Results 171 to 180 of about 1,557 (180)

Heavy Metal-Laden Particulate Dust Alters Transcriptional Regulation in Human Colonoids

Physiology
Chronic heavy metals exposure in the southwestern United States co-occurs with greater incidences of metabolic and digestive diseases, particularly in the Indigenous and Hispanic populations. There is a need to understand how particulate heavy metals drive this dysbiotic state and propose a molecular explanation as a result of these exposures ...
Lidia Appell, Roger Atanga, Julie In
openaire   +1 more source

Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids.

Journal of visualized experiments : JoVE, 2023
The intestinal epithelium plays an essential role in human health, providing a barrier between the host and the external environment. This highly dynamic cell layer provides the first line of defense between microbial and immune populations and helps to modulate the intestinal immune response.
Erin, Crawford, Heather L, Mentrup, Elizabeth A, Novak, Kevin P, Mollen   +3 more
openaire   +1 more source

P0054 Human colonoid-derived monolayers and Caco-2: comparative analysis of inflammatory responses

Journal of Crohn's and Colitis
Abstract Background Given the increasing incidence of inflammatory bowel diseases, there is a growing need for reliable preclinical models that replicate the inflamed intestinal epithelium. Immortalized Caco-2 cells are widely considered the standard in vitro model for intestinal studies, but human ...
M L Chiara, I A Parente, L Flammini, V Martina, F Vacondio, G Federica, G L de’Angelis, B Elisabetta, S Bertoni   +8 more
openaire   +1 more source

Proteomic and Transcriptomic Analysis of Human Colonoids Exposed to Bacterial Serine Protease, EspP

Endocrinology
Abstract Text Gut regeneration mechanisms remain an important, yet elusive, facet of intestinal injury research. The intestinal epithelium must be intact for critical gut functions to remain in place, yet injury via microbe interactions or environmental toxicants is common. EspP is a potent serine.
Myranda Thompson, Lidia Appell, Roger Atanga, Julie In   +3 more
openaire   +1 more source

Live cells infected with Enterovirus A71 are specifically extruded from human colonoids

Nature Microbiology, 2023
openaire   +2 more sources

P-305 Oxidized-LDL promotes colorectal cancer progression and growth of human colonoides

Annals of Oncology, 2022
E. González-Horta, Y. Vargas, J. Burgueño, M. Abreu, J. Toledo   +4 more
openaire   +1 more source

Mo1745 IMPACT OF SULFORAPHANE ON GENE EXPRESSION IN 3D HUMAN COLONOIDS

Gastroenterology
Gabriel Hanson, Mariska Batavia, Maria Murach, Craig A. Mckinney, Glynis L. Kolling, Michael J. Rosen, Jason Papin, Sean Moore   +7 more
openaire   +1 more source

Genomic characterization of cancer stem cells derived colonoids – a pilot study

2016
Borys, Agnieszka, Paweł Wołkow, Gracjan Wątor, Michał Seweryn   +3 more
openaire   +1 more source

Sa1218 ANOXIA/ CYTOKINE-INDUCED INJURY MODEL DEPICTS INTESTINAL EPITHELIAL HOMEOSTASIS IN COLONOIDS

Gastroenterology
Corina Miko, Jain Kim, Younggeon Jin
openaire   +1 more source

Su1294: AUTOPHAGY IN COLONIC MUCUS SECRETION IN HUMAN ADULT STEM CELL DERIVED COLONOIDS

Gastroenterology
Manmeet Rawat, Gulshan Parasher, Thomas Y. Ma   +2 more
openaire   +1 more source