Results 191 to 200 of about 9,026,275 (240)

Preparation of baicalin colon-specific solid dispersion and evaluation on its in vitro release

China Journal of Chinese Materia Medica, 2014
To prepare pH-dependent baicalin colon-specific solid dispersion, with the aim of colon-specific delivery and rapid drug release.Baicalin-eudragit S100 solid dispersion was prepared by using the solvent method. The microscopic structure and physicochemical properties were analyzed by using differential scanning calorimetry (DSC), scanning electron ...
Hong-Mei, Yan, Zhen-Hai, Zhang, Yan-Rong, Jiang, Dong-Mei, Ding, E, Sun, Xiao-Bin, Jia   +5 more
openaire   +3 more sources

Influence of different chitosan salts on the release of sodium diclofenac in colon-specific delivery

International Journal of Pharmaceutics, 2002
Chitosan (CH) was dissolved in aqueous solutions containing aspartic, glutamic, hydrochloric, lactic and citric acids to obtain different chitosan salts. Chitosan salts were collected from the solutions by spray-drying and the powders obtained were mixed with Sodium Diclofenac (SD), taken as a model anti-inflammatory drug. This study evaluated in vitro
Orienti I., Cerchiara T., Luppi B., Bigucci F., Zuccari G., Zecchi V.   +5 more
openaire   +3 more sources

Release characteristics of salmon calcitonin from dextran hydrogels for colon-specific delivery

European Journal of Pharmaceutics and Biopharmaceutics, 2007
Biodegradable dextran hydrogels were synthesized by crosslinking dextran (T-70) with epichlorohydrin (ECH) for the in vitro colon-specific delivery of salmon calcitonin (sCT). Crosslinking reaction was performed in 2.8 M NaOH solution both in the presence and absence of ethanol at 10 and 23 degrees C.
Gumusderelioglu, Menemse, Orbey, M. Tevfik, Basan, Hasan   +2 more
openaire   +4 more sources

[Evaluation on preparation process of brevisapin colon-specific tables and its in vitro release].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013
To prepare the new traditional Chinese medicine preparation--pH-dependent brevisapin colon-specific tablets, and investigate its in vitro release, in order to discuss the feasibility of preparing colon-targeted traditional Chinese medicines.With scutellarin, the active ingredient in brevisapin, as the evaluation index, coating prescriptions of the ...
Yan-Ling, Li, Jin-Yu, Wang, De-Bin, Yang, Mei-Hong, Dong, Yan, Tong   +4 more
openaire   +3 more sources

Development and potential application of an oral ColoPulse infliximab tablet with colon specific release: A feasibility study

International Journal of Pharmaceutics, 2016
The monoclonal antibody infliximab is one of the cornerstones in the treatment of Crohn's disease. Local delivery of infliximab would be an alternative to overcome the inherent disadvantages of intravenous therapy. For this purpose 5mg infliximab tablets were developed.
Maurer, Jacoba M., Hofman, Susan, Schellekens, Reinout C. A., Tonnis, Wouter F., Dubois, Annelien O. T., Woerdenbag, Herman J., Hinrichs, Wouter L. J., Kosterink, Jos G. W., Frijlink, Henderik W.   +8 more
openaire   +2 more sources

Methotrexate Bearing Calcium Pectinate Microspheres: A Platform to Achieve Colon-Specific Drug Release

Current Drug Delivery, 2008
In the present work calcium pectinate (Ca-pectinate) microspheres were prepared to deliver methotrexate in the environment of colon. Calcium pectinate microspheres were prepared by modified emulsification method using calcium chloride as cross linker. All the formulations were evaluated for various physicochemical parameters.
M, Chaurasia, M K, Chourasia, Nitin K, Jain, A, Jain, V, Soni, Y, Gupta, S K, Jain   +6 more
openaire   +2 more sources

Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil

International Journal of Pharmaceutics, 2020
Targeting bioactives selectively to diseased sites is one of the most challenging aspects of cancer therapy. Herein, fabrication of colonic enzyme-responsive dextran based oligoester crosslinked nanoparticles is reported for the controlled release of 5-fluorouracil (5-FU) - an anticancer drug. The 5-FU drug loaded nanoparticles (DNPs, size ~237 ± 25 nm,
Mehwish Abid, Muhammad Naveed, Iqra Azeem, Amir Faisal, Muhammad Faizan Nazar, Basit Yameen   +5 more
openaire   +2 more sources

Oral pectin/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease

Carbohydrate Polymers, 2023
Inflammatory bowel disease (IBD) is a chronic, life quality-reducing disease with no cures available yet. To develop an effective medication suitable for long-term use is an urgent but unmet need. Quercetin (QT) is a natural dietary flavonoid with good safety and multifaceted pharmacological activities against inflammation.
Shisuo, Jing, Huayuan, Chen, Ergang, Liu, Meng, Zhang, Feng, Zeng, Huan, Shen, Yuefei, Fang, Bahtiyor, Muhitdinov, Yongzhuo, Huang   +8 more
openaire   +2 more sources

Design and evaluation of pH modulated controlled release matrix systems for colon specific delivery of indomethacin

Die Pharmazie, 2008
Indomethacin, a potent non steroidal anti-inflammatory drug (NSAID), is indicated for the local treatment of colorectal carcinoma. The aim of the present study was to design and investigate various matrix systems for controlled and site specific delivery of indomethacin to the colon.
Chandran, S., Asghar, L. F. A.
openaire   +2 more sources

Design, synthesis and ex-vivo release studies of colon-specific polyphosphazene–anticancer drug conjugates

Bioorganic & Medicinal Chemistry, 2014
Colon-specific azo based polyphosphazene-anticancer drug conjugates (11-18) have been synthesized and evaluated by ex-vivo release studies. The prepared polyphosphazene drug conjugates (11-18) are stable in acidic (pH=1.2) buffer which showed that these polymer drug conjugates are protected from acidic environment which is the primary requirement of ...
Rajiv, Sharma, Ravindra K, Rawal, Manav, Malhotra, A K, Sharma, T R, Bhardwaj   +4 more
openaire   +2 more sources