Results 201 to 210 of about 4,157,974 (295)

Laparoscopic versus open minor liver resections of colorectal cancer liver metastases in a state at war: A prospective cohort study. [PDF]

Surg Open Sci
Burlaka A, Zemskov S, Rozhkova V, Zvirych V, Dupyk M, Beznosenko A, Bezverkhnyi V, Skyba V.   +7 more
europepmc   +1 more source

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf, Melanie Rinas, Benjamin Engelhardt, Rabih Saab, Cen Guo, Cristiano Ferlini, Kevin J. Freise, Rajeev M. Menon, Akshanth R. Polepally   +8 more
wiley   +1 more source

High-intensity focused ultrasound in the multimodal treatment of colorectal cancer liver metastases: A case report. [PDF]

Oncol Lett
Yang Y, Zhang H, Shen Y, Yang F, Zhao D, Lin Y, Huang G.   +6 more
europepmc   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Correction: <i>Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases</i>. [PDF]

Gut
europepmc   +1 more source

Tight junction-high and CDH17-positive cell population is the source of colorectal cancer liver metastases. [PDF]

Nat Commun
Alvarez-Villanueva D, Maqueda M, Harti D, Canton E, Andrades E, Bertran J, Martínez-Iniesta M, Solé L, García-Hernández V, Montoto Á, Lobo-Jarne T, Alonso-Marañón J, Herrero-Molinero P, Larrubia-Loring M, Tramuns A, Wynne K, Bera I, Matallanas D, Villanueva A, Bigas A, Iglesias M, Espinosa L.   +21 more
europepmc   +1 more source

Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm

Gut Medicine, EarlyView.
ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang, Narisu Hu, Shuang Pan, Sohaib Shujaat, Zhihui Tang, Hongyang Ma   +5 more
wiley   +1 more source

Higher frequency of subclonal anti-EGFR resistance mutations in post-treatment samples from patients with colorectal cancer liver metastases following anti-EGFR-based conversion chemotherapy. [PDF]

PLoS One
Steup C, Mondorf A, Wild P, Pession U, Bechstein WO, Michael FA, Winter M, Bein J, Zeuzem S, Trojan J, Koch C.   +10 more
europepmc   +1 more source

Pretreatment Cachexia Index Is Associated With Severe Treatment Toxicity and Overall Survival in HPV‐Negative Head and Neck Squamous Cell Carcinoma

Head &Neck, EarlyView.
ABSTRACT Introduction Cancer cachexia is characterized by skeletal muscle loss, poor nutrition, and systemic inflammation and is common in head and neck cancer. We evaluated whether the Cachexia Index (CXI) predicts treatment toxicity and survival in HPV‐negative HNSCC.
Gianluca Savoia, Michael P. Hier, Nader Sadeghi, Alex Mlynarek, Keith Richardson, Sabrina Daniela Silva Wurzba, Christina Tsien, George Shenouda, Khalil Sultanem, Nathaniel Bouganim, Khashayar Esfahani, Marco A. Mascarella   +11 more
wiley   +1 more source

The prognostic value of immunoscore in colorectal cancer liver metastases: a meta-analysis reveals the superiority of metastatic over primary tumor profiling. [PDF]

BMC Cancer
Hou S, Wu X, Zhu H, Yao Y, Gao Z, Ye Y, Shen K.   +6 more
europepmc   +1 more source