Results 201 to 210 of about 9,026,275 (240)
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Journal of Pharmaceutical Sciences, 2010
Despite potential therapeutic efficacy of resveratrol on colitis and colorectal cancer, rapid absorption and metabolism at the upper gastro-intestinal (GI) tract prevent its clinical application. To overcome this, we attempted to develop colon-specific multi-particulate calcium-pectinate (Ca-pectinate) formulations of resveratrol.
Das, S., Ng, K.
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Despite potential therapeutic efficacy of resveratrol on colitis and colorectal cancer, rapid absorption and metabolism at the upper gastro-intestinal (GI) tract prevent its clinical application. To overcome this, we attempted to develop colon-specific multi-particulate calcium-pectinate (Ca-pectinate) formulations of resveratrol.
Das, S., Ng, K.
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Journal of Biomedical Materials Research Part A
AbstractThe worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity and unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers have shown promise as carriers.
Darshan Bhirud +2 more
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AbstractThe worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity and unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers have shown promise as carriers.
Darshan Bhirud +2 more
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Materials Science and Engineering: C, 2018
In recent years, there has been a significant increase in strategies for the development of small intestine (and colon)-specific oral drug-delivery systems to maximize the efficiency of therapeutic agents and reduce side effects. However, only a few strategies are capable of working in the complicated environment of the human intestinal tract.
Ji-Hye Kang +4 more
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In recent years, there has been a significant increase in strategies for the development of small intestine (and colon)-specific oral drug-delivery systems to maximize the efficiency of therapeutic agents and reduce side effects. However, only a few strategies are capable of working in the complicated environment of the human intestinal tract.
Ji-Hye Kang +4 more
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Biomacromolecules, 2007
A novel pH-sensitive and biodegradable composite hydrogel, based on a methacrylated and succinic derivative of dextran, named Dex-MA-SA, and a methacrylated and succinic derivative of alpha,beta-poly( N-2-hydroxyethyl)- DL-aspartamide (PHEA), named PHM-SA, was produced by photocross-linking. The goal was to obtain a colon-specific drug delivery system,
CASADEI, Maria Antonietta +4 more
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A novel pH-sensitive and biodegradable composite hydrogel, based on a methacrylated and succinic derivative of dextran, named Dex-MA-SA, and a methacrylated and succinic derivative of alpha,beta-poly( N-2-hydroxyethyl)- DL-aspartamide (PHEA), named PHM-SA, was produced by photocross-linking. The goal was to obtain a colon-specific drug delivery system,
CASADEI, Maria Antonietta +4 more
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AAPS PharmSciTech, 2020
In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional formulas. A colon-specific osmotic pump capsule (COPC) of Compound Danshen was prepared using a semipermeable shell with ...
Xiangjiang, Nie +11 more
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In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional formulas. A colon-specific osmotic pump capsule (COPC) of Compound Danshen was prepared using a semipermeable shell with ...
Xiangjiang, Nie +11 more
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Current Drug Delivery, 2017
Recent immunologic data implicates involvement of mucosal immune cells of the intestine like eosinophils and mast cells to be functionally involved in the pathogenesis of UC. Mast cell activation is followed by increased secretion and elevated tissue concentration of histamine.
Priyanka, Singh, Suneela S, Dhaneshwar
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Recent immunologic data implicates involvement of mucosal immune cells of the intestine like eosinophils and mast cells to be functionally involved in the pathogenesis of UC. Mast cell activation is followed by increased secretion and elevated tissue concentration of histamine.
Priyanka, Singh, Suneela S, Dhaneshwar
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International Journal of Pharmaceutics, 2011
The aim of this work is to design, prepare and characterize L-lysine based prodrugs capable of targeting 6-mercaptopurine to the colon, an anti-tumor and immunosuppressant drug, and 5-aminosalicylic acid (5-ASA), drug of choice for inflammatory bowel disease (IBD).
Trombino S. +5 more
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The aim of this work is to design, prepare and characterize L-lysine based prodrugs capable of targeting 6-mercaptopurine to the colon, an anti-tumor and immunosuppressant drug, and 5-aminosalicylic acid (5-ASA), drug of choice for inflammatory bowel disease (IBD).
Trombino S. +5 more
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Journal of Controlled Release, 1997
Abstract A multiparticulate system with the potential for site-specific delivery to the colon has been investigated. Gelation of droplets of amidated pectin solutions in the presence of calcium is the basis of the method of preparation. Two drugs, indomethacin and sulphamethoxazole were successfully incorporated into the beads.
Munjeri, O, Collett, JH, Fell, J.T.
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Abstract A multiparticulate system with the potential for site-specific delivery to the colon has been investigated. Gelation of droplets of amidated pectin solutions in the presence of calcium is the basis of the method of preparation. Two drugs, indomethacin and sulphamethoxazole were successfully incorporated into the beads.
Munjeri, O, Collett, JH, Fell, J.T.
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[Study on preparation of matrine double-sensitive colon-specific pellets and in vitro release].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014To prepare matrine double-sensitive colon-specific pellets and study the factors affecting its quality and evaluateing the colon-specific effects of preparation.Matrine enzyme-sensitive pellets core were prepared by carboxymethyl konjac glucomannan as the main carrier material, and coated the core by acrylic resin II and III to prepare matrine double ...
Yong-Gang, Zhang, Jing, Jie
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AAPS PharmSciTech, 2020
Borneol can enhance the bioavailability of several other drugs by opening the blood-brain barrier and inhibiting P-glycoprotein (P-gp) efflux. However, whether borneol will impact the bioavailability and the mechanism of compound Danshen colon-specific osmotic pump capsule (CDCOPC) remains unclear.
Liangyu, Shao +10 more
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Borneol can enhance the bioavailability of several other drugs by opening the blood-brain barrier and inhibiting P-glycoprotein (P-gp) efflux. However, whether borneol will impact the bioavailability and the mechanism of compound Danshen colon-specific osmotic pump capsule (CDCOPC) remains unclear.
Liangyu, Shao +10 more
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