Results 101 to 110 of about 57,805 (348)

OpenComet: An automated tool for comet assay image analysis

Redox Biology, 2014
Reactive species such as free radicals are constantly generated in vivo and DNA is the most important target of oxidative stress. Oxidative DNA damage is used as a predictive biomarker to monitor the risk of development of many diseases.
Benjamin M. Gyori, Gireedhar Venkatachalam, P.S. Thiagarajan, David Hsu, Marie-Veronique Clement   +4 more
doaj   +1 more source

The comet assay in nanotoxicology research

Analytical and Bioanalytical Chemistry, 2010
Nanoscale particles can have impressive and useful characteristics, but the same properties may be problematic for human health. From this perspective it is critical to assess the ability of nanoparticles to cause DNA damage. This review focuses on the use of the comet assay in nanotoxicology research.
Karlsson, Hanna L.
openaire   +2 more sources

The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress [PDF]

, 2015
The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/
A Dupre, A Gulino, A Kuzyk, A Shibata, A Soriani, A Wey, A Wey, AM Duursma, AM Taylor, B Argenti, B Ricci, B Shiotani, BR Stanton, C Bruhn, C Heil, CJ Thiele, CL Marcelis, D Dominguez-Sola, D Fruci, DW Felsher, EA Rahal, F Sardina, G Giannini, G Giannini, H van Bokhoven, HE Bryant, I Screpanti, J Buis, J Charron, J Lafrance-Vanasse, J Wu, K Schlacher, K Trenz, KA Cole, KH Chrzanowska, KK To, L Di Marcotullio, LJ Valentijn, M Cognet, M Murga, M Petroni, M Petroni, M Sahún-Roncero, M Wilda, M Wojewodzka, O Chayka, P Khongkow, PE Neiman, PJ Hurlin, PO Frappart, PS Knoepfler, R Moser, R Thompson, R Waltes, RS Williams, RV Pusapati, S Albini, S Biton, S Ray, S Rohban, S Sawai, S Ying, SV Srinivasan, TG Oliver, TH Stracker, V Colicchia, V Veschi, V Veschi, W Lutz, YC Chiang, YL Lin   +70 more
core   +1 more source

Skeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs

The Anatomical Record, EarlyView.
Abstract Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.
Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann   +6 more
wiley   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Evaluation of genotoxic activity of maleic hydrazide, ethyl methane sulfonate, and N-nitroso diethylamine in Tradescantia

Salud Pública de México, 2001
Objective. To assess the genotoxic activity of N-nitroso diethylamine (NDEA), maleic hydrazide (MH), and ethyl methane sulfonate (EMS) using two systems: the comet assay on nuclei from Tradescantia, and the pink mutation test on Tradescantia staminal ...
Alvarez-Moya Carlos, Santerre-Lucas Anne, Zúñiga-González Guillermo, Torres-Bugarín Olivia, Padilla-Camberos Eduardo, Feria-Velasco Alfredo   +5 more
doaj  

Cellular Reference Materials for DNA Damage Using Electrochemical Oxidation

Journal of Nucleic Acids, 2020
Reference materials are needed to quantify the level of DNA damage in cells, to assess sources of measurement variability and to compare results from different laboratories.
Donald H. Atha, Omobola Cole, Breece Clancy, Alessandro Tona, Vytas Reipa   +4 more
doaj   +1 more source

Comet and micronucleus assays do not correlate extent of DNA damage with clinical staging of oral cavity squamous cell carcinoma [PDF]

, 2020
Andreza Negreli Santos, Rodrigo Juliano Oliveira, Lucas Roberto Pessatto, Albert Schiavetto Souza, Andréia Conceição Milan Brochado Antoniolli‐Silva, Andréa Luiza Cunha‐Laura, Maria Margarida Morena Domingos Levenhagen, Carlos Alberto Ferreira de Freitas   +7 more
openalex   +1 more source

TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]

, 2015
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi, Chen, Pin-Hsi, Hwang, Tom, Nelson, Christian R   +3 more
core   +1 more source

A Robust Bioprocess for the Global Incorporation of Noncanonical Amino Acids in Auxotrophic Hosts Produces Labeled Proteins at the Gram Scale

ChemBioChem, EarlyView.
A robust bioprocess enables global incorporation of noncanonical amino acids in both shake flask and bioreactor cultures, producing gram‐per‐liter titers of efficiently labeled proteins. A versatile Escherichia coli BL21(DE3) auxotroph platform supports broad compatibility with various noncanonical amino acids and target proteins, facilitating flexible
Patrik Fladischer, Niklaus Anderhuber, Octavian Murgu, Altijana Hromić‐Jahjefendić, Tea Pavkov‐Keller, Karl Gruber, Juergen Mairhofer, Gerald Striedner, Birgit Wiltschi   +8 more
wiley   +1 more source