Results 101 to 110 of about 162,664 (311)
Advanced Science, EarlyView.We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li +10 more
wiley +1 more source
Advanced Science, EarlyView.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Advanced Science, EarlyView.Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
wiley +1 more source
Advanced Science, EarlyView.Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner +14 more
wiley +1 more source
Emotional Intelligence: a Study on University Students [PDF]
, 2019 Nature bestowed humans with emotions. Emotions are significant predictors of anyone's success. Now Emotional Intelligence is an established phenomenon is under eye of researcher and psychologist. The objectives of this study were (i) to explore the level
Kant, R. (Ravi)
core
Dual‐Strategy Design of Heterojunction‐Enhanced Piezoelectric Hydrogels for Periodontitis Treatment
Advanced Science, EarlyView.This study developed a piezoelectric hydrogel integrating heterojunction enhancement and dual‐salt synergy, combining robust electrical performance with mechanical stability and bioactivity to better match the periodontal microenvironment. Under ultrasound activation, the hydrogel markedly promotes macrophage M2 polarization, thereby reducing the ...
Qiangqiang Zhou +10 more
wiley +1 more source
Education SciencesThis study explores factors influencing the implementation fidelity of the School-Wide Positive Behavior Interventions and Supports (SWPBIS) program, adapted as Inclusive Behavioral Support in Schools (IBIS) in Sweden.
Martin Karlberg
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Collective Teacher Self-Efficacy Scale for Elementary School Teachers
International Journal of Instruction, 2022 Javier Sánchez-Rosas +3 more
openaire +1 more source