Results 251 to 260 of about 57,805 (348)

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

Optimized protocol for single-cell isolation and alkaline comet assay to detect DNA damage in cells of Drosophila wing imaginal discs. [PDF]

STAR Protoc
Pederzolli M, Barion E, Valerio A, Cuda AV, Manara V, Bellosta P.   +5 more
europepmc   +1 more source

Single‐Cell Nucleus Extraction with Cellular Indexing

Advanced Science, Volume 12, Issue 46, December 11, 2025.
VacTrap is a multilayer, high‐throughput microfluidic system that isolates and spatially indexes single nuclei from hundreds of cells within minutes. Using dissolvable hydrogel trapdoors triggered by chemical and vacuum actuation, VacTrap synchronously transfers nuclei while preserving spatial links to parent cells.
Trinh Lam, Ana Esmeralda Gomez Martinez, Alison Su, Anna Fomitcheva‐Khartchenko, Xin Wang, Md Nazibul Islam, Paul Lum, Amy Elizabeth Herr   +7 more
wiley   +1 more source

The Comet Assay as a Tool in Human Biomonitoring Studies of Environmental and Occupational Exposure to Chemicals-A Systematic Scoping Review. [PDF]

Toxics
Ladeira C, Møller P, Giovannelli L, Gajski G, Haveric A, Bankoglu EE, Azqueta A, Gerić M, Stopper H, Cabêda J, Tonin FS, Collins A.   +11 more
europepmc   +1 more source

The comet assay: ready for 30 more years [PDF]

, 2017
Peter Möller
openalex   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Comparison of the genotoxicity of propofol and desflurane using the comet assay in the lymphocytes of patients who underwent lumbar discectomy: A randomized trial. [PDF]

Saudi Med J
Toker MK, Altiparmak B, Gursoy G, Uysal AI, Dede G, Gundogdu G, Dodurga Y, Ugur B.   +7 more
europepmc   +1 more source

A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells [PDF]

, 2013
Atsushi Kimura, Atsuro Miyata, M. Honma
openalex   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay. [PDF]

Int Arch Occup Environ Health
Evenden P, Vandoolaeghe Q, Lecluse Y, Gac AC, Delépée R, Weiswald LB, Boutet-Robinet E, Boulanger M, Bonassi S, Lebailly P, Meryet-Figuière M.   +10 more
europepmc   +1 more source