Results 131 to 140 of about 21,718 (291)
Advanced Science, EarlyView.We present the MyoRobot 3.0, an advanced platform that combines high‐resolution imaging with automated mechanical testing to improve the accuracy of single muscle fibre analysis. The system tracks fibre diameter changes during stretch, preventing major stress miscalculations.
Michael Haug +5 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan +6 more
wiley +1 more source
Can Type VII Collagen Injections Cure Dystrophic Epidermolysis Bullosa?
Molecular Therapy, 2009 Intensive international efforts are being made to devise new molecular therapies for genetic skin diseases.1 There are three major reasons for these efforts. First, the skin is the largest organ in the human body, with an area of almost 2 m2 and a weight of 2–3 kg. Therefore, diseases of the skin have a severe negative impact on the daily functions and
openaire +3 more sources
Colocalization of type VII collagen and GFAP within vesicle clusters and corpora amylacea.
, 2016 Image of the inner retina, paraffin section. Type VII collagen labeling (polyclonal; green) colocalizes with that of GFAP (monoclonal; red). The vesicle cluster around one nucleus (left white arrowhead) contains both Col-VII and GFAP-positive vesicles ...
Roelofje J. Van der Worp (5666341) +4 more
core +1 more source
Advanced Science, EarlyView.An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li +7 more
wiley +1 more source
, 2015 (a) LH3 immunoreactivity (red) does not change after bone marrow transplantation in two RDEB patients. (b) Type VII collagen expression (green) is increased after bone marrow transplantation. d = day, yr = year. Graph shows morphometric quantification of
Megan Riddle (797735) +15 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan +5 more
wiley +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Osteogenesis imperfecta - Clinical and molecular diversity
European Cells & Materials, 2003 Osteogenesis imperfecta is a heritable disorder of bone formation resulting in low bone mass and a propensity to fracture. It exhibits a broad range of clinical severity, ranging from multiple fracturing in utero and perinatal death to normal adult ...
Roughley P. J., Rauch F., Glorieux F. H.
doaj
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source