Results 111 to 120 of about 1,557 (180)

Interferon‐gamma signaling drives epithelial TNF‐alpha receptor‐2 expression during colonic tissue repair

The FASEB Journal, Volume 38, Issue 16, 31 August 2024.
Interferon‐gamma (IFNγ) exhibits a dual role in colonic tissue repair by promoting TNF‐alpha receptor 2 (TNFRSF1B) expression on intestinal epithelial cells (IEC) after injury. In vitro studies show IFNγ induces a STAT1‐dependent increase in TNFR2, while in vivo and in situ analyses reveal elevated Tnfrsf1b mRNA levels in colonic wounds.
Sean Watson, Rodolfo I. Cabrera‐Silva, Charles A. Parkos, Asma Nusrat, Miguel Quiros   +4 more
wiley   +1 more source

Host-microbe interaction in the gastrointestinal tract [PDF]

, 2017
The gastrointestinal tract is a highly complex organ in which multiple dynamic physiological processes are tightly coordinated while interacting with a dense and extremely diverse microbial population.
Abrams G.D., Benveniste J., Benveniste J., Carabotti M., Guenet J.L., Iwai H., Kulkarni D.H., Marshall B., PastuBa A., Shroff K.E., Sprinz H.   +10 more
core   +1 more source

Near-Infrared In Vivo Imaging of Claudin-1 Expression by Orthotopically Implanted Patient-Derived Colonic Adenoma Organoids

Diagnostics
Background: Claudin-1 becomes overexpressed during the transformation of normal colonic mucosa to colorectal cancer (CRC). Methods: Patient-derived organoids expressed clinically relevant target levels and genetic heterogeneity, and were established from
Sangeeta Jaiswal, Fa Wang, Xiaoli Wu, Tse-Shao Chang, Ahmad Shirazi, Miki Lee, Michael K. Dame, Jason R. Spence, Thomas D. Wang   +8 more
doaj   +1 more source

Interleukin 22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells [PDF]

, 2019
Objective - The functional role of interleukin-22 (IL22) in chronic inflammation is controversial and mechanistic insights into how it regulates target tissue are lacking.
Afzali, B, Bewick, GA, Cozzetto, D, Digby-Bell, J, Friedman, J, Kaser, A, Lavender, P, Li, K, Lord, GM, MacDonald, TT, Minns, DH, Mohamed, R, Pantazi, E, Parker, A, Pavlidis, P, Pin, C, Powell, Nicholas, Savelijeva, S, Stolarczyk, E, Tsamaki, A, Tsui, T, Yang, F   +21 more
core   +5 more sources

Role of Notch1 in acute colitis and colitis associated cancer [PDF]

, 2019
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes chronic inflammation and ulcers affecting the innermost layer of the colon. Almost 1 million people suffer from UC in the United States.
Alcala, Adani Pujada
core   +2 more sources

Self-renewing Monolayer of Primary Colonic or Rectal Epithelial CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Three-dimensional organoid culture has fundamentally changed the in vitro study of intestinal biology enabling novel assays; however, its use is limited because of an inaccessible luminal compartment and challenges to data gathering in
Yuli Wang, Matthew DiSalvo, Dulan B. Gunasekara, Johanna Dutton, Angela Proctor, Michael S. Lebhar, Ian A. Williamson, Jennifer Speer, Riley L. Howard, Nicole M. Smiddy, Scott J. Bultman, Christopher E. Sims, Scott T. Magness, Nancy L. Allbritton   +13 more
doaj   +1 more source

Histone Demethylase kdm5d Upregulation Drives Sex Differences in Colon Cancer [PDF]

, 2023
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular and genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones1. Such sex differences are particularly
Akdemir, Kadir, Chakravarti, Deepavali, DePinho, Ronald A, Dunner, Kenneth, Horner, James W, Hsu, Wen-Hao, Jiang, Shan, Khanduri, Isha, LaBella, Kyle A, Lan, Zhengdao, Lee, Rumi, Li, Jiexi, Liao, Wenting, Liu, Jielin, Shang, Xiaoying, Shim, Hong Seok, Slotnik, Max, Spring, Denise J, Terranova, Christopher, Wang, Y Alan, Wu, Chang-Jiun, Xu, Xueping, Yoshihama, Yohei   +22 more
core   +1 more source

Abstract

JPGN Reports, Volume 6, Issue S2, Page S1-S814, September 2025.
wiley   +1 more source

MYADM binds human parechovirus 1 and is essential for viral entry [PDF]

Human parechoviruses (PeV-A) are increasingly being recognized as a cause of infection in neonates and young infants, leading to a spectrum of clinical manifestations ranging from mild gastrointestinal and respiratory illnesses to severe sepsis and ...
Carette, Jan E, Ding, Siyuan, Greenberg, Harry B, Kim, Youlim, Qiao, Wenjie, Richards, Christopher M, Zengel, James R   +6 more
core   +2 more sources

The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction

Inflammatory Bowel Diseases, 2019
AbstractBackgroundAlterations to epithelial tight junctions can compromise the ability of the epithelium to act as a barrier between luminal contents and the underlying tissues, thereby increasing intestinal permeability, an early critical event in inflammatory bowel disease (IBD).
Sayoc-Becerra, Anica, Krishnan, Moorthy, Fan, Shujun, Jimenez, Jossue, Hernandez, Rebecca, Gibson, Kyle, Preciado, Reyna, Butt, Grant, McCole, Declan F   +8 more
openaire   +5 more sources