Results 101 to 110 of about 303 (129)

<i>Angelicae Pubescentis</i> Radix Remitted Intestine Damage in Mice Induced by <i>Escherichia coli</i> via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut Microbiota. [PDF]

Vet Sci
Deng K, Xu C, He Q, Safdar M, Nazar M, Li X, Li K.   +6 more
europepmc   +1 more source

Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke. [PDF]

J Pharm Anal
Jin X, Liu S, Chen S, Han R, Sun X, Wei M, Chang Y, Li L, Zhang H.   +8 more
europepmc   +1 more source

Columbianadin ameliorates rheumatoid arthritis by attenuating synoviocyte hyperplasia through targeted vimentin to inhibit the VAV2/Rac-1 signaling pathway [PDF]

Journal of Advanced Research
Rheumatoid arthritis (RA) is an autoimmune disease pathologically characterized by synovial inflammation. The abnormal activation of synoviocytes seems to accompany the progression of RA. The role and exact molecular mechanism in RA of columbianadin (CBN) which is a natural coumarin is still unclear.The present research aimed to investigate the effect ...
Han Y, Liu C, Chen S, Sun H, Jia Z, Shi J, Wang L, Du K, Chang Y.   +8 more
exaly   +4 more sources

Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro

Phytochemistry, 2012
Columbianadin (CBN, 1), 1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethyl-[(2Z)-2-methyl-2-butenoic acid jester is a coumarin-type compound and one of the main bioactive constituents of the underground part of Angelica pubescens ...
Yan-Fang Yang
exaly   +4 more sources

Vibrational spectroscopic studies on the natural product, columbianadin

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2003
NIR-FT Raman and FT-IR spectra of columbianadin, extracted from seeds and roots of Heracleum candolleaum, were recorded and analyzed. The vibrational frequencies of the compound have been computed using semi-empirical AM1 method and compared with experimental values.
Abraham, Jose P, George, V., Jayakumar, V.S., Joe, I.H., Nielsen, Ole Faurskov   +4 more
exaly   +4 more sources

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Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-α induced dendritic cells

Journal of Ethnopharmacology, 2022
Angelicae pubescentis radix (APR) has a long history in the treatment of rheumatoid arthritis (RA) in China. It has the effects of dispelling wind to eliminate dampness, removing arthralgia and stopping pain in the Chinese Pharmacopeia, but its mechanisms was unclear.
Jin Li, Yan-Xu Chang
exaly   +3 more sources

Therapeutic effects of columbianadin from Angelicae Pubescentis radix on the progression of collagen-induced rheumatoid arthritis by regulating inflammation and oxidative stress

Journal of Ethnopharmacology, 2023
Angelicae pubescentis radix (APR) has a long history in the treatment of rheumatoid arthritis (RA) in China. It has the effects of dispelling wind to eliminate dampness, removing arthralgia and stopping pain in the Chinese Pharmacopeia, but its mechanisms was remained unclear.
Shujing, Chen, Yuan, Wang, Lei, Zhang, Yuli, Han, Chunxiao, Liang, Shuangqi, Wang, Lina, Qi, Xiaoli, Pang, Jin, Li, Yanxu, Chang   +9 more
exaly   +3 more sources

Inhibition of airway inflammation by the roots of Angelica decursiva and its constituent, columbianadin

Journal of Ethnopharmacology, 2014
The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for the clinical use of Angelica decursiva and to
Hun Jai Lim, Jae-Sue Choi, Sang Kook Lee
exaly   +3 more sources

Tissue distribution study of columbianadin and its active metabolite columbianetin in rats

Biomedical Chromatography, 2015
AbstractColumbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies. In this study, a valid and sensitive reverse‐phase high‐performance liquid chromatography (RP‐HPLC) method was established and validated for the
You-Bo, Zhang, Xiu-Wei, Yang
openaire   +2 more sources

Columbianadin suppresses glioblastoma progression by inhibiting the PI3K-Akt signaling pathway

Biochemical Pharmacology
Glioblastoma (GBM) is the most common malignant glioma among brain tumors with low survival rate and high recurrence rate. Columbianadin (CBN) has pharmacological properties such as anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. However, it remains unknown that the effect of CBN on GBM cells and its underlying molecular
Wei, Zhang, Jianhong, Dong, Jiayun, Xu, Yiming, Qian, Danni, Chen, Ziwei, Fan, Hao, Yang, Jianglei, Xiang, Xiumin, Xue, Xuan, Luo, Yuanyuan, Jiang, Yongjie, Wang, Zhihui, Huang   +12 more
exaly   +3 more sources