Results 51 to 60 of about 4,157,974 (295)

The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE [PDF]

, 2023
Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases ...
Verhoef C., Lesurtel M., Gurses B., Jonas E., Andersson B., Buchwald P., Kartalis N., Gruenberger T., Dasari B. V. M., Jamdar S., Stattner S., Adam R., Ramia-Angel J. M., Devar J., Pellino G., Stassen L., Spiers H. V. M., Zmora O., Tejpar S., Soreide K., Boudjema K., Jarnagin W., Vauthey J. -N., Gruenberger B., Aldrighetti L., Kokudo N., Wigmore S. J., Meijerink M., Jones R., Mullamitha S., Serrablo A., Balakrishnan A., Cipriani F., Valdivieso A., Siriwardena A. K., Malik H. Z., Frampton A. E., Hilal M. A., Fretland A. A., E-AHPBA/ESSO/ESCP/ESGAR/CIRSE 2022 Consensus on colorectal cancer with synchronous liver metastases, Wasserberg N.   +40 more
core   +1 more source

Liver Metastases in Colorectal Cancer

Journal of the Korean Society of Coloproctology, 2009
Liver metastases in colorectal cancer are a frequent and lethal complication. Although hepatic resection is an effective treatment for patients with liver metastases in colorectal cancer, only 10-20% of the patients with liver metastases in colorectal cancer are indicated on hepatic resection. However, over the past several decades, liver resection has
Jae Im Lee, Seong Taek Oh
openaire   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Supplementary Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

, 2022
Supplementary Data from Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic ...
Rik G.H. Lindeboom, Jacco van Rheenen (412916), Koen C. Oost, Niek A. Peters, Hugo J.G. Snippert, Mirjam C. van der Net (14955357), Rik G.H. Lindeboom (14955351), Lisa van Voorthuijsen, Martijn Gloerich, Onno Kranenburg (14955372), Jacco van Rheenen, Maria C. Heinz, Mirjam C. van der Net, Prisca Liberali (14955366), Joris H. Hageman, Inne H.M. Borel Rinkes, Michiel Vermeulen (131210), Inne H.M. Borel Rinkes (14917638), Koen C. Oost (14955348), Ingrid Verlaan-Klink, Hugo J.G. Snippert (14955375), Maria C. Heinz (14955342), Ingrid Verlaan-Klink (4167301), Joris H. Hageman (14955363), Michiel Vermeulen, Lisa van Voorthuijsen (14955354), Arianna Fumagalli, Arianna Fumagalli (841965), Gustavo de Medeiros, Onno Kranenburg, Niek A. Peters (14955345), Prisca Liberali, Gustavo de Medeiros (14955360), Martijn Gloerich (14955369)   +33 more
core   +3 more sources

Case report: hepatic arterial infusion chemotherapy combined with sintilimab and lenvatinib for conversion therapy of colorectal cancer liver metastases

Frontiers in Immunology, 2023
BackgroundLiver metastasis is one of the most common causes of death in patients with colorectal cancer. Therefore, improving the treatment effect of liver metastatic carcinoma of colorectal cancer is also one of the effective ways to improve the ...
Kai Peng, Yuhua Li, Hao Su, Chenlu Lan, Zaida Huang, Yongguang Wei, Xiwen Liao, Xiwen Liao, Minhao Peng, Tao Peng, Tao Peng, Tao Peng, Guangzhi Zhu, Guangzhi Zhu   +13 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Molecular imaging using positron emission tomography in gastrointestinal malignancy [PDF]

, 2010
Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effective second-line treatment with cetuximab and bevacizumab in a patient with hepatic metastases of colorectal cancer and hyperbilirubinemia [PDF]

, 2007
Background: Irinotecan-based second-line chemotherapy of metastatic colorectal cancer (CRC) is effective, it might, however, be contraindicated in cases of severe liver dysfunction due to advanced liver metastases.
Moosmann, Nicolas, Schulz, Christoph, Laessig, Dorit, Michaely, Henrik Jakob, Heinemann, Volker   +4 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source