Results 61 to 70 of about 197,604 (257)

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

Drug Delivery, 2018
Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies.
Anni Pan, Zhaoyang Wang, Binlong Chen, Wenbing Dai, Hua Zhang, Bing He, Xueqing Wang, Yiguang Wang, Qiang Zhang   +8 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Undervalued ubiquitous proteins

4 open, 2019
The role of ubiquitous proteins (UPs) and their corresponding enzymes have been underestimated in carcinogenesis as the focus of much research revolved around measuring mutations and/or other genetic epiphenomena as surrogate markers of cancer and cancer
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

COLLAGENASE IN SJOGRENS-SYNDROME

, 1994
KONTTINEN YT, KANGASPUNTA P, LINDY O, et al. COLLAGENASE IN SJOGRENS-SYNDROME. ANNALS OF THE RHEUMATIC DISEASES. 1994;53(12):836-839.Objective-To study collagenase production in labial salivary glands in patients with Sjogren's syndrome (SS).
Tschesche, Harald, LINDY, O, SEGERBERG, M, SORSA, T, KONTTINEN, YT, KANGASPUNTA, P, TAKAGI, M, EISEN, AZ   +7 more
core   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Insight into the spoilage heterogeneity of meat-borne bacteria isolates with high-producing collagenase

Food Science and Human Wellness
Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing, resulting in spoilage. Cutting parts of chilled chicken, especially wings, feet, and other skin-on products, are abundant in collagen, which may be the ...
Haodong Wang, Liangting Shao, Jinhao Zhang, Xinglian Xu, Jianjun Li, Huhu Wang   +5 more
doaj   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

BIOSYNTHESIS OF INDUSTRIAL ENZYMES BY FREE AND IMMOBILIZED Alicyclobacillus spp IN DIFFERENT MATRICES AND THE USE OF ULTRAFILTRATION IN THE ENZYMES CONCENTRATION

Química Nova
The biosynthesis of amylase and collagenase, produced by A. acidocaldarius and A. sendaiensis respectively, were studied, and different matrices evaluated for the microorganisms immobilization and enzymes production optimization, such as loofa sponge ...
Suelen Pereira Ruiz, Juliana Harumi Miyoshi, Gabriela Gregolin Gimenez, Camila Ortiz Martinez, Benício Alves de Abreu Filho, Graciette Matioli   +5 more
doaj   +1 more source

Collagenase expression by normal human eosinophils

, 1998
Collagenolytic activity was detected in extracts from human blood eosinophilic granulocytes. To characterize this collagenase, we compared extracts from isolated populations of eosinophils and neutrophils.
Karen A Hasty, Boris V Shlopov
core   +1 more source