Results 161 to 170 of about 53,849 (278)

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, EarlyView.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

Comet Assay Profiling of FLASH-Induced Damage: Mechanistic Insights into the Effects of FLASH Irradiation. [PDF]

Int J Mol Sci, 2023
Cooper CR, Jones DJL, Jones GDD, Petersson K.   +3 more
europepmc   +1 more source

A core outcome set and reporting checklist for research on critically ill obstetric patients: An international consensus study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
An international, multi‐method consensus process identified 10 core outcomes, 7 reporting items, and 4 noncore outcomes to standardize outcome reporting, reduce heterogeneity, and improve comparability and patient‐centeredness of research on critically ill obstetric patients.
Tiffany Yeretsian, Julien Viau‐Lapointe, Rizwana Ashraf, Rohan D'Souza, Stephen E. Lapinsky   +4 more
wiley   +1 more source

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials. [PDF]

Front Toxicol, 2022
El Yamani N, Rundén-Pran E, Collins AR, Longhin EM, Elje E, Hoet P, Vinković Vrček I, Doak SH, Fessard V, Dusinska M.   +9 more
europepmc   +1 more source

Patients', clinicians' and research's priorities on important outcomes in multiple myeloma: A mixed‐methods study

British Journal of Haematology, EarlyView.
Summary Research in multiple myeloma increasingly relies on surrogate end‐points to expedite approvals, yet these may not reflect patient priorities. We conducted a mixed‐methods study to identify outcomes valued by patients and clinicians and compare them with end‐points used in randomized controlled trials (RCTs).
Maria Mainou, Thomas Karagiannis, Eirini Pagkalidou, Aris Liakos, Panagiotis Malandrakis, Evdoxia Hatjiharissi, Sofia Chissan, Evdokia Mandala, Oliver Van Oekelen, Efthymia Vlachaki, Maria Papaioannou, Evangelos Terpos, Ghulam Rehman Mohyuddin, Apostolos Tsapas   +13 more
wiley   +1 more source

Comparing P53 expression and genome-wide transcriptome profiling to Comet assay in lymphocytes from melanoma patients and healthy controls. [PDF]

Sci Rep, 2023
Najafzadeh M, Naeem P, Ghaderi N, Jafarinejad S, Karimi Z, Ghaderi M, Akhbari P, Ghaderi R, Farsi P, Wright A, Anderson D.   +10 more
europepmc   +1 more source

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source

Assay conditions for estimating differences in base excision repair activity with Fpg-modified comet assay. [PDF]

Cell Biol Toxicol, 2023
Zheng C, Collins A, Brunborg G, van Schooten FJ, Nordengen AL, Shaposhnikov S, Godschalk R.   +6 more
europepmc   +1 more source

Development of a set of core outcome measures for ambulant children with cerebral palsy after lower limb orthopaedic surgery

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To develop consensus on a core set of standardized outcome measures to be applied to each domain of the previously developed core outcome set for lower limb orthopaedic surgery for ambulant children with cerebral palsy (CP). Method This work consisted of the following three steps: (1) a scoping review of the literature to identify ...
Hajar Almoajil, Sally Hopewell, Helen Dawes, Francine Toye, Rakhshan Kamran, Tim Theologis   +5 more
wiley   +1 more source

The Comet Assay in Drosophila: A Tool to Study Interactions between DNA Repair Systems in DNA Damage Responses In Vivo and Ex Vivo. [PDF]

Cells, 2023
Rodríguez R, Gaivão I, Aguado L, Espina M, García J, Martínez-Camblor P, Sierra LM.   +6 more
europepmc   +1 more source