Results 91 to 100 of about 1,981,264 (328)
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, EarlyView.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
Ecography, EarlyView.Species diversity typically increases from higher to lower latitudes, but the regional‐scale variation along this geographic gradient remains unclear. It has been suggested that species diversity throughout Amazonia generally increases westward toward the Andes, but this pattern and its environmental determinants require further investigation for most ...
Pilar L. Maia‐ Braga +14 more
wiley +1 more source
Genomic instability in patients with type 2 diabetes mellitus on hemodialysis
Revista Brasileira de Hematologia e Hemoterapia, 2012 OBJECTIVE: A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay.
Roberta Passos Palazzo +4 more
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal +14 more
wiley +1 more source
DNA damage in buccal cells in oral PMDs and malignant disorders by comet assay
Brazilian Journal of Oral Sciences, 2019 Aim: DNA damage associated with Oral Squamous Cell Carcinoma (OSCC) and potentially malignant disorders (PMDs) is produced due to carcinogenic agents or increased oxidative stress. Comet assay can assist in early detection and evaluation of the amount of
Garima Rawat +3 more
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten +15 more
wiley +1 more source
Detection of Hypoxia in Human Brain Tumor Xenografts Using a Modified Comet Assay
Neoplasia: An International Journal for Oncology Research, 2003 We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but ...
Jingli Wang +8 more
doaj +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl +14 more
wiley +1 more source