Results 21 to 30 of about 1,557 (180)

Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine ColitisSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Inflammatory bowel disease is associated with intestinal energetic derangements, including reduced creatine kinase (CK) expression.
Geetha Bhagavatula, Corey S. Worledge, Ciara Schaepe, Emily M. Murphy, Rane M. Neuhart, J. Scott Lee, Ian Cartwright, Sean P. Colgan, Caroline H.T. Hall   +8 more
doaj   +2 more sources

CFTR modulators response of S737F and T465N CFTR variants on patient-derived rectal organoids [PDF]

Orphanet Journal of Rare Diseases
Background Predictions based on patient-derived materials of CFTR modulators efficacy have been performed lately in patient-derived cells, extending FDA-approved drugs for CF patients harboring rare variants.
Karina Kleinfelder, Paola Melotti, Anca Manuela Hristodor, Cristina Fevola, Giovanni Taccetti, Vito Terlizzi, Claudio Sorio   +6 more
doaj   +2 more sources

Canine intestinal organoids as a platform for studying MHC class II expression in epithelial cells [PDF]

BMC Molecular and Cell Biology
Backgrounds The interplay between intestinal epithelial cells (IECs), the immune system, and the gut microbiome is pivotal for maintaining gastrointestinal homeostasis and mediating responses to ingested antigens.
Meg Nakazawa, Itsuma Nagao, Yoko M. Ambrosini   +2 more
doaj   +2 more sources

Bacterial attachment and junctional transport function in induced apical-out polarized and differentiated canine intestinal organoids [PDF]

Frontiers in Veterinary Science
Dogs are increasingly recognized as valuable large animal models for understanding human intestinal diseases, as they naturally develop conditions similar to those in humans, such as Enterohemorrhagic E.
Shino Yoshida, Meg Nakazawa, Minae Kawasaki, Yoko M. Ambrosini   +3 more
doaj   +2 more sources

Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity.

PLoS ONE, 2019
Background and aimsThe goal of the study was to assess calcium alone and Aquamin, a multi-mineral natural product that contains magnesium and detectable levels of 72 trace elements in addition to calcium, for capacity to affect growth and differentiation
Durga Attili, Shannon D McClintock, Areeba H Rizvi, Shailja Pandya, Humza Rehman, Daniyal M Nadeem, Aliah Richter, Dafydd Thomas, Michael K Dame, Danielle Kim Turgeon, James Varani, Muhammad N Aslam   +11 more
doaj   +3 more sources

Obese Adipose Tissue Extracellular Vesicles Activate Mitochondrial Fatty Acid β-oxidation to Drive Colonic StemnessSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Patients with obesity and mouse models of obesity exhibit abnormalities in intestinal epithelial cells, including enhanced stemness.
Parsa S. Haque, Desiree Goodman, Thor Kuusivuori-Robinson, Christina Coughlan, Yaritza Delgado-Deida, Joseph C. Onyiah, Janos Zempleni, Arianne L. Theiss   +7 more
doaj   +2 more sources

The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]

Journal of Translational Medicine
Background ERAP2 is an aminopeptidase involved in antigen processing and presentation, and harbor genetic variants linked to several inflammatory diseases such as Inflammatory Bowel Disease (IBD).
Siri Sæterstad, Ann Elisabeth Østvik, Marianne Doré Hansen, Torunn Bruland, Atle van Beelen Granlund   +4 more
doaj   +2 more sources

Oxidized Low-Density Lipoprotein Induces Reactive Oxygen Species-Dependent Proliferation of Intestinal Epithelial Cells [PDF]

Pharmaceuticals
Background/Objectives: Oxidized low-density lipoprotein (ox-LDL) is a proinflammatory particle associated with various diseases and affects cell proliferation and viability in multiple cell types.
Eddy E. Gonzalez-Horta, Juan F. Burgueno, María J. Leiva, Carla Villavicencio, Fernando I. Kawaguchi, Hajar Hazime, Fátima Reyes, Viana Manrique-Suárez, Natalie C. Parra, Maria T. Abreu, Jorge R. Toledo   +10 more
doaj   +2 more sources

Non pathological sweat test, pancreatic insufficiency and Cystic Fibrosis: an unusual case in a child with F508del-duplication of exons 1–3 CFTR genotype [PDF]

BMC Pediatrics
While Cystic Fibrosis is characterized by a high phenotypic variability, a correlation is reported between the pancreatic status and the CFTR genotype.
Vito Terlizzi, Cristina Fevola, Alice Castaldo, Selene Del Vespa, Daniela Dolce, Luca Scarallo, Karina Kleinfelder, Paola Melotti, Claudio Sorio, Giovanni Taccetti, Paolo Lionetti   +10 more
doaj   +2 more sources

Measurement of Real-Time Serotonin Dynamics from Human-Derived Gut Organoids. [PDF]

Anal Chem
The importance of the gut in regulating the brain-body immune axis is becoming increasingly evident. Interestingly, the brain and gut share many common signaling molecules, with serotonin being one of the most notable.
Bohl B, Lei Y, Bewick GA, Hashemi P.
europepmc   +3 more sources