Results 101 to 110 of about 1,359,174 (352)

A cartilage tissue engineering approach combining starch-polycaprolactone fibre mesh scaffolds with bovine articular chondrocytes [PDF]

, 2007
In the present work we originally tested the suitability of corn starch-polycaprolactone (SPCL) scaffolds for pursuing a cartilage tissue engineering approach. Bovine articular chondrocytes were seeded on SPCL scaffolds under dynamic conditions using
A. Crawford, A. CRAWFORD, A. J. GRODZINSKY, A. J. SALGADO, A. J. SALGADO, A. J. SALGADO, A. P. MARQUES, A. P. MARQUES, A. R. Moreira, A. W. T. SHUM, B. DOZIN, C. KAPS, C. R. LEE, D. W. HUTMACHER, E. M. DARLING, F. P. LUYTEN, G. CHEN, J. J. A. BARRY, J. LI, J. M. Mundy, J. S. TEMENOFF, J. T. Oliveira, J.-A. HAN, K. A. ATHANASIOU, K. R. BRODKIN, K. UEMATSU, M. B. YAYLAOGLU, M. E. Gomes, M. E. GOMES, M. E. GOMES, M. E. GOMES, P. CUEVAS, P. GIANNONI, P. V. Hatton, R. CANCEDDA, R. CANCEDDA, R. L. Reis, R. S. TARE, S. LOTY, T. FUNAMI, V. J. D. CIOLFI, W. J. LI, W. KAFIENAH, W. ZHU, W.-J. LI, Z. GUGALA, Z. GUGALA   +46 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Region specific microstructural complexity of the ovine meniscus root provides an organizational basis for injury susceptibility

Scientific Reports
Comprehensive information on the meniscus root microstructure is essential to exactly understand its physiological role and susceptibility to injury. We selected the ovine medial meniscus anterior root (MAR) as model to elucidate the intricate spatial ...
Marta Carretero-Hernández, Yin Zhang, Wei Liu, Magali Cucchiarini, Henning Madry   +4 more
doaj   +1 more source

Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes

Journal of Pharmacological Sciences, 2015
Salinomycin (SAL), a monocarboxylic polyether antibiotic isolated from Streptomyces albus, modulates various cellular responses, including proliferation, apoptosis, and inflammation.
Seon-Mi Yu, Song-Ja Kim
doaj   +1 more source

The skeletal phenotype of chondroadherin deficient mice [PDF]

, 2013
Chondroadherin, a leucine rich repeat extracellular matrix protein with functions in cell to matrix interactions, binds cells via their a2b1 integrin as well as via cell surface proteoglycans, providing for different sets of signals to the cell ...
A Franzen, A Vortkamp, B Ganss, B Lanske, B Mansson, C Landgren, C Wiberg, Christiane Petzold, Christina Wenglén, Dick Heinegård, E Hedbom, Elizabeth K. Tanner, ES Baekkevold, Espen S. Baekkevold, Finn P. Reinholt, FP Reinholt, GK Hunter, Gunhild A. Stordalen, H Kojima, HY Zhou, J Sodek, JA Gordon, JM Johnson, K Hultenby, K Hultenby, KG Danielson, L Camper, L Svensson, Lovisa Hessle, M Mizuno, Nikos K. Karamanos, P Bianco, Patrik Önnerfjord, PJ Neame, R Fassler, S Chakravarti, SH Brorson, Sverre-Henning Brorson, T Hildebrand, T Larsson, T Xu, WJ Whitehouse, Y Sommarin, Y Sommarin, Z Shen   +44 more
core   +4 more sources

Beta 1 integrins mediate chondrocyte interaction with type I collagen, type II collagen, and fibronectin.

Experimental Cell Research, 1993
Chondrocytes isolated from the cephalic region of sterna from 14-day-old chick embryos used beta 1 integrins and required either Mg2+ or Mn2+ for attachment to plates coated with type I collagen, type II collagen, and fibronectin.
Motomi I. Enomoto, Phoebe S. Leboy, A. Menko, David Boettiger   +3 more
semanticscholar   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

PPAR-δ Agonist With Mesenchymal Stem Cells Induces Type II Collagen-Producing Chondrocytes in Human Arthritic Synovial Fluid

Cell Transplantation, 2017
Osteoarthritis (OA) is an inflammatory joint disease characterized by degeneration of articular cartilage within synovial joints. An estimated 27 million Americans suffer from OA, and the population is expected to reach 67 million in the United States by
Bruce E. Heck, Joshua J. Park, Vishruti Makani, Eun-Cheol Kim, Dong Hyun Kim   +4 more
doaj   +1 more source

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami, Benderdour, Chu, Collins, Conti, Cooke, Fang, Feng, Goodridge, Goodridge, Goodridge, Gulen, Harnett, Harrington, Ito, Ivanov, Kelchtermans, Kenny, Koenders, Koshy, Kulkarni, Langrish, Lubberts, Marshall, Martin, McInnes, Murugaiyan, Nakae, Naor, Niedbala, Petermann, Pickens, Price, Reynolds, Roark, Sato, Shahrara, Shibata, Staschke, Sutton, Szanto, Takayanagi, Tanaka, Vermeire, Whelan, Xu, Xu, Yago   +47 more
core   +1 more source

Influence of alginate on type II collagen fibrillogenesis

Journal of Materials Science: Materials in Medicine, 2005
Collagen II is the majority of extracellular matrix components in articular cartilage, which with the major functions of preventing expansion of the tissue and distributing the load of body weight. To obtain man-made ECM, the reconstitution of collagen could be conducted in the presence of negatively charged polysaccharide, such as alginate.
Shyh Ming, Kuo, Yng Jiin, Wang, Chin Lung, Weng, Huai En, Lu, Shwu Jen, Chang   +4 more
openaire   +2 more sources