Results 61 to 70 of about 1,188 (177)

Mortality surrogates in combined pulmonary fibrosis and emphysema [PDF]

, 2023
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) with co-existent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may associate with reduced forced vital capacity (FVC) declines compared to non-CPFE IPF patients.
Mogulkoc, Nesrin, Young, Alexandra L, Porter, Joanna C, Duncan, Mark, Wuyts, Wim A, Ahmed, Asia, Vasudev, Pardeep, Verleden, Stijn, Goos, Tinne, Moodley, Yuben, Taliani, Alessandro, Chapman, Robert, Barber, David, Janes, Sam M, Jones, Mark G, Zhao, An, van Es, Hendrik W, Taylor, Magali, van Beek, Frouke, Wells, Athol U, Veltkamp, Marcel, Tavanti, Laura, Jacob, Joseph, van Moorsel, Coline, Cross, Gary, Hopkins, Peter, Savas, Recep, Jo, Helen, Vermant, Marie, Brereton, Christopher J, De Liperi, Annalisa, Wallis, Tim JM, Pontoppidan, Katarina, Procter, Alex, Gudmundsson, Eyjolfur, Barnett, Joseph, Romei, Chiara, Nair, Arjun, Corte, Tamera J, Stewart, Iain, Alexander, Daniel C, Denneny, Emma, De Sadeleer, Laurens J   +42 more
core   +1 more source

A Case Report of Combined Pulmonary Fibrosis and Emphysema

Amrita Journal of Medicine
Combined pulmonary fibrosis and emphysema (CPFE) is an underdiagnosed condition characterized by upper lobe emphysema and lower lobe fibrosis, most often seen in male smokers.
Supriya Adiody, Vishnu Narayanan
doaj   +1 more source

An Abbreviated Assessment Tool for Detection of Pulmonary Hypertension in Patients With Interstitial Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, April 2026.
ABSTRACT Pulmonary hypertension (PH) is a major complication of interstitial lung disease (ILD) and is associated with increased morbidity and mortality. Early recognition of PH in ILD is crucial for guiding diagnostic evaluation, initiating treatment, and considering lung transplantation. The previously developed PH‐ILD Detection Tool by Parikh et al.
Chebly Dagher, David M. O'Sullivan, Harrison W. Farber, Raj Parikh   +3 more
wiley   +1 more source

A Phase 2 Study of the Safety and Tolerability of Treprostinil Palmitil Inhalation Powder in Patients With Pulmonary Hypertension Associated With Interstitial Lung Disease

Pulmonary Circulation, Volume 16, Issue 2, April 2026.
ABSTRACT Treprostinil palmitil (TP) inhalation powder (TPIP), an investigational formulation of the treprostinil prodrug TP, was designed to provide prolonged pulmonary vasodilation with once‐daily administration. In this phase 2 study (NCT05176951), adults with pulmonary hypertension associated with interstitial lung disease (PH‐ILD) were randomized 3:
Colin Church, Maria Molina‐Molina, Miguel Arias‐Guillén, Patrick Muchmore, Ben R. Lavon, Jan De Backer, Natalya Makulova, Bipin Mistry, Jia Guo, Jasmanda Wu, Junaideen Fahumy, Ariel Teper, Peng‐Liang Zhao, Kevin C. Mange, Gerald O'Brien   +14 more
wiley   +1 more source

GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis

Histopathology, Volume 88, Issue 3, Page 698-709, February 2026.
We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Fatime Szalai, Judit Pápay, Katalin Dezső, Levente Kuthi, Anna Sebestyén, András Khoór, Ildikó Krencz   +6 more
wiley   +1 more source

Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective

Monaldi Archives for Chest Disease, 2015
Chronic obstructive pulmonary disease (that includes emphysema) results in significant morbidity and mortality worldwide. Idiopathic pulmonary fibrosis (IPF) is also a chronic and progressive parenchymal lung disease with an average survival of less than
I.B. Oliva, F. Cortopassi, C.L. Rochester, A.N. Rubinowitz   +3 more
doaj   +1 more source

Subcutaneous Treprostinil in PH Associated With Left Heart Disease or Chronic Lung Disease

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Pulmonary hypertension (PH) associated with left heart disease (LHD‐PH) and pulmonary hypertension associated with chronic lung disease (CLD‐PH) are the most common PH subtypes but lack effective treatments. In a prospective cohort study, 90 patients (39 LHD‐PH, 51 CLD‐PH) with severe disease [pulmonary vascular resistance (PVR) > 5 Wood units
Roela Sadushi‐Koliçi, Leila Alajbegovic, Vladimir Gojic, Nika Skoro‐Sajer, Ioana Campean, Inbal Shafran, Deddo Mörtl, Christian Gerges, Irene M. Lang   +8 more
wiley   +1 more source

The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema

Pulmonary Medicine, 2012
The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution ...
Shigeki Chiba, Hiromitsu Ohta, Kyoko Abe, Shu Hisata, Shinya Ohkouchi, Yasushi Hoshikawa, Takashi Kondo, Masahito Ebina   +7 more
doaj   +1 more source

Relationship of Pulmonary Artery to Aorta Ratio With Pulmonary Vascular Resistance, Compliance, and Outcomes in COPD and Interstitial Lung Disease in PVDOMICS

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Noninvasive imaging markers may be helpful in identifying higher‐risk patients with various lung diseases. Pulmonary artery to aorta ratio (PA/A ratio) on computed tomography (CT) is an indicator of pulmonary hypertension, but its relationship with other hemodynamic, imaging, and physiologic measurements, functional status, and outcomes ...
Matthew D. Jankowich, Matthew Borgia, Jason Lempel, Elena Desanti, Rahul Renapurkar, Alan R. Morrison, Gaurav Choudhary, Sharon I. Rounds   +7 more
wiley   +1 more source

Pulmonary Venous Vasculopathy in Connective Tissue Disease‐Associated Pulmonary Arterial Hypertension With Reduced Diffusion Capacity for Carbon Monoxide

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
In CTD‐PAH, severely reduced DLco is associated with greater small pulmonary venous stenosis and worse survival, providing quantitative morphometric evidence that DLco serves as a practical marker of venous involvement within the established PVOD‐like spectrum.
Shinya Fujisaki, Ryotaro Asano, Hiroyuki Endo, Atsushi Kuraishi, Ryo Takano, Hiroya Hayashi, Keiko Ohta‐Ogo, Kinta Hatakeyama, Kenichi Tsujita, Teruo Noguchi, Takeshi Ogo   +10 more
wiley   +1 more source