Results 91 to 100 of about 1,931,388 (325)

A Study of Cytogenetic Stability of Induced Pluripotent Stem Cells Using Karyotyping and Comet Assay Techniques [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Induced pluripotent stem cells (iPSCs) have the capability to undergo unlimited selfrenewal and differentiation into all cell types in the body.
Payam Ghasemi-Dehkordi, Mehdi Allahbakhshian-Farsani, Narges Abdian, Hamideh Jafari-Ghahfarokhi, Javad Saffari-Chaleshtori, Marzieh Sadeghiani, Amin Mirzaeian, Morteza Hashemzadeh-Chaleshtori   +7 more
doaj  

Sperm DNA damage output parameters measured by the alkaline Comet assay and their importance

Andrologia, 2017
The alkaline Comet assay has shown high diagnostic value to determine male reproductive health and prognostic ability to predict ART success. Here, spermatozoon was analysed in 47 fertile donors and 238 patients, including 132 couples undergoing ART ...
L. Simon, K. Aston, B. Emery, J. Hotaling, D. Carrell   +4 more
semanticscholar   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Genomic instability in patients with type 2 diabetes mellitus on hemodialysis

Revista Brasileira de Hematologia e Hemoterapia, 2012
OBJECTIVE: A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay.
Roberta Passos Palazzo, Pamela Brambilla Bagatini, Patrícia Brandt Schefer, Fabiana Michelsen de Andrade, Sharbel Weidner Maluf   +4 more
doaj   +1 more source

Antitumor and Cytogenotoxic Activities of Libidibia ferrea Hydroalcoholic Extracts in Murine Breast Carcinoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Breast cancer is the most prevalent cancer type among women worldwide, and there is a critical need for more effective and safer treatments, especially for aggressive and therapy‐resistant subtypes. Libidibia ferrea, a native plant from Brazil, exhibits anti‐inflammatory, antimicrobial, antioxidant, and antitumor properties.
Diego Pereira de Menezes, Evaldo dos Santos Monção Filho, Atanara Alves de Sousa, João Pedro Alves Damasceno do Lago, Karla Darlianny Mourão Cavalcante, Fernanda Alves de Sousa Cavalcante, Irismara Sousa Silva, Marina Pinto Sanches, Semiramis Jamil Hadad do Monte, Ester Miranda Pereira, Paulo Michel Pinheiro Ferreira, Joao Marcelo de Castro e Sousa, Gerardo Magela Vieira Júnior, Dalton Dittz   +13 more
wiley   +1 more source

Intensifying Electrochemical Hydrocarboxylation of Activated Alkenes

ChemElectroChem, EarlyView.
The intensification of electrochemical hydrocarboxylation reaction employing a spinning cylinder electrode reactor is presented. The optimized system provides high reaction scale for the synthesis of valuable compounds, incorporating CO2 gas in organic molecules in an efficient way.
Andreas Baumgartner, Nikola Petrović, C. Oliver Kappe, Gabriele Laudadio   +3 more
wiley   +1 more source

DNA damage in buccal cells in oral PMDs and malignant disorders by comet assay

Brazilian Journal of Oral Sciences, 2019
Aim: DNA damage associated with Oral Squamous Cell Carcinoma (OSCC) and potentially malignant disorders (PMDs) is produced due to carcinogenic agents or increased oxidative stress. Comet assay can assist in early detection and evaluation of the amount of
Garima Rawat, Aadithya B Urs, Anita Chakravarti, Priya Kumar   +3 more
doaj   +1 more source

UV–Vis Spectra of Carbonic Acid: Rationalizing Experimental Redshifts between Monomer and Bulk based on (H2CO3)n Calculations

ChemPhysChem, EarlyView.
In bulk carbonic acid (e.g., in interstellar icy dust grains) cluster formation produces two distinct UV‐Vis spectral features redshifted by ≈2 eV (25 nm) and by ≈5 eV (80 nm) compared to gas phase single molecule carbonic acid 's adiabatic ionization energy. Theory and experiment were used to investigate the origin of these shifts.
Dennis F. Dinu, Bastian Klein, Chaojiang Zhang, Radu A. Talmazan, Thomas Loerting, Hinrich Grothe, Ralf I. Kaiser, Maren Podewitz   +7 more
wiley   +1 more source

Overestimation of nanoparticles-induced DNA damage determined by the comet assay

Nanotoxicology, 2016
The increasing use of engineered nanoparticles (NPs) in a wide range of commercial products raises concern about the possible risks that NPs pose to human health.
Daniela Ferraro, Umberto Anselmi-Tamburini, I. Tredici, V. Ricci, P. Sommi   +4 more
semanticscholar   +1 more source

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

Drug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel, Sylvia E. Escher, Emanuel Weiler, Anke Londenberg, Uwe Deppenmeier, Rhys Whomsley   +5 more
wiley   +1 more source