Results 111 to 120 of about 850,969 (288)

Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity

Journal of Applied Toxicology, EarlyView.
ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara, Carlina Leila Colussi, Lucía Magdalena Odetti, Damián Marino, María Fernanda Simoniello   +4 more
wiley   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Detection of Hypoxia in Human Brain Tumor Xenografts Using a Modified Comet Assay

Neoplasia: An International Journal for Oncology Research, 2003
We used the standard comet assay successfully to generate in vitro dose-response curves under oxic and hypoxic conditions. We then made mixtures of cells that had been irradiated with 3 and 9 Gy of X-rays to simulate two subpopulations in a tumor, but ...
Jingli Wang, Jack Klem, Jan B. Wyrick, Tomoko Ozawa, Erin Cunningham, Jay Golinveaux, Max J. Allen, Kathleen R. Lamborn, Dennis F. Deen   +8 more
doaj   +1 more source

Comet assay på Saccharomyces cerevisiae: Comet assay on Saccharomyces cerevisiae [PDF]

, 2007
The purpose of this project is to clarify whether Saccaromyces cerevisiae (bakers yeast) can be used as a model for Mytilus edulis (blue mussel) in association with investigation of DNA damage. S.
Kolstrup, Johan, Wennermark, Henrik, Axelsen, Lykke Vils, Selmer, Ulrik, Dahl, Rasmus, Kimer, Anine Svendsen   +5 more
core  

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Citogenotoxic response of juvenile cobia Rachycentron canadum (Linnaeus, 1766) reared in two different systems

Brazilian Journal of Oceanography
Aquaculture production is continuously growing worldwide, and marine fish farming in Brazil is still in its infancy. Intensive farming conditions may cause physiological stress to the cultured organism, which can be evaluated by citogenotoxic biomarkers.
Marina Tenório Botelho, Maria José de Arruda Campos Rocha Passos, Fabio Matsu Hasue, Daniel Lemos, Edson Rodrigues, Fanny Yasumaru, Ngan van Phan, Vicente Gomes   +7 more
doaj   +1 more source

The application of comet assay in monitoring of the immunosuppression level in a patient with toxic epidermal necrolysis: A case report

Burns Open, 2017
Toxic epidermal necrolysis (TEN) represents the most serious affection within the SCARs group (Severe Cutaneous Adverse Reactions). It is an autoimmune disease manifested by extensive epidermal and mucosal exfoliation.
B. Lipový, M. Matejovičová, H. Řihová, D. Štikarovská, L. Novotná, M. Hlaváčová, H. Paulová, I. Suchánek, P. Brychta   +8 more
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Outcomes of periodontal therapy: Strengthening the relevance of research to patients. A co‐created review

Periodontology 2000, EarlyView., 2023
Abstract Periodontitis is a long‐term condition affecting up to half of the population globally and causing significant impacts on life quality. Successful management depends on taking life‐long ownership of the condition by those affected. There is a wealth of research to inform on management options. However, most of the research has been designed by
Ian Needleman, Neil Almond, Natalie Leow, Jim Phillips   +3 more
wiley   +1 more source

The comet assay – how to recognise “good data”

Frontiers in Genetics, 2015
Testing of potentially genotoxic materials currently involves use of in vitro assays such as the Ames test (gene mutations), the chromosome aberration assay and in vitro micronucleus assay (predominantly using human peripheral lymphocytes to detect ...
William Barfield
doaj   +1 more source