Results 81 to 90 of about 252 (108)

Small-molecule probes based on natural products: Elucidation of drug-target mechanisms in stroke. [PDF]

open access: yesJ Pharm Anal
Jin X   +8 more
europepmc   +1 more source

Tissue distribution study of columbianadin and its active metabolite columbianetin in rats

open access: yesBiomedical Chromatography, 2016
Columbianadin, one of the main bioactive constituents of the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan, has been found to possess obvious pharmacological effects in previous studies.
You-Bo Zhang, Xiu-Wei Yang
exaly   +4 more sources

Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro

open access: yesPhytochemistry, 2012
Columbianadin (CBN, 1), 1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethyl-[(2Z)-2-methyl-2-butenoic acid jester is a coumarin-type compound and one of the main bioactive constituents of the underground part of Angelica pubescens ...
You-Bo Zhang, Xiu-Wei Yang
exaly   +4 more sources
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Therapeutic effects of columbianadin from Angelicae Pubescentis radix on the progression of collagen-induced rheumatoid arthritis by regulating inflammation and oxidative stress

Journal of Ethnopharmacology, 2023
Angelicae pubescentis radix (APR) has a long history in the treatment of rheumatoid arthritis (RA) in China. It has the effects of dispelling wind to eliminate dampness, removing arthralgia and stopping pain in the Chinese Pharmacopeia, but its mechanisms was remained unclear.
Shujing Chen   +2 more
exaly   +3 more sources

Immunosuppressive effect of Columbianadin on maturation, migration, allogenic T cell stimulation and phagocytosis capacity of TNF-α induced dendritic cells

Journal of Ethnopharmacology, 2022
Angelicae pubescentis radix (APR) has a long history in the treatment of rheumatoid arthritis (RA) in China. It has the effects of dispelling wind to eliminate dampness, removing arthralgia and stopping pain in the Chinese Pharmacopeia, but its mechanisms was unclear.
Shujing Chen   +2 more
exaly   +3 more sources

Inhibition of airway inflammation by the roots of Angelica decursiva and its constituent, columbianadin

Journal of Ethnopharmacology, 2014
The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for the clinical use of Angelica decursiva and to
Hun Jai Lim, Jae Sue Choi, Sang Kook Lee
exaly   +3 more sources

Columbianadin suppresses glioblastoma progression by inhibiting the PI3K-Akt signaling pathway

Biochemical Pharmacology
Glioblastoma (GBM) is the most common malignant glioma among brain tumors with low survival rate and high recurrence rate. Columbianadin (CBN) has pharmacological properties such as anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. However, it remains unknown that the effect of CBN on GBM cells and its underlying molecular
Zhaocai Zhang   +2 more
exaly   +3 more sources

S6K/FLNC/ITGβ3 signaling pathway regulates osteoclastogenesis and the inhibition of osteoclastogenesis by columbianadin

Phytomedicine
Over-activation of osteoclastogenesis is a significant factor contributing to bone loss, leading to increased resorption of bone. Columbianadin (CBN), a compound derived from Angelicae Pubescentis Radix, has traditionally been used in Chinese medicine to treat bone-related disorders.
Xiu-Mei Gao
exaly   +3 more sources

Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages

Phytomedicine
Traumatic synovitis often arises from sports injuries, and early intervention is crucial for preserving joint health. Columbianadin (CBN), a natural phytochemical, has demonstrated efficacy in inhibiting inflammatory progression through Chinese herbal injection therapy; however, its underlying mechanism remains unclear.This study aims to investigate ...
Zihao Li
exaly   +3 more sources

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