Results 61 to 70 of about 5,722 (259)

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Self Efficacy and Collective Efficacy Beliefs of Teachers for Children with Autism

Literacy Information and Computer Education Journal, 2012
Researchers have sought to define teacher efficacy, and done so based on work conducted in the 1970s by the RAND organisation and also Bandura’s Social Cognitive Theory. Efficacy the belief in one’s capabilities to organize and execute the courses of action required to manage prospective situations.
openaire   +1 more source

Teachers’ work ability: a study of relationships between collective efficacy and self-efficacy beliefs

Psychology Research and Behavior Management, 2018
Work ability constitutes one of the most studied well-being indicators related to work. Past research highlighted the relationship with work-related resources and demands, and personal resources. However, no studies highlight the role of collective and self-efficacy beliefs in sustaining work ability.The purpose of this study was to examine whether and
Gloria Guidetti, Sara Viotti, Andreina Bruno, Daniela Converso   +3 more
openaire   +7 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Impact of Professional Learning Addressing Bandura’s Efficacy Sources on Collective Teacher Efficacy

International Dialogues on Education: Past and Present
Despite broad interest in fostering high levels of collective teacher efficacy, inquiries into the intentional development of collective teacher efficacy through professional learning are scarce in the literature.
Stephanie Thomas
doaj  

Teachers’ job engagement: the personal and job resources that matter

Humanities & Social Sciences Communications
This study examines the associations of teachers’ personal and job resources (occupational commitment, self-efficacy, collective efficacy, resilience & adaptability) to job engagement.
Lynn Sheridan, Dennis Alonzo, Hoa Thi Mai Nguyen, Xuesong Andy Gao, Tracy L. Durksen   +4 more
doaj   +1 more source

Effective Principal Leadership Behaviors That Enhance Teacher Collective Efficacy

Education Sciences
This qualitative case study explored teachers’ perceptions regarding the impact of principal leadership behaviors that helped to enhance teacher collective efficacy (TCE).
Robert H. Voelkel, Kyla J. Prusak, Frances Van Tassell   +2 more
doaj   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Unveiling the mediating role of teachers’ self-image in the link between collective efficacy and professional commitment

International Journal of Adolescence and Youth
This study explores the relationships among collective teacher efficacy (CTE), teachers’ self-image, and teacher commitment in Ethiopia, using structural equation modeling with 342 primary and middle school teachers.
Sintayehu Belay, Tadesse Melesse
doaj   +1 more source