiang Wen, Rui Zhang, Kun Kou, Miao Lin, Shiyu Zhang, Jun Yang, Hangchuan Shi, Yan Yang, Xiaoqiu Tan, Shigang Yin, Xianhong Ou   +11 more
wiley   +1 more source