Results 51 to 60 of about 3,326,305 (294)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Color Stability of Dental Composites after Immersion in Beverages and Performed Whitening Procedures

Acta Stomatologica Croatica, 2022
Objectives: The study aimed to compare the color stability of two different light-cured composites after immersion in three liquids and the effectiveness of 16% carbamide peroxide (CP) in removing the discoloration.
Samra Korać, Muhamed Ajanović, Aida Džanković, Alma Konjhodžić, Lajla Hasić-Branković, Alma Gavranović-Glamoč, Irmina Tahmiščija   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In search of the rainbow: Colored inks in surgical pathology

Indian Journal of Pathology and Microbiology, 2012
Introduction: Although surgical pathologists are aware of the multiple advantages that coloured inks contribute to surgical pathology practice, these coloured inks are not available in India and importing them is not a viable proposition.
Chandralekha Tampi
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

A curious case of vanishing pigmented spots resembling lentigines

Indian Journal of Dermatopathology and Diagnostic Dermatology, 2019
Exogenous pigmentation due to arthropods or coloring agents/dyes may be mistaken for melanocytic lesions. Dermoscopy is a useful tool for the evaluation of pigmented lesions.
Meenakshi Batrani, Arshdeep, Asha Kubba, M Ramam   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation of the Antibacterial Activity of Annatto Dye on Some Pathogenic Bacteria

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2014
Background and Objectives:Today, disadvantages of antibiotics and synthetic preservatives have been identified, and researchers are seeking natural and safe alternatives.
Mahmoud Yolmeh, Mohammad Bagher Habibi Naja, Reza Farhoosh, Fereshteh Hosseini   +3 more
doaj  

Chemical-induced occupational asthma: A case series

Indian Journal of Allergy Asthma and Immunology
Exposure to a variety of chemicals is known to have adverse consequences, occupational asthma being one of them. Isocyanate exposure has been found to be associated with airways obstructive abnormalities, but Indian data in this context are scarce ...
Rakesh Kumar Singh, Parul Mrigpuri, Balakrishnan Menon, Mridul Sarma   +3 more
doaj   +1 more source

Surface properties of multilayered, acrylic resin artificial teeth after immersion in staining beverages

Journal of Applied Oral Science, 2015
Objective To evaluate the effect of staining beverages (coffee, orange juice, and red wine) on the Vickers hardness and surface roughness of the base (BL) and enamel (EL) layers of improved artificial teeth (Vivodent and Trilux).Material and Methods ...
Karin Hermana NEPPELENBROEK, Eduardo KUROISHI, Juliana HOTTA, Vinicius Rizzo MARQUES, Eduardo Buozi MOFFA, Simone SOARES, Vanessa Migliorini URBAN   +6 more
doaj   +1 more source