Results 81 to 90 of about 5,247 (206)

Surfactant protein D induces immune quiescence and apoptosis of mitogen-activated peripheral blood mononuclear cells [PDF]

, 2016
Surfactant Protein D (SP-D) is an integral molecule of the innate immunity secreted by the epithelial cells lining the mucosal surfaces. Its C-type lectin domain offers pattern recognition functions while it binds to putative receptors on immune cells to
Aghila Rani Koippallil Gopalakrishnan, Akman, Anderson, Anushree Patil, Arancibia, Awasthi, Belkaid, Bettelli, Borron, Borron, Bratcher, Brüll, Contardi, Daniel, de la Fuente, Drutman, Eswari Dodagatta-Marri, Fisher, Gardai, Gargi Thakur, Gelman, Greenwald, Haczku, Henning, Hornung, Hrishikesh Pandit, Iwakura, Kabelitz, Kankakee, Kishore, Koippallil Gopalakrishnan Nair, Komai-Koma, Lin, Liu, Madan, Madan, Madan, Mahajan, Mahajan, Matsumura, Miossec, Mueller, Mukherjee, Mukherjee, O'Garra, Oberley, Ohya, Pandit, Qaseem, Rabinovich, Reynolds, Reynolds, Sano, Senft, Shrive, Syed, Taruna Madan, Thorburn, Uday Kishore, Vinay, Yamazoe   +60 more
core   +1 more source

Genome‐wide DNA methylation profiles in the raphe nuclei of patients with autism spectrum disorder

Psychiatry and Clinical Neurosciences, Volume 79, Issue 7, Page 415-424, July 2025.
Aim Autism spectrum disorder (ASD) has a strong genetic basis, yet its genetic complexities remain elusive. Current research highlights environmental factors and epigenetic processes, such as DNA methylation, as crucial in ASD development. This exploratory study addresses a gap in understanding epigenetic regulation in the dorsal raphe (DR)—a region ...
Keiko Iwata, Kazuhiko Nakabayashi, Keisuke Ishiwata, Kazuhiko Nakamura, Yosuke Kameno, Kenichiro Hata, Hideo Matsuzaki   +6 more
wiley   +1 more source

AIDS patients have increased surfactant protein D but normal mannose binding lectin levels in lung fluid

Respiratory Research, 2007
Background Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV).
Zijlstra Ed, French Neil, Jambo Kondwani C, Gordon Stephen B   +3 more
doaj   +1 more source

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng Ruan   +11 more
wiley   +1 more source

NET balancing: A problem in inflammatory lung diseases

Frontiers in Immunology, 2013
Neutrophil extracellular traps (NETs) are beneficial antimicrobial defense structures that can help fight against invading pathogens in the host. However, recent studies reveal that NETs exert adverse effects in a number of diseases including many lung ...
Olivia Z Cheng, Nades ePalaniyar
doaj   +1 more source

A Study Into Systemic and Oral Levels of Proinflammatory Biomarkers Associated With Endpoints After Active Non‐Surgical Periodontal Therapy

Journal of Clinical Periodontology, Volume 52, Issue 2, Page 188-198, February 2025.
ABSTRACT Aim To analyse whether some selected inflammatory biomarkers collected from venous blood and gingival crevicular fluid (GCF) were associated with the outcome of non‐surgical periodontal therapy. Materials and Methods Two‐hundred and nine patients affected by periodontitis were enrolled in the study, who had undergone steps I and II therapy as ...
Nils Werner, Iris Frasheri, Katrin Heck, Carla Scalia, Vinay Pitchika, Burkhard Summer, Christina Ern, Richard Heym, Falk Schwendicke, Caspar Victor Bumm, Matthias Folwaczny   +10 more
wiley   +1 more source

Alveolar Glycocalyces During Health and Critical Illness

Proteoglycan Research, Volume 3, Issue 1, January-March 2025.
ABSTRACT The alveolus, the functional unit of the lung, is comprised of closely approximated alveolar epithelial and endothelial cells, across which gas exchange occurs. This alveolar septum also includes two substantial, intraluminal extracellular matrices: the alveolar epithelial and endothelial glycocalyces.
Yimu Yang, Eric P. Schmidt
wiley   +1 more source

Molecular Dynamics Simulation of Carbon Nanotube & Pulmonary Surfactant Protein - B Interactions [PDF]

, 2014
Absorption of proteins onto carbon nanotubes is important part of biomedical engineering because it is helpful to fabricate stable, compatible and sensitive scaffold, which is the basic step of fabricating biosensors.
Dharmadhikari, Bhushan V.
core  

Nitrosothiols in the immune system: Signaling and protection [PDF]

, 2013
Antioxidants and Redox Signaling 18.3 (2013): 288-308Significance: In the immune system, nitric oxide (NO) has been mainly associated with antibacterial defenses exerted through oxidative, nitrosative, and nitrative stress and signal transduction through
Alicia Izquierdo-Álvarez, Almudena García-Ortiz, Antonio Martínez-Ruiz, Cottone M, Crouch E, Dimmeler S, Fehsel K, Gordon SA, Graudal NA, Iwata S, Juan M. Serrador, Messina JP, Mori N, Pablo Hernansanz-Agustín, Sales Ibiza, Sato N, Shi YF, Smyth MJ, Sriskandan S, Tagaya Y, Tai XG, Vodovotz Y, Williams MS   +22 more
core   +2 more sources

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic Targets

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a neglected disease affecting around 6 million people, with no effective antiparasitic drugs or vaccines. About 40% of Chagas disease patients develop symptomatic forms in the chronic phase of infection, chronic Chagas cardiomyopathy (CCC) or digestive forms like ...
Amanda Farage Frade, Hélléa Guérin, Joao Paulo Silva Nunes, Luiz Felipe Souza e Silva, Vinicius Moraes de Paiva Roda, Rafael Pedro Madeira, Pauline Brochet, Pauline Andrieux, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto, Alessandro Trentini   +11 more
wiley   +1 more source