Results 11 to 20 of about 9,868 (158)
High Grade Dysplastic Rectal Adenoma in a Young Patient With Café-Au-Lait Spots: A Case Report. [PDF]
Clin Case RepABSTRACT Colorectal cancer screening guidelines typically focus on familial history and age‐related risk factors, yet Café‐au‐lait macules could serve as early indicators for tailored surveillance protocols. This case underscores the importance of considering extracolonic manifestations in young patients presenting with colorectal symptoms.
Hamdan A +4 more
europepmc +2 more sources
Hereditary Nonpolyposis Colon Cancer (Lynch Syndrome): An Emerging Public Health Concern. [PDF]
Health Sci RepABSTRACT Background Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes that confer increased lifetime risks for colorectal, endometrial, and other cancers.
Mohiuddin M.
europepmc +2 more sources
A rare case of colonic adenocarcinoma in a pediatric patient. [PDF]
JPGN RepAbstract Lynch syndrome (LS) is an autosomal dominant condition caused by a loss of function in the deoxyribonucleic acid mismatch repair system. This case report presents a 17‐year‐old male with abdominal pain, weight loss, and anemia who was diagnosed with LS‐associated adenocarcinoma of the colon in the setting of a mutS homolog 6 genetic mutation ...
Kaba C +4 more
europepmc +2 more sources
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Frontiers in Medicine, 2022 BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li +7 more
doaj +1 more source
European Medical Journal, 2019 Primary cardiac tumours are exceedingly unusual and aggressive; they often develop in younger patients and present with advanced disease. The rarity and heterogeneity of primary cardiac tumours challenge the standardisation of therapeutic guidelines. Undifferentiated primary cardiac spindle cell sarcomas, a distinct subset of primary cardiac sarcomas ...
Emily Bryer, Lee Hartner
openaire +2 more sources
Do hereditary syndrome-related gynecologic cancers have any specific features? [PDF]
, 2015 Hereditary syndromes are responsible for 10 % of gynaecologic cancers, among which hereditary breastovarian cancer and hereditary non-polyposis colon cancer syndromes, known as HBOC and Lynch syndromes respectively, present the highest relative risk.
Cunha, Teresa Margarida, Neto, Nelson
core +1 more source
Investigating the Link between Lynch Syndrome and Breast Cancer
European Journal of Breast Health, 2020 Objective:Lynch syndrome is an inherited genetic disorder associated with a predisposition to early-onset colorectal and endometrial cancers, but breast cancer risk in these patients is debated. The aim of this study is to evaluate breast cancer rates in
Megan Sheehan +7 more
doaj +1 more source
Pancreatic Cancer in Lynch Syndrome Patients [PDF]
, 2017 Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors.
Bujanda Fernández de Pierola, Luis +1 more
core +3 more sources
Molecular diagnosis of hereditary nonpolyposis colorectal cancer (Lynch syndrome)
Revista de la Facultad de Medicina, 2016 Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer.
David Serrano, Clara Eugenia Arteaga
doaj +1 more source