Results 51 to 60 of about 9,867,423 (273)

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Scientific Reports, 2018
MCC950 a potent, highly specific small molecule inhibitor of canonical and noncanonical activation of NLRP3 inflammasome has been evaluated in a multitude of NLRP3 driven inflammatory diseases.
A. P. Perera, R. Fernando, Tanvi Shinde, R. Gundamaraju, Benjamin Southam, S. Sohal, A. Robertson, K. Schroder, D. Kunde, R. Eri   +9 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Short-term exposure to high relative humidity increases blood urea and influences colonic urea-nitrogen metabolism by altering the gut microbiota

Journal of Advanced Research, 2022
Introduction: Colonic urea-nitrogen metabolites have been implicated in the pathogenesis of certain diseases which can be affected by environmental factors.
Hongmei Yin, Yadong Zhong, Hui Wang, Jielun Hu, Shengkun Xia, Yuandong Xiao, Shaoping Nie, Mingyong Xie   +7 more
doaj   +1 more source

Colonic Butyrate-Producing Communities in Humans: an Overview Using Omics Data

mSystems, 2017
Studies focusing on taxonomic compositions of the gut microbiota are plentiful, whereas its functional capabilities are still poorly understood. Specific key functions deserve detailed investigations, as they regulate microbiota-host interactions and ...
M. Vital, A. Karch, D. Pieper
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A Study on the Relationship between Dietary Patterns and Prevalence of Irritable Bowel Syndrome

پزشکی بالینی ابن سینا, 2015
Introduction & Objective: Although several dietary factors have been reported to alleviate or ag-gravate the symptoms of irritable bowel syndrome (IBS), no information is available linking dietary patterns to irritable bowel syndrome.
Omid Sadeghi, Seyyed Saeed Khayyatzadeh, Ahmad Esmaillzadeh, Ammar Hasanzadeh Keshteli, Peyman Adibi   +4 more
doaj  

COLONIC IRRIGATION AND AGING: HYPOTHETICAL INSIGHTS INTO INFLAMMATION REDUCTION

Anti-Aging Eastern Europe
Colonic irrigation (colon hydrotherapy) is a procedure where water is applied to clean the colon of the contents it holds. Colonic irrigation has a theoretical rationale for improving systemic inflammation and gastrointestinal health.
Ilke Coskun Benlidayi
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Frequency of Thyroid Nodules among Patients with Colonic Polyps

Gastroenterology Research and Practice, 2012
Aim. Colonic polyps and thyroid nodules are common diseases and their frequency increases with age. In the literature, there is no study investigating the coexistence of colonic polyps and thyroid nodules.
Cevdet Duran, Huseyin Savas Gokturk, Mustafa Kulaksizoglu, Suleyman Bakdik, Gulhan Kanat Unler, Mustafa Erbayrak, Guven Ozkaya, Baris Onder Pamuk, Mustafa Sait Gonen   +8 more
doaj   +1 more source