Results 51 to 60 of about 9,868 (158)

Deficient mismatch repair: Read all about it (Review) [PDF]

, 2015
Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers.
Adackapara, Alvino, Alvino, An, An, André, Bao, Bapat, Beamer, Beghelli, Begum, Bellcross, Bertagnolli, Birindelli, Boland, Bonadona, Bouzourene, Braun, Capper, Capper, Castiglia, Catasús, Chew, Chew, Cicek, Cohn, Colomba, Cravo, Crucianelli, Cunningham, Cunningham, Des Guetz, Diaz-Padilla, Elsaleh, Elsaleh, Engel, Ercoli, Fadhil, Falchetti, Fang, Fearon, Gazzoli, Genuardi, Graham, Graham, Gras, Guastadisegni, Halford, Hitchins, Hong, Hussein, Hussein, Hutchins, Huth, Ihle, Jasperson, Jass, Jensen, Kane, Kato, Kim, Kim, Kim, Kloor, Koopman, Korabiowska, Ladabaum, Lee, Ligtenberg, Liu, Loes, Loughrey, Lynch, Malesci, Marcelis, Matthews, McGivern, Mensenkamp, Murphy, Musulen, Mvundura, Müller, Nelson, Nilbert, Oki, Pal, Palmieri, Palmieri, Perez, Peris, Pineda, Plazzer, Poynter, Pritchard, Quinn, Resnick, Ribic, Richetta, Richetta, Ringelhan, Rodriguez-Bigas, Roth, Ruiz, Sargent, Scartozzi, Schneider, Schofield, Schofield, Sie, Sinicrope, Snowsill, Snowsill, SUSAN RICHMAN, Talwalkar, Terada, Thibodeau, Tikidzhieva, Tomiak, Tomlinson, Tomlinson, Umar, Vasen, Vasen, Venderbosch, Wang, Ward, Watson, Xiao, Xicola, Yan, Zaanan, Zhai   +131 more
core   +1 more source

Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin

International Journal of Cancer, Volume 157, Issue 7, Page 1481-1495, 1 October 2025.
What's New? Integrins are critical mediators of cell adhesion and migration and have been implicated in cancer progression. Here, the authors show that endothelial cells in target organs of colorectal cancer metastasis express fibronectin, and that colorectal cancer tumour cells can bind fibronectin through integrin β6. This interaction is resistant to
Chiara Van Passen, Julia Krug, Luisa Weiß, Mariam Mohamed Abdou, Philipp Tripal, Benjamin Schmid, René Krüger, Yanmin Lyu, Bisan Abdalfatah Zohud, Katja Petter, Carol Geppert, Susanne Merkel, Barbara Bärthlein, Philipp Busenhart, Michael Scharl, Elisabeth Naschberger, Michael Stürzl   +16 more
wiley   +1 more source

Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma [PDF]

, 2017
Postreplicative mismatch repair safeguards the stability of our genome. The defects in its functioning will give rise to microsatellite instability. In this study, 50 meningiomas were investigated for microsatellite instability. Two major mismatch repair
Bukovac, Anja, Hrašćan, Reno, Kafka, Anja, Pećina-Šlaus, Nives, Tomas, Davor, Vladušić, Tomislav   +5 more
core   +1 more source

Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average‐Risk Women

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Objective The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case–control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi‐center Colorectal Neoplasia Screening with ...
Doratha A. Byrd, Maria F. Gomez, Stephanie R. Hogue, Jessica R. Burns, Nate Smith, Joshua Sampson, Erikka Loftfield, Patricia G. Wolf, Yunhu Wan, Andrew Warner, Belynda Hicks, Casey Dagnall, Kristine Jones, Youngchul Kim, Jin Xu, Jianxin Shi, Rashmi Sinha, Emily Vogtmann   +17 more
wiley   +1 more source

Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling strategies as well as care planning and informs the development of patient‐reported outcome measures
M. Sztankay, S. Wheelwright, V. Vassiliou, E. M. A. Bleiker, B. Rahman, B. Holzner, A. Yener, V. Engele, A. S. Oberguggenberger, EORTC Quality of Life Group   +9 more
wiley   +1 more source

CGPD: Cancer Genetics and Proteomics Database - A Dataset for Computational Analysis and Online Cancer Diagnostic Centre [PDF]

, 2014
Cancer Genetics and Proteomics Database (CGPD) is a repository for genetics and proteomics data of those Homo sapiens genes which are involved in Cancer. These genes are categorized in the database on the basis of cancer type.
Attia Iram, Muhammad Rizwan Riaz
core  

Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin. [PDF]

, 2006
Background: K-ras mutations are a key step in colorectal cancer progression. Such mutations have been widely studied in case series from Western countries but there are few data on the rate and spectrum of mutations in tumors from countries where the ...
AGNESE, Valentina, BAZAN, Viviana, BISHEHSARI F, CAMA A, CATALANO T, COLUCCI G, DE LELLIS L, ESPOSITO DL, HORMAZDI, M, IACOBELLI S, MAHDAVINIA M, MALEKZADEH R, MARIANI COSTANTINI R., PIANTELLI M, RAKHSHANI N, RUSSO, Antonio, SEMERARO D, SOTOUDEH, M, VERGINELLI F   +18 more
core   +1 more source

Germline Cancer Susceptibility Variants in Patients With Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 38, Issue 5, September 2025.
Germline exome sequencing of 106 Finnish patients with UM, considered at higher risk for genetic cancer predisposition, identified pathogenic or likely pathogenic variants associated with varying risk of malignancies in 16 patients (15%). Six patients (6%) carried multiple variants and had a median diagnosis age of 51, compared to 60 in the full cohort
Pauliina E. Repo, Eveliina Jakkula, Juho Hiltunen, Heidi Putkuri, Aleksandra Staskiewicz‐Tuikkanen, Reetta‐Stiina Järvinen, Martin Täll, Virpi Raivio, Rana'a T. Al‐Jamal, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source