Results 51 to 60 of about 982,011 (308)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Blue Star Healthy Colon Initiative [PDF]

, 2013
IMPACT. 1: This collaborative effort has: Raised awareness about the burden of colon cancer. Provided education on prevention and early detection of colon cancer.
Fickle, Darla
core   +3 more sources

Safety and Efficacy of Pelvic Reinforcement Procedure for Preventing Postoperative Perineal Hernia After Robotic Abdominoperineal Resection: A Single‐Center, Retrospective Cohort Study

Annals of Gastroenterological Surgery
Aim Few reports have described pelvic reinforcement procedure (PRP) to prevent perineal hernia (PH) in robotic abdominoperineal resection (Ro‐APR) for rectal cancer. This study aimed to investigate the safety and efficacy of PRP in Ro‐APR.
Yoshihiro Sakai, Shunsuke Kasai, Akio Shiomi, Shoichi Manabe, Yusuke Yamaoka, Yusuke Tanaka, Takahiro Igaki, Hiroyasu Kagawa, Yusuke Kinugasa   +8 more
doaj   +1 more source

Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro [PDF]

, 2016
A novel anti-tumor agent 4-thio-5-(2′′-thienyl)uridine (6) was synthesized and the in vitro cytotoxicity activity against mice colon cancer cells (MC-38) and human colon cancer cells (HT-29) was evaluated by MTT assay.
Li, Depeng, Ma, Kedong, Qin, Jianzhong, Xu, Yaozhong, Zhang, Xiaohui   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effect of autonomic nervous system resection extent on urinary dysfunction in robotic rectal cancer surgery

Annals of Gastroenterological Surgery
Aim We investigated whether autonomic nervous system resection during robotic rectal surgery contributes to urinary dysfunction and to what extent. Methods This retrospective cohort study included patients who underwent rectal surgery for primary rectal ...
Sodai Arai, Hiroyasu Kagawa, Akio Shiomi, Yusuke Yamaoka, Shoichi Manabe, Chikara Maeda, Yusuke Tanaka, Shunsuke Kasai, Akifumi Notsu, Yusuke Kinugasa   +9 more
doaj   +1 more source

A reciprocal feedback between colon cancer cells and Schwann cells promotes the proliferation and metastasis of colon cancer

Journal of Experimental & Clinical Cancer Research, 2022
Background Research has indicated that the emergence of Schwann cells around premalignant lesions of colon cancer might be an early indicator promoting the onset of tumorigenesis.
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao   +13 more
doaj   +1 more source

Superficial‑type endobronchial metastases from colon cancer : A case report [PDF]

, 2014
Certain internal malignancies, including colon cancer, can develop endobronchial metastasis. The present study reports a case of colon cancer with superficial‑type endobronchial metastases in a 76‑year‑old male.
Hizawa Nobuyuki, Kagohashi Katsunori, Kawaguchi Mio, Kurishima Koichi, Miyazaki Kunihiko, Ohara Gen, Satoh Hiroaki, Shiozawa Toshihiro, Takayashiki Norio, Tamura Tomohiro, 佐藤 浩昭, 川口 未央, 檜澤 伸之, 籠橋 克紀, 髙屋敷 典生   +14 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mutational signatures in colon cancer. [PDF]

, 2019
ObjectiveRecently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often.
Marjoram, Paul, Pandey, Priyatama, Shibata, Darryl, Siegmund, Kimberly D, Yang, Zhi   +4 more
core