Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema [PDF]
The composite physiologic index (CPI) was derived to represent the extent of fibrosis on high-resolution computed tomography (HRCT), adjusting for emphysema in patients with idiopathic pulmonary fibrosis (IPF).
Martinez, Fernando J. +13 more
core +5 more sources
Combined Pulmonary Fibrosis and Emphysema (CPFE) [PDF]
Emphysema is characterized by the permanent abnormal enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of their walls. The characteristics of emphysema do not, by definition, include thickening of the alveolar septa and fibrosis.
Keisaku Fujimoto, Yoshiaki Kitaguchi
openaire +1 more source
Combined pulmonary fibrosis and emphysema (CPFE): an entity different from emphysema or pulmonary fibrosis alone. [PDF]
Chronic obstructive pulmonary disease (COPD) and idiopathic interstitial pneumonias (IIP), with different radiological, pathological, functional and prognostic characteristics, have been regarded as separate entities for a long time. However, there is an increasing recognition of the coexistence of emphysema and pulmonary fibrosis in individuals.
Lin H, Jiang S.
europepmc +3 more sources
The value of CT for disease detection and prognosis determination in combined pulmonary fibrosis and emphysema (CPFE). [PDF]
Several imaging-based indices were constructed quantitatively using the emphysema index (EI) and fibrosis score (FS) on high-resolution computed tomography (HRCT). We evaluated the ability of these indices to predict mortality compared to physiologic results.
Choi SH +7 more
europepmc +5 more sources
Background This study aimed to analyze the literature systematically to determine the clinical characteristics and prognosis of patients with connective tissue disease (CTD) with combined pulmonary fibrosis and emphysema (CPFE) compared to those of ...
Bon San Koo +6 more
doaj +1 more source
Combined pulmonary fibrosis and emphysema (CPFE) is a common but under-recognized syndrome characterized with distinct profiles of both pulmonary fibrosis and emphysema.
Kei Kusaka +6 more
doaj +1 more source
Smoking-Related Clinical and Molecular Abnormalities in Idiopathic Pulmonary Fibrosis-Associated Pulmonary Hypertension. [PDF]
ABSTRACT Pulmonary hypertension (PH) is a frequent complication of interstitial lung diseases (ILD) that worsens morbidity and mortality. Cigarette smoking has a detrimental effect on transplant‐free survival of patients with ILD, including patients with idiopathic pulmonary fibrosis (IPF).
Zhyvylo I +7 more
europepmc +2 more sources
Combined Pulmonary Fibrosis and Emphysema: When Scylla and Charybdis Ally
Combined pulmonary fibrosis and emphysema (CPFE) is a recently recognized syndrome that, as its name indicates, involves the existence of both interstitial lung fibrosis and emphysema in one individual, and is often accompanied by pulmonary hypertension.
Marija Gredic +5 more
doaj +1 more source
Smoker's Lungs: Quo Vadis? Exploring the Shared and Individual Smoking-Related Molecular Pathways of Emphysema, Carcinoma, and Fibrosis - An Illustrative Review. [PDF]
Cigarette smoking is related to chronic epithelial injury, which represents a central initiating event in smoking‐related lung diseases: NSCLC (non‐small cell lung cancer), IPF (idiopathic pulmonary fibrosis), and emphysema. Altered lung biology and shared molecular pathways contribute to their pathogenesis.
Grgurević L +5 more
europepmc +2 more sources
Diagnosis and treatment of Combined Pulmonary Fibrosis and Emphysema (CPFE)
Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome of combination pulmonary fibrosis and emphysema which is now widely found. Clinical characteristics of the CPFE are current or former heavy smoker, predominantly male, and symptom of shortness of breath on exertion.
openaire +2 more sources

