Results 141 to 150 of about 334,109 (235)

4‐(5‐Chloro‐3‐(3,4,5‐trimethoxybenzoyl)‐1H‐indol‐1‐yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β‐Catenin Signaling Pathway, and P‐Glycoprotein

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Polypharmacology is expected to produce higher therapeutic efficacy and lower cytotoxic and side effects. Compound 15 exhibited strong inhibition of the human carbonic anhydrase isoforms IX and XII and selectivity toward the adverse isoforms I and II.
Michela Puxeddu, Rosa Bordone, Claudia Colla, Gabriele Rotili, Antonio Coluccia, Pietro Sciò, Petra Cuřínová, Alessio Nocentini, Claudiu T. Supuran, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Lucia Jimenez, Wolfgang Link, Chiara Bigogno, Giulio Dondio, Martina Barba, Gianluca Canettieri, Romano Silvestri, Giuseppe La Regina   +21 more
wiley   +1 more source

KLF2 inhibits cell growth via regulating HIF-1α/Notch-1 signal pathway in human colorectal cancer HCT116 cells.

Oncology Report, 2017
Haigang Wang, B. Cao, Li-xian Zhang, N. Song, Hui Li, Wen-zeng Zhao, Yan-Shu Li, Shun-mao Ma, Dong-Jian Yin   +8 more
semanticscholar   +1 more source

The response of chemoresistant human colorectal cancer cells HCT116 to cytotoxic treatment

, 2019
Nepaisant pažangos kolorektalinio vėžio (KRV) diagnostikoje bei gydyme, beveik pusė susirgusiųjų neišgyvena. Viena iš to priežasčių – įgimtas arba gydymo metu įgytas vėžio ląstelių atsparumas chemoterapiniams vaistams. Šiame darbe vertinome autofagijos, Wnt/β-katenino ir Notch1 signalinių kelių reikšmę žmogaus kolorektalinės karcinomos ląstelių HCT116 ...
openaire   +1 more source

Differential Cellular Responses to Prolonged LDR-IR in MLH1-Proficient and MLH1-Deficient Colorectal Cancer HCT116 Cells

Clinical Cancer Research, 2009
T. Yan, Yuji Seo, T. Kinsella
semanticscholar   +1 more source

Picropodophyllin, an IGF‑1 receptor inhibitor, enhances oxaliplatin efficacy in chemoresistant colorectal cancer HCT116 cells by reducing metastatic potential. [PDF]

Oncol Lett
Kayacik N, Kurter H, Sever T, Basbinar Y, Calibasi-Kocal G.   +4 more
europepmc   +1 more source

Investigation of the Cytotoxic and Antiproliferative Effects of Liposomal Daunorubicin on Human Colorectal Cancer (HCT116) Cell Line. [PDF]

Iran J Pharm Res
Alaa Hadi-Al-Ward N, Ebrahimi M, Zare Karizi S.   +2 more
europepmc   +1 more source

Novel antagonist APG-115 targets MDM2-p53 to induce p53-mediated apoptosis and radiosensitization in colorectal cancer. [PDF]

Clin Exp Med
Yi H, Han Y, Wang X, Li Q, Xiong L, Li S.   +5 more
europepmc   +1 more source

Investigating the effects of platelets, platelet releasate and aspirin on colorectal cancer cell proliferation, migration and invasion. [PDF]

Med Oncol
Capraro D, Connor DE, Joseph JE.
europepmc   +1 more source

SMYD3 synergises with RACK1 to promote colorectal cancer lung metastasis by recruiting SMAD3. [PDF]

Cell Commun Signal
Bai X, Han D, Chen J, Sheng S, Feng H, Wang H, Xu K, Huang Y, Huang M, Chu X, Chen Y, Lei Z.   +11 more
europepmc   +1 more source

Ginsenoside Rg5 inhibits colorectal cancer, at least partially by blocking the lysosomal degradation of colorectal cancer cells. [PDF]

Sci Rep
Guo X, Sun R, Su Y, Qin Q, Liu Y, Qiu C.
europepmc   +1 more source