Results 131 to 140 of about 7,552,757 (294)

Type VII collagen is visualized within corpora amylacea (T8100).

, 2016
Immuno-electron microscopic image of the inner plexiform layer of a human retina. Immunogold-labeled polyclonal antibody directed against type VII collagen labels two corpora amylacea diffusely.
Roelofje J. Van der Worp (5666341), Leonoor I. Los (89478), Hendri H. Pas (89476), Bart Wullink (841699), Roel Kuijer (205680)   +4 more
core   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Novel eRF3a degrader enhances gentamicin-induced premature termination codon readthrough in epidermolysis bullosa

Molecular Therapy: Nucleic Acids
Recessive dystrophic epidermolysis bullosa (RDEB) and junctional epidermolysis bullosa (JEB) are severe blistering skin disorders caused by mutations in genes encoding type VII collagen (COL7A1) and laminin 332 (LAMA3, LAMB3, or LAMC2), respectively.
Kathleen L. Miao, Brandon Levian, Yingping Hou, Ryan Huynh, Kate Zheng, Mei Chen   +5 more
doaj   +1 more source

The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn\u27s disease have autoantibodies to type VII collagen

, 2002
peer-reviewedEpidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen.
WEIR, DONALD, KELLEHER, DERMOT P
core  

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Excellent response to rituximab in a patient with recalcitrant epidermolysis bullosa acquisita: a case report

Journal of the Egyptian Women’s Dermatologic Society
Epidermolysis Bullosa Acquisita is a rare, chronic autoimmune blistering disorder characterized by vesicles and bullae on the skin and mucous membranes.
Fahad Alrashidi, Khalid Nabil Nagshabandi, Ruaa Alharithy   +2 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Endogenous but not exogenous type VII collagen increases LH3 expression in RDEB keratinocytes.

, 2015
(a) Retroviral delivery of type VII collagen in RDEB14 keratinocytes increases LH3 expression by immunofluorescence. (b) Type VII collagen increases LH3 in RDEB14 keratinocytes in cell extracts and conditioned media by immunoblotting. (c) siRNA depletion
Megan Riddle (797735), John A. McGrath (797738), Irene M. Leigh (155355), Ulrike Gartner (426351), W. H. Irwin McLean (192472), Stephen A. Watt (797732), Celine Pourreyron (182170), James R. McMillan (797736), Marco Prisco (797737), Sheila Wright (797734), Emma Warbrick (426350), Jakub Tolar (298070), Jasbani H. S. Dayal (797733), Roy M. Kimble (695687), Julio C. Salas-Alanis (564965), Andrew P. South (182203)   +15 more
core   +1 more source

Adhesion‐Enhanced Engineered Probiotic for Prolonged Intestinal Retention and Calprotectin‐Responsive IBD Therapy

Advanced Science, EarlyView.
An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang, Peichao Zhang, Simin Gu, Hongyun Lu, Ningning Jiang, Jiarun Zhao, Enbo Xu, Xiayu Liu, Ying Shi, Qihe Chen   +9 more
wiley   +1 more source

Can Type VII Collagen Injections Cure Dystrophic Epidermolysis Bullosa?

Molecular Therapy, 2009
Intensive international efforts are being made to devise new molecular therapies for genetic skin diseases.1 There are three major reasons for these efforts. First, the skin is the largest organ in the human body, with an area of almost 2 m2 and a weight of 2–3 kg. Therefore, diseases of the skin have a severe negative impact on the daily functions and
openaire   +3 more sources