Results 61 to 70 of about 3,109,474 (268)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Prognostic Value of Psoas Major Muscle Volume in Assessing Sarcopenia in Elderly Patients With Rectal Cancer

Annals of Gastroenterological Surgery
Background This study aimed to evaluate the clinical utility and prognostic significance of sarcopenia classification based on the psoas major muscle volume index (PVI) in elderly patients with rectal cancer.
Gen Tsujio, Shoichi Manabe, Akio Shiomi, Yusuke Tanaka, Shunsuke Kasai, Tadahiro Kojima, Takahiro Igaki, Yukihiro Mori, Akifumi Notsu   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Safety and Efficacy of Pelvic Reinforcement Procedure for Preventing Postoperative Perineal Hernia After Robotic Abdominoperineal Resection: A Single‐Center, Retrospective Cohort Study

Annals of Gastroenterological Surgery
Aim Few reports have described pelvic reinforcement procedure (PRP) to prevent perineal hernia (PH) in robotic abdominoperineal resection (Ro‐APR) for rectal cancer. This study aimed to investigate the safety and efficacy of PRP in Ro‐APR.
Yoshihiro Sakai, Shunsuke Kasai, Akio Shiomi, Shoichi Manabe, Yusuke Yamaoka, Yusuke Tanaka, Takahiro Igaki, Hiroyasu Kagawa, Yusuke Kinugasa   +8 more
doaj   +1 more source

Comparison of One versus Two Fecal Immunochemical Tests in the Detection of Colorectal Neoplasia in a Population-Based Colorectal Cancer Screening Program

Canadian Journal of Gastroenterology and Hepatology, 2016
Objective. To determine the positive predictive value (PPV) of two versus one abnormal FIT in the detection of colorectal neoplasia in a Canadian population. Methods. Three communities enrolled in a colorectal cancer (CRC) screening pilot program from 01/
Sarvenaz Moosavi, Robert Enns, Laura Gentile, Lovedeep Gondara, Colleen McGahan, Jennifer Telford   +5 more
doaj   +1 more source

Intermittent Chemoprevention of Colon Cancer

, 2015
This video shows the advantage of intermittent pulse schedules compared to constant schedules, for the chemoprevention of colon cancer in a computer simulation of cell dynamics in human colon crypts.Supplemental data for a manuscript prepared for ...
Axelrod, David E.
core   +1 more source

Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells [PDF]

, 2006
Swiss Cancer League, Swiss National Science Foundation and SNSF NCCR Molecular Oncology ProgrammeBackground: The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer.
Homicsko, Krisztian, Pittet Anne-Laure, Christophe Fuerer, Lukashev, Alexander N., Homicsko Krisztian, Alexander N Lukashev, Fuerer Christophe, Anne-Laure Pittet, Iggo, Richard D., Fuerer, Christophe, Pittet, Anne-Laure, Richard D Iggo, Lukashev Alexander N, Iggo Richard D, Krisztian Homicsko, Iggo, R.D., Fuerer, C., Homicsko, K., Pittet, A.L., Lukashev, A.N.   +19 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of autonomic nervous system resection extent on urinary dysfunction in robotic rectal cancer surgery

Annals of Gastroenterological Surgery
Aim We investigated whether autonomic nervous system resection during robotic rectal surgery contributes to urinary dysfunction and to what extent. Methods This retrospective cohort study included patients who underwent rectal surgery for primary rectal ...
Sodai Arai, Hiroyasu Kagawa, Akio Shiomi, Yusuke Yamaoka, Shoichi Manabe, Chikara Maeda, Yusuke Tanaka, Shunsuke Kasai, Akifumi Notsu, Yusuke Kinugasa   +9 more
doaj   +1 more source

Feasibility of Consensus Molecular Subtype Classification of Colorectal Cancer Using Preoperative Biopsy Specimens: A Prospective Pilot Study (COLLAB Study)

Journal of the Anus, Rectum and Colon
Background: The consensus molecular subtype (CMS) classification stratifies colorectal cancer (CRC) into four groups based on gene expression, offering potential for tailored therapy.
Shunsuke Kasai, Keiichi Hatakeyama, Akio Shiomi, Kinichi Hotta, Shoichi Manabe, Kenichiro Imai, Yusuke Tanaka, Tadahiro Kojima, Keiichi Ohshima, Kenichi Urakami, Yasuto Akiyama, Yusuke Kinugasa   +11 more
doaj   +1 more source