Results 211 to 220 of about 4,157,974 (295)

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue   +6 more
wiley   +1 more source

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Spot‐based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single‐cell RNA sequencing (scRNA‐seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular heterogeneity within spots, requiring computational deconvolution to ...
Stefan Altendorfer   +2 more
wiley   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co-opting tumors in colorectal cancer liver metastases. [PDF]

open access: yesFEBS J
Gantz A   +9 more
europepmc   +1 more source

Physical Activity and Risk of Liver Cancer: A Competing Risk Analysis

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Physical activity is associated with lower risk of liver cancer, but obtaining an unbiased estimate of the causal effect is challenging due to the competing risk of death due to any other cause. We performed a causal competing risk analysis to estimate the total effect of physical activity on risk of liver cancer in the presence of competing ...
Frances E. M. Albers   +9 more
wiley   +1 more source

Activity of Low Dose Nivolumab in Patients With Advanced Squamous Cell Carcinomas and Other Cancers

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors such as anti–PD‐1 antibodies are essential in cancer therapy. Emerging data suggest that lower doses may be effective and more economical, though further evidence is needed. We conducted a retrospective study at Centre Léon Bérard to assess the efficacy and safety of low‐dose nivolumab (20 mg every 3 weeks) in ...
Thibault Gauduchon   +16 more
wiley   +1 more source

Improved Prediction of Colon Cancer Recurrence Using the ColoNode mRNA Test: A 5‐Year Survival Analysis

open access: yesInternational Journal of Cancer, EarlyView.
ABSTRACT Twenty‐five percent of colon cancer patients having curative surgery will recur. Most of them will die from distant metastasis partly due to shortcomings of routine histopathological analysis, that is, undetected tumor cells in the regional lymph node field.
Basel Sitohy   +20 more
wiley   +1 more source

Delta-Radiomics Biomarker in Colorectal Cancer Liver Metastases Treated with Cetuximab Plus Avelumab (CAVE Trial). [PDF]

open access: yesDiagnostics (Basel)
Nardone V   +14 more
europepmc   +1 more source

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