Results 1 to 10 of about 1,067,070 (316)

The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]

, 2018
Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
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Predicting prognosis according to preoperative chemotherapy response in patients with locally advanced lower rectal cancer

BMC Cancer, 2019
Background Neoadjuvant chemoradiotherapy is regarded as the standard of treatment for locally advanced lower rectal cancer, although some of these cases are systemic, and distant control may be inadequate.
Takuya Shiraishi, Takeshi Sasaki, Koji Ikeda, Yuichiro Tsukada, Yuji Nishizawa, Masaaki Ito   +5 more
doaj   +1 more source

Juvenile polyposis syndrome might be misdiagnosed as familial adenomatous polyposis: a case report and literature review

BMC Gastroenterology, 2020
Background Juvenile polyposis syndrome (JPS) is a rare disorder characterized by the presence of multiple juvenile polyps in the gastrointestinal tract, and germline mutations in SMAD4 or BMPR1A.
Xian Hua Gao, Juan Li, Zi Ye Zhao, Xiao Dong Xu, Yi Qi Du, Hong Li Yan, Lian Jie Liu, Chen Guang Bai, Wei Zhang   +8 more
doaj   +1 more source

Deep-Learning for Classification of Colorectal Polyps on Whole-Slide Images

, 2017
Histopathological characterization of colorectal polyps is an important principle for determining the risk of colorectal cancer and future rates of surveillance for patients. This characterization is time-intensive, requires years of specialized training,
Hassanpour, Saeed, Korbar, Bruno, Miraflor, Allen P., Nicka, Katherine M., Olofson, Andrea M., Suriawinata, Arief A., Suriawinata, Matthew A., Torresani, Lorenzo   +7 more
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Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer

Clinical and Translational Medicine, 2020
Background Accumulating evidence demonstrated immune/inflammation-related implications of basophils in affecting tissue microenvironment that surrounded a tumor, and this study aimed to elucidate the clinical value of serum basophil count level.
Qi Liu, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li   +4 more
doaj   +1 more source

RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. [PDF]

, 2013
ObjectiveTo determine the impact of RAS mutation status on survival and patterns of recurrence in patients undergoing curative resection of colorectal liver metastases (CLM) after preoperative modern chemotherapy.BackgroundRAS mutation has been reported ...
Aloia, Thomas A, Andreou, Andreas, Chen, Su S, Curley, Steven A, Kopetz, Scott E, Maru, Dipen M, Shindoh, Junichi, Vauthey, Jean-Nicolas, Zimmitti, Giuseppe   +8 more
core   +1 more source

Preoperative T staging using CT colonography with multiplanar reconstruction for very low rectal cancer

BMC Cancer, 2017
Background Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy.
Dai Shida, Gen Iinuma, Akira Komono, Hiroki Ochiai, Shunsuke Tsukamoto, Mototaka Miyake, Yukihide Kanemitsu   +6 more
doaj   +1 more source

Hepatic metastases from colorectal carcinoma [PDF]

, 1993
Colorectal carcinoma is one of the increasing afflictions and is the 2nd commonest cause of death from cancer in the Western world. It accounts from 14% of cancer deaths in men and 16% of deaths in women.
LaFerla, Godfrey
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Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. [PDF]

, 2013
A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this
Ash, Colleen, Beck, Timothy, Bielecki, Ryszard, Boutros, Paul C, Chan-Seng-Yue, Michelle, Chong, Taryne, D'Souza, David JA, De Borja, Richard, Dick, John E, Gallinger, Steven, Gryfe, Robert, Hodgson, Lyndsey, Hudson, Thomas J, Kozak, Krystian, Kwan, Jennifer YY, Lee, Shawna, Lemire, Mathieu, McPherson, John D, Peltekova, Vanya D, Pollett, Aaron, Qazi, Aamer M, Rangrej, Jagadish, Rogers, Marianne, Stein, Lincoln D, Timms, Lee, Trinh, Quang M, Volar, Milica, Wang, Jianxin, Wang, Mike, Zaidi, Syed HE, Zandi, Sasan, Zanke, Brent W   +31 more
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An electronic family health history tool to identify and manage patients at increased risk for colorectal cancer: protocol for a randomized controlled trial. [PDF]

, 2019
BackgroundColorectal cancer is the fourth most commonly diagnosed cancer in the United States. Approximately 3-10% of the population has an increased risk for colorectal cancer due to family history and warrants more frequent or intensive screening. Yet,
Coffman, Cynthia J, Datta, Santanu K, Fisher, Deborah A, Goldstein, Karen M, Grubber, Janet M, Hauser, Elizabeth R, Nelson, Richard E, Orlando, Lori A, Provenzale, Dawn, Rakhra-Burris, Tejinder, Scheuner, Maren T, Sperber, Nina, Strawbridge, Elizabeth, Voils, Corrine I, Wang, Virginia, Wu, R Ryanne   +15 more
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