Results 101 to 110 of about 1,981,264 (328)
Burns Open, 2017 Toxic epidermal necrolysis (TEN) represents the most serious affection within the SCARs group (Severe Cutaneous Adverse Reactions). It is an autoimmune disease manifested by extensive epidermal and mucosal exfoliation.
B. Lipový +8 more
doaj +1 more source
, 2020 Stilbenes are a group of chemicals characterized with the presence of 1,2-diphenylethylene. Previously, our group has demonstrated that synthesized (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) possesses potential chemopreventive activity specifically inducing NAD(P)H:quinone oxidoreductase 1 (NQO1) protein expression and ...
Huan Huan Tan +3 more
openaire +1 more source
Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li +7 more
wiley +1 more source
Brazilian Journal of OceanographyAquaculture production is continuously growing worldwide, and marine fish farming in Brazil is still in its infancy. Intensive farming conditions may cause physiological stress to the cultured organism, which can be evaluated by citogenotoxic biomarkers.
Marina Tenório Botelho +7 more
doaj +1 more source
The comet assay – how to recognise “good data”
Frontiers in Genetics, 2015 Testing of potentially genotoxic materials currently involves use of in vitro assays such as the Ames test (gene mutations), the chromosome aberration assay and in vitro micronucleus assay (predominantly using human peripheral lymphocytes to detect ...
William Barfield
doaj +1 more source
A Systematic Mapping Review of Core Outcome Reporting in Surgical Research for Oesophageal Cancer
Journal of Surgical Oncology, EarlyView.ABSTRACT Oesophageal carcinoma is a rising global health burden, with surgical resection and perioperative chemotherapy forming the cornerstone of curative treatment. However, uncertainty persists regarding the optimal surgical approach, partly due to heterogeneity in outcome reporting, which hinders data synthesis and evidence‐based decision‐making ...
Nadia Matias +7 more
wiley +1 more source
Protein glycosylation in lung cancer from a mass spectrometry perspective
Mass Spectrometry Reviews, EarlyView.Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi +2 more
wiley +1 more source
The use of comet assay in plant toxicology: recent advances
Frontiers in Genetics, 2015 The systematic study of genotoxicity in plants induced by contaminants and other stress agents has been hindered to date by the lack of reliable and robust biomarkers.
Conceição LV Santos +2 more
doaj +1 more source
The Comet Assay in Human Biomonitoring
, 2013 Human biomonitoring studies aim to identify potential exposures to environmental, occupational, or lifestyle toxicants in human populations and are commonly used by public health decision makers to predict disease risk. The Comet assay measures changes in genomic stability and is one of the most reliable biomarkers to indicate early biological effects ...
Anderson, Diana +2 more
openaire +4 more sources
HMGB1 Assists in Overcoming Cisplatin Resistance in Chemoresistant Human Ovarian Cancer Cells
Molecular Carcinogenesis, EarlyView.ABSTRACT Cisplatin is one of the most effective chemotherapeutic agents used in the treatment of ovarian cancer. However, the frequent development of cisplatin resistance remains a significant limitation, leading to therapeutic failure and poor patient outcomes.
Van Huynh +3 more
wiley +1 more source