Results 51 to 60 of about 3,109,474 (268)

Short-term and long-term outcomes after robotic radical surgery for rectal gastrointestinal stromal tumor

BMC Surgery
Background The optimal approach for ensuring both complete resection and preservation of anal function in rectal gastrointestinal stromal tumor (GIST) remains unknown.
Chikara Maeda, Yusuke Yamaoka, Akio Shiomi, Hiroyasu Kagawa, Hitoshi Hino, Shoichi Manabe, Chen Kai, Kenji Nanishi   +7 more
doaj   +1 more source

Conservative treatment of colon cancer

, 2021
Colon cancer is a type of cancer that develops or originates from the colon and it is characterised by a high morbidity and mortality rate. Colorectal is the 3rd most common cancer in the world affecting both men and women.
Bibak, Behnam
core  

Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer [PDF]

, 2009
After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes' B and ...
Foulis, A.K., R F McKee, McMillan, D.C., A K Foulis, Maxwell, F., McKee, R.F., C S D Roxburgh, F Maxwell, Crozier, J.E.M., Roxburgh, C.S.D., Anderson, J.H., J H Anderson, D C McMillan, P G Horgan, J E M Crozier, Horgan, P.G., Brown, J., J Brown   +17 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Clinicopathological and mutational analyses of colorectal cancer with mutations in the POLE gene

Cancer Medicine, 2019
Here, we investigated the clinicopathological and mutation profiles of colorectal cancer (CRC) with POLE mutations. Whole‐exome sequencing was performed in 910 surgically resected primary CRCs.
Hitoshi Hino, Akio Shiomi, Masatoshi Kusuhara, Hiroyasu Kagawa, Yushi Yamakawa, Keiichi Hatakeyama, Takanori Kawabata, Takuma Oishi, Kenichi Urakami, Takeshi Nagashima, Yusuke Kinugasa, Ken Yamaguchi   +11 more
doaj   +1 more source

Predictive biomarkers of colon cancer immunotherapy: Present and future

Frontiers in Immunology, 2022
Immunotherapy has revolutionized colon cancer treatment. Immune checkpoint inhibitors (ICIs) have shown clinical benefits for colon cancer patients, especially those with high microsatellite instability (MSI-H).
Wanting Hou, Cheng Yi, Hong Zhu
doaj   +1 more source

Freeze-Dried Ham Promotes Azoxymethane-Induced Mucin-Depleted Foci and Aberrant Crypt Foci in Rat Colon [PDF]

, 2010
Processed and red meat consumption is associated with the risk of colorectal cancer. Meta-analyses have suggested that the risk associated with processed meat is higher. Most processed meats are cured and cooked, which leads to formation of free nitrosyl
Françoise Guéraud, Sylviane Taché, Taché, Sylviane, Ossama Allam, Santarelli, Raphaëlle, L., Charton, Michael, Denis E. Corpet, Chartron, Mickael, Pierre, Fabrice, Allam, Ossama, Naud, Nathalie, Pierre, Fabrice H.F., Guéraud, Françoise, Nathalie Naud, Santarelli, Raphaëlle L., Corpet, Denis E., Raphaëlle L. Santarelli, Fabrice H. F. Pierre   +17 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

Cancer Cell International, 2021
Background Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon cancer is still unclear. The aim of
Jiwei Wang, Song Li, Honglang Li, Xiaoshuang Zhou, Huabin Wen, Bin Lai   +5 more
doaj   +1 more source

A clinical risk score to predict 3-, 5- and 10-year survival in patients undergoing surgery for Dukes B colorectal cancer [PDF]

, 2010
<p>Background: The prognosis of patients with Dukes stage B colorectal cancer is unpredictable and there is continuing interest in simply and reliably identifying patients at high risk of developing recurrence and dying of their disease. The aim of
D S Morrison, McMillan, D.C., D C McMillan, McArdle, C.S., Morrison, D.S., C S McArdle   +5 more
core   +1 more source