Results 81 to 90 of about 1,557 (180)
Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus [PDF]
, 2021 Enteroviruses, such as EV-A71 and CVA16, mainly infect the human gastrointestinal tract. Human coronaviruses, including SARS-CoV and SARS-CoV-2, have been variably associated with gastrointestinal symptoms.
Cai, Jian Piao +13 more
core +1 more source
Using a human colonoid-derived monolayer to study bacteriophage translocation
Gut MicrobesBacteriophages (phages) are estimated to be the most abundant microorganisms on Earth. Their presence in human blood suggests that they can translocate from non-sterile sites such as the gastrointestinal tract where they are concentrated. To examine phage translocation ex vivo, we adapted a primary colonoid monolayer model possessing cell diversity and
Huu Thanh Le +8 more
openaire +4 more sources
Generation of Intestinal and Colonic Organoids Derived From Human Pluripotent Stem Cells
Biology of the Cell, Volume 117, Issue 12, December 2025.Human pluripotent stem cells can be guided through a stepwise differentiation process to produce self‐organizing intestinal and colonic organoids. The resulting organoids recapitulate fetal‐stage epithelial and mesenchymal organization, offering a powerful model to explore human gastrointestinal development and its disorders.
Lola Bonneau +7 more
wiley +1 more source
Establishment of patient-derived enteroids/colonoids from endoscopic biopsies v1
, 2023 This protocol describes the full procedure of generating an enteroid or colonoid culture from endoscopic biopsy (either freshly procured or recovered from cryopreservation), was developed for human tissue, but works equally well for murine tissue fragments.
openaire +1 more source
Cancer Medicine, Volume 14, Issue 13, July 2025.Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana +4 more
wiley +1 more source
Vitamin D receptor protects against dysbiosis and tumorigenesis via the JAK/STAT pathway in intestine [PDF]
, 2020 BACKGROUND & AIMS: Vitamin D exerts regulatory roles via vitamin D receptor (VDR) in mucosal immunity, host defense, and inflammation involving host factors and microbiome.
Chatterjee, Ishita +6 more
core +2 more sources
Molecular Nutrition &Food Research, Volume 69, Issue 14, July 2025.Identifying health‐promoting molecules such as bioactive peptides in complex food mixtures is a major challenge. In this study, we investigated proteins and protein hydrolysates from four quinoa varieties to evaluate their potential anticancer effects on colorectal adenocarcinoma cells.
Alessandro Zaccarelli +6 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background & Aims: The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage.
Ansen H.P. Burr +19 more
doaj +1 more source
The FASEB Journal, Volume 39, Issue 11, 15 June 2025.The complexity of indole‐3‐acetic acid's (IAA's) role in human health and disease. IAA is a multifaceted compound with significant consequences for several physiological and pathological processes. ABSTRACT Indole‐3‐acetic acid (IAA) is recognized as a common plant growth hormone.
Nargis Shaheen +4 more
wiley +1 more source
Molecular biosignatures and gut-barrier alterations in inflammatory bowel diseases [PDF]
, 2022 Inflammatory bowel diseases (IBD) are chronic immune-mediated disorders affecting the gastrointestinal tract. The multifactorial pathophysiology of IBD is commonly explained as an abnormal interplay between genetic, immune, environmental and microbial ...
Moraes Holst, Luiza
core +1 more source