Results 161 to 170 of about 21,718 (291)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Identification of novel plasma proteomic biomarkers of Dupuytren disease. [PDF]

PLoS One
Hummer B, Sebastiani P, Leshchyk A, Gurinovich A, Bager C, Karsdal M, Nielsen S, Eaton C.   +7 more
europepmc   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

A block staining method using ethanolic phosphotungstic acid for the visualisation of collagens in transmission electron microscopy. [PDF]

PLoS One
Obermayer A, Hainzl S, Koller U, Lang D, Lamprecht B, Stoiber W.   +5 more
europepmc   +1 more source

A detailed redescription of a skeletally immature ‘Redondasaurus’ suggests ontogenetic transformations in the taxon mirror phytosaurian morphological evolution

The Anatomical Record, EarlyView.
Abstract The study of morphological evolution is fundamentally tied to ontogeny, yet studies of these heterochronic processes in the fossil record are rare. Fossils belonging to an ontogenetic series are difficult to assign to an ontogenetic stage due to inconsistent proxies for skeletal ages, challenging to taxonomically assign due to morphological ...
Erika R. Goldsmith, Michelle R. Stocker
wiley   +1 more source

Dilated Cardiomyopathy and Aortic Thrombosis in a Capuchin Monkey (Sapajus apella). [PDF]

J Med Primatol
Helm C, Bracke A, Teifke JP, Ulrich R.
europepmc   +1 more source

3D anatomical atlas of the heads of male and female adult Chamaeleo calyptratus

The Anatomical Record, EarlyView.
The veiled chameleon is a model organism in reptile development research. Utilizing contrast‐enhanced microCT and deep learning segmentation models, we have generated the first digital atlases of the skull, nervous system, cranial muscles and hyolingual muscles.
Alice Leavey, Eloy Gálvez‐López, Anthony Herrel, Laura B. Porro   +3 more
wiley   +1 more source

Systemic clinical-grade recombinant decorin reduces disease burden and fibrosis in advanced recessive dystrophic epidermolysis bullosa. [PDF]

Mol Ther Adv
Gretzmeier C, Hang B, Sengle G, Phillips C, Buer B, Fletcher S, Belov A, Bleck G, Collins IJ, Brinckmann J, de Souza MP, Landy H, Nyström A.   +12 more
europepmc   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source

Alporting Trouble Down the Tubules. [PDF]

Kidney Int Rep
Chan M, Gross O.
europepmc   +1 more source