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pH-sensitive ZnO/carboxymethyl cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil

International Journal of Biological Macromolecules, 2019
To develop relatively green and ecofriendly smart vehicles for colon-specific drug delivery, carboxymethyl cellulose (CMC) and chitosan (CS) pH-sensitive biopolymers were used in this study. To overcome the weaknesses of CMC carriers, such as poor mechanical performance and an explosive drug release, zinc oxide (ZnO) nanoparticles were incorporated ...
Xiaoxiao, Sun   +8 more
openaire   +2 more sources

Resistant Starch Film-Coated Microparticles for an Oral Colon-Specific Polypeptide Delivery System and Its Release Behaviors

Journal of Agricultural and Food Chemistry, 2014
For the delivery of bioactive components to the colon, an oral colon-specific controlled release system coated with a resistant starch-based film through aqueous dispersion coating process was developed. Starch was modified by a high-temperature-pressure reaction, enzymatic debranching, and retrogradation, resulting in a dramatic increase in the ...
Wenbei, Situ   +3 more
openaire   +2 more sources

Application of 2-hydroxyethyl methacrylate polymers in controlled release of 5-aminosalicylic acid as a colon-specific drug

Journal of Polymer Research, 2007
Acrylic type polymeric systems having degradable ester bonds linked to 5-aminosalicylic acid were synthesized and evaluated as materials for drug delivery. 5-Aminosalicylic acid, as an important drug in the treatment of inflammatory bowel diseases, was linked to 2-hydroxyethyl methacrylate by activated ester methodology in two-step and one-pot ...
Mirzaagha Babazadeh   +2 more
openaire   +1 more source

A novel pH‐sensitive hydrogels for potential colon‐specific drug delivery: Characterization and in vitro release studies

Starch - Stärke, 2011
AbstractStimuli‐responsive hydrogels are extensively investigated to implement new biomedical and pharmaceutical approaches. In this work, novel pH‐sensitive semi‐interpenetrating polymer network (semi‐IPN) hydrogels based on starch and poly(aspartic acid) (PAsp) with potential applicability in the field of pharmaceutics were prepared and characterized.
Changhua Liu, Xianxue Gan, Yanqing Chen
openaire   +1 more source

[Preparation and examination of the vitro releasing of pH-dependent kuijiekang tablet for colon-specific delivery].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2008
To prepare the pH-dependent kuijiekang tablet for colon-specific delivery used in treating the ulcerative colitis and to develop the in vitro release method of kuijiekang tablets.The coating prescription was screened by the in vitro delivery of Puerarin and Berberine hydrochloride.
Rui-zhen, Li   +2 more
openaire   +1 more source

[Preparation of coated tablets of glycyrrhetic acid-HP-beta-cyclodextrin tablets for colon-specific release].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To prepare coated tablets of glycyrrhetinic acid and hydroxypropyl-beta-cyclodextrin (GTA-HP-beta-CYD) inclusion complex tablets for colon-specific release.In order to improve the solubility of GTA, the GTA-HP-beta-CYD inclusion complex was prepared by ultrasonic-lyophilization technique and its formation were characterized by X-ray powder diffraction ...
Qi-Hua, Cui   +2 more
openaire   +1 more source

Adjuvant Therapy for Colon Cancer

Ca-A Cancer Journal for Clinicians, 1997
John S Macdonald
exaly  

Oxaliplatin in the Adjuvant Treatment of Colon Cancer

Ca-A Cancer Journal for Clinicians, 2012
Mary Kay Barton
exaly  

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