Results 171 to 180 of about 7,134 (210)

Collectins and innate immunity in the lung

Microbes and Infection, 2000
Evidence from both in vitro and in vivo studies suggests that the collectins are important elements in host innate immune defences against infectious agents. Study of the collectins in specific disease settings now raises the prospects of developing therapies exploiting these mechanisms of innate immunity.
H W, Clark, K B, Reid, R B, Sim
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Collectins and Ficolins

Protein-carbohydrate interactions are utilized by the immune system for several defense activities. Collectins and ficolins have a key role in maintaining the balance of surfactants in the lungs and supporting the immune system in the lungs, respectively. This chapter provides an extensive description of two soluble pattern recognition receptors (PRRs),
Hajra, Gupta, Ann Mary, Joseph, Mughair, Abdul Aziz, Faryal, Saeed, Rekha, Kumari, Khaled, Masmoudi, Uday, Kishore, Taruna, Madan   +7 more
openaire   +2 more sources

Collectins and Pentraxins

2007
Innate immunity is the first line of defense against pathogens. It plays a key role in the activation and orientation of adaptive immunity. Recognition and elimination of pathogens and of dying cells is mediated by pattern recognition receptors (PPRs) that have both cellular and humoral components.
Uday Kishore, Kenneth B.M. Reid
openaire   +1 more source

Collectins and their role in lung immunity

Journal of Leukocyte Biology, 2003
AbstractThe collectins are a small family of secreted glycoproteins that contain C-type lectin domains and collagenous regions. They have an important function in innate immunity, recognizing and binding to microorganisms via sugar arrays on the microbial surface.
Hickling, T.P, Clark, Howard W., Malhotra, R., Sim, R.B.   +3 more
openaire   +3 more sources

Structures and Functions of Mammalian Collectins

2001
Protein-carbohydrate interactions serve multiple functions in the immune system. Many animal lectins (sugar binding proteins) mediate both pathogen recognition and cell-pathogen interactions using structurally related calcium-dependent carbohydrate recognition domains (C-type CRDs).
U, Kishore, K B, Reid
openaire   +2 more sources

Collectins and pulmonary innate immunity

Immunological Reviews, 2000
Summary: The surfactant‐associated proteins SP‐A and SP‐D are members of a family of host defense lectins, designated collectins. There is increasing evidence that these pulmonary, epithelial‐derived proteins are important components of the innate immune response to microbial challenge and participate in other aspects of immune and inflammatory ...
E, Crouch, K, Hartshorn, I, Ofek
openaire   +2 more sources

Collectins and Pulmonary Host Defense

American Journal of Respiratory Cell and Molecular Biology, 1998
Abstract The surfactant-associated proteins SP-A and SP-D are members of a family of collagenous host defense lectins, designated collectins. There is increasing evidence that these pulmonary epithelial-derived proteins are important components of the innate immune response to microbial challenge, and that they participate in other ...
openaire   +2 more sources

The role of the collectin system in pulmonary defence

Paediatric Respiratory Reviews, 2001
The human collectin system comprises the serum protein, mannose- binding lectin and the hydrophilic surfactant proteins A and D. The three proteins possess structural and functional similarities and are important components of innate immunity. Through a variety of mechanisms, including direct opsonisation and complement activation, they assist in host ...
J, Davies, M, Turner, N, Klein
openaire   +2 more sources

Purification, Quantification, and Functional Analysis of Collectins

2020
Native and recombinant collectins are purified by using mannan-agarose and an anti-collectin antibody column. The use of sandwich enzyme-linked immunosorbent assay (ELISA) with two antibodies against human mannan-binding lectin (MBL) enables elucidation of the collectin concentration in the blood, serum, and plasma.
Katsuki, Ohtani, Nobutaka, Wakamiya
openaire   +2 more sources

Collectins in urinary tract and kidney diseases

International Urology and Nephrology, 2017
The innate immune system serves as the frontline defense against invading pathogens and initiates an inflammatory response to microorganisms. Collectins are C-type lectins that are structurally characterized by a collagen-like sequence and a carbohydrate recognition domain. Moreover, they are widely expressed throughout the body and are involved in the
Yongfang, Qin, Jingjing, Liu, Jiao, Liu, Fengqi, Hu   +3 more
openaire   +2 more sources