Cancer Medicine, 2020 Molecular‐targeted therapies have demonstrated disappointing results against most advanced solid cancers. This may largey be attributed to irrational drug use against unselected cancers.
Ashokkumar Dilly +4 more
doaj +1 more source
Concise Review: The Potential Use of Intestinal Stem Cells to Treat Patients With Intestinal Failure. [PDF]
, 2016 : Intestinal failure is a rare life-threatening condition that results in the inability to maintain normal growth and hydration status by enteral nutrition alone.
Dunn, James CY +3 more
core +1 more source
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology [PDF]
Journal of Biological Chemistry, 2016 Identification of Lgr5 as the intestinal stem cell marker as well as the growth factors necessary to replicate adult intestinal stem cell division has led to the establishment of the methods to generate "indefinite" ex vivo primary intestinal epithelial cultures, termed "mini-intestines." Primary cultures developed from isolated intestinal crypts or ...
Zachos, NC +7 more
openaire +2 more sources
Mechanisms of Intestinal Epithelial Barrier Dysfunction by Adherent-Invasive Escherichia coli. [PDF]
, 2016 Pathobiont expansion, such as that of adherent-invasive Escherichia coli (AIEC), is an emerging factor associated with inflammatory bowel disease. The intestinal epithelial barrier is the first line of defense against these pathogens.
McCole, Declan F, Shawki, Ali
core +1 more source
An in vitro chronic damage model impairs inflammatory and regenerative responses in human colonoid monolayers [PDF]
Cell Reports, 2022 Acute damage to the intestinal epithelium can be repaired via de-differentiation of mature intestinal epithelial cells (IECs) to a stem-like state, but there is a lack of knowledge on how intestinal stem cells function after chronic injury, such as in inflammatory bowel disease (IBD).
William D. Rees +8 more
openaire +2 more sources
Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis
Gut Microbes, 2021 Amyotrophic Lateral Sclerosis is a neuromuscular disease characterized by the progressive death of motor neurons and muscle atrophy. The gastrointestinal symptoms in ALS patients were largely ignored or underestimated.
Yongguo Zhang +4 more
doaj +1 more source
Organoids, organs-on-chips and other systems, and microbiota [PDF]
, 2017 The human gut microbiome is considered an organ in its entirety and has been the subject of extensive research due to its role in physiology, metabolism, digestion, and immune regulation.
Evans, Samantha +2 more
core +2 more sources
Human iPSC Colonoid Function is Improved by Exposure to Fecal Fermentates
The FASEB Journal, 2021 The host‐microbe interaction is critical for intestinal homeostasis. By‐products from microbial metabolism of unabsorbed dietary components have been studied increasingly as potential contributors to health and disease. In vitro fermentation systems provide a way to simulate microbial activity and by‐product production of the colon using human fecal ...
Sarah Pearce +3 more
openaire +1 more source
Epithelial WNT2B and Desert Hedgehog are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury [PDF]
SSRN Electronic Journal, 2020 Intestinal regeneration and crypt hyperplasia after radiation or pathogen injury relies on Wnt signaling to stimulate stem cell proliferation. Mesenchymal Wnts are essential for homeostasis and regeneration in mice, but the role of epithelial Wnts remains largely uncharacterized. Using the enterohemorrhagic E.
Julie G. In +10 more
openaire +3 more sources
Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust. [PDF]
Environ Health PerspectUranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been ...
Atanga R +7 more
europepmc +3 more sources