Results 111 to 120 of about 58,125 (347)

Cellular Reference Materials for DNA Damage Using Electrochemical Oxidation

Journal of Nucleic Acids, 2020
Reference materials are needed to quantify the level of DNA damage in cells, to assess sources of measurement variability and to compare results from different laboratories.
Donald H. Atha, Omobola Cole, Breece Clancy, Alessandro Tona, Vytas Reipa   +4 more
doaj   +1 more source

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]

, 2018
Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi, Colapietro, Alessandro, Cristiano, Loredana, Delle Monache, Simona, Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mehrling, Thomas, Pompili, Simona, Tombolini, Vincenzo, Vetuschi, Antonella, Vitale, Flora   +12 more
core   +2 more sources

Toxicological Evaluation of the Undesirable Components in Processed Infant Foods Using Artificial Intelligence

Future Postharvest and Food, EarlyView.
The detection of toxins in baby food using artificial intelligence. ABSTRACT Infant foods and baby formulas are becoming increasingly popular across the globe owing to their ease of consumption and nutritional value specific to infants. Impurities may find their way into the food chain at any point from the acquisition of raw materials to final ...
Poornima Singh, Anurag Singh, Ashutosh Upadhyay, Navneet Kumar   +3 more
wiley   +1 more source

A Study of Cytogenetic Stability of Induced Pluripotent Stem Cells Using Karyotyping and Comet Assay Techniques [PDF]

Journal of Kerman University of Medical Sciences, 2015
Background & Aims: Induced pluripotent stem cells (iPSCs) have the capability to undergo unlimited selfrenewal and differentiation into all cell types in the body.
Payam Ghasemi-Dehkordi, Mehdi Allahbakhshian-Farsani, Narges Abdian, Hamideh Jafari-Ghahfarokhi, Javad Saffari-Chaleshtori, Marzieh Sadeghiani, Amin Mirzaeian, Morteza Hashemzadeh-Chaleshtori   +7 more
doaj  

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
A Collins, A Cougnoux, AO Brachmann, BR Stern, Bradley S. Moore, CA Brotherton, CA Brotherton, CM Woo, D Payros, E Buc, EP Balskus, EP Rogakou, G Cuevas-Ramos, G Sharon, HB Bode, I Cho, J Chen, JA Stubbe, JC Arthur, Jennifer Y. H. Lai, Jie Li, JK Nicholson, JP Nougayrède, KJ Humphreys, KK Khanna, KS Chaturvedi, L Zha, L Zha, LB Schultz, LC Colis, LF Povirk, M Olier, M Pitie, MI Vizcaino, MI Vizcaino, MR Wilson, MS Donia, MS Donia, MS Melvin, N Bossuet-Greif, N Bossuet-Greif, NS Guntaka, P Engel, P Tripathi, Pei-Yuan Qian, RM Bleich, RM Burger, S Borah, S Tomkovich, Shaun M. K. McKinnie, T Faïs, T Pérez-Berezo, T Secher, TC Holmes, V Bondarev, Wei-Peng Zhang, Wenjun Zhang, Wenlong Cai, X Bian, X Bian, Y Pommier, YA Chan, Z-R Li, Z-R Li, Zhong-Rui Li   +64 more
core   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Cross-Sectional Multicenter Biomonitoring Study on Genotoxicity and Oxidative DNA Damage in Oncology Healthcare Workers from Seven Italian Hospitals

Journal of Xenobiotics
Cancer cases have been estimated that will increase in the next years with consequent increase of antineoplastic (AD) drug treatments and workers handling these hazardous chemicals.
Cinzia Lucia Ursini, Giorgia Di Gennaro, Giuliana Buresti, Raffaele Maiello, Anna Maria Fresegna, Aureliano Ciervo, Marco Gentile, Virginia Di Basilio, Sabrina Beltramini, Daniela Gaggero, Nicoletta Rigamonti, Erica Maccari, Giorgia Zorzetto, Piera Maiolino, Pasquale Di Filippo, Maria Concetta Bilancio, Paolo Baldo, Valeria Martinello, Andrea Di Mattia, Chiara Esposito, Patrizia Nardulli, Mariarita Laforgia, Maria Vittoria Visconti, Matteo Vitali, Emanuela Omodeo-Salè, Delia Cavallo   +25 more
doaj   +1 more source

Modelling the comet assay [PDF]

BMC Systems Biology, 2007
Darragh G. McArt, Robert W. Cairns, Gillian Wasson, Kurt Saetzler   +3 more
openaire   +1 more source

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

Journal of Applied Toxicology, EarlyView.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara, Carlina Leila Colussi, Lucía Magdalena Odetti, Damián Marino, María Fernanda Simoniello   +4 more
wiley   +1 more source

Genotoxicity assessment in estuarine environments using oyster hemocytes: a comparative comet assay study

Ocean and Coastal Research
The comet assay with sentinel organisms has been employed to determine the genotoxicity of water samples for environmental risk or hazard assessment. Methodologies with diverse sensitivities have been proposed to elucidate the sources of genetic damage,
Clovis Lira da Rocha-Júnior, Luis Fernando Carvalho-Costa, Mateus Brandão Marques, Adalto Bianchini, Ricardo Luvizotto-Santos   +4 more
doaj   +1 more source