Results 101 to 110 of about 51,303 (237)
Fatherhood and sperm DNA damage in testicular cancer patients [PDF]
, 2018 Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility.
Lenzi, Andrea +3 more
core +1 more source
Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li +7 more
wiley +1 more source
Effects of lentiviral vectors on DNA damage of human dermal fibroblasts (HDFs) [PDF]
, 2015 In present study we evaluated the DNA damages and cytogenetic stability of transducted and non-transducted human dermal fibroblasts (HDFs) by enhanced green fluorescent protein (eGFP) lentiviral vector using karyotyping, comet assay, and molecular ...
Abdian, Narges. +7 more
core
Uptake and toxicity studies of poly-acrylic acid functionalized silicon nanoparticles in cultured mammalian cells [PDF]
, 2012 Poly-acrylic acid (PAAc) terminated silicon nanoparticles (SiNPs) have been synthesized and employed as a synchronous fluorescent signal indicator in a series of cultured mammalian cells: HHL5, HepG2 and 3T3-L1.
Alsharif +59 more
core +1 more source
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar +4 more
wiley +1 more source
Brazilian Journal of OceanographyAquaculture production is continuously growing worldwide, and marine fish farming in Brazil is still in its infancy. Intensive farming conditions may cause physiological stress to the cultured organism, which can be evaluated by citogenotoxic biomarkers.
Marina Tenório Botelho +7 more
doaj +1 more source
The comet assay – how to recognise “good data”
Frontiers in Genetics, 2015 Testing of potentially genotoxic materials currently involves use of in vitro assays such as the Ames test (gene mutations), the chromosome aberration assay and in vitro micronucleus assay (predominantly using human peripheral lymphocytes to detect ...
William Barfield
doaj +1 more source
Reference cells and ploidy in the comet assay [PDF]
, 2015 In the comet assay single cells are analyzed with respect to their level of DNA damage. Discrimination of the individual cell or cell type based on DNA content, with concomitant scoring of the DNA damage, is useful since this may allow analysis of ...
Brunborg, Gunnar +4 more
core +2 more sources
Ce‐LLMs: Status and trends of education‐specific large language models developed in China
Future in Educational Research, EarlyView.Abstract The prevalence of AI hallucination in general‐purpose large language models (LLMs) poses significant pedagogical challenges, particularly in terms of content credibility and reliability. In response, China has launched the development of education‐specific LLMs as a national strategic initiative. However, current reports on Chinese educational
Tao Xie, Yingli Zhou, Jiazhen Yu
wiley +1 more source
The use of comet assay in plant toxicology: recent advances
Frontiers in Genetics, 2015 The systematic study of genotoxicity in plants induced by contaminants and other stress agents has been hindered to date by the lack of reliable and robust biomarkers.
Conceição LV Santos +2 more
doaj +1 more source