Results 291 to 300 of about 1,931,388 (325)
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The Liverbeads® as a tool for the comet assay
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2002Liverbeads, cryopreserved hepatocytes entrapped within an alginate matrix, were examined for their relevance in the comet assay. It was estimated by their capacity to activate the indirectly acting mutagens, cyclophosphamide (CP), benzo[a]pyrene (BP), dimethylbenzanthracene (DMBA) and 2-acetylaminofluorene (2-AAF), into DNA reactive metabolites.
Ayda T Yusuf +3 more
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Environmental Pollution
The paper provides the first assessment of the occurrence of hormetic dose responses using the Comet assay, a genotoxic assay. Using a priori evaluative criteria based on the Hormetic Database on peer-reviewed comet assay experimental findings, numerous examples of hormetic dose responses were obtained.
Edward J. Calabrese, Paul B. Selby
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The paper provides the first assessment of the occurrence of hormetic dose responses using the Comet assay, a genotoxic assay. Using a priori evaluative criteria based on the Hormetic Database on peer-reviewed comet assay experimental findings, numerous examples of hormetic dose responses were obtained.
Edward J. Calabrese, Paul B. Selby
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The Comet Assay in Clinical Practice
Acta Oncologica, 1999The comet assay is a single-cell gel electrophoresis technique that measures DNA damage in individual cells. Since radiation produces 3-4 times more DNA damage in well-oxygenated cells compared with hypoxic cells, this assay can quantify the fraction of radiation-resistant hypoxic cells found in many solid tumours.
Ma R +9 more
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The Comet Assay in Marine Animals
2019Comet assay is a quick and versatile technique for assessing DNA damage in individual cells. It allows for the detection of DNA single- and double-strand breaks, as well as the presence of alkali labile sites and cross-links. Here we describe protocols for the single-cell gel electrophoresis (Comet assay) in its alkaline (pH > 13), mild alkaline (pH ...
Guidi, Patrizia +2 more
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Comet assay and early apoptosis
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001The comet assay is a single cell gel electrophoresis test currently used as a qualitative and quantitative genotoxicity test. However, some of the results from this comet assay and current knowledge on apoptosis lead us to suspect the presence of some false positive results.
G Dorange +4 more
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Comet assay in neonatal sepsis
The Indian Journal of Pediatrics, 2010To determine whether the DNA damage detected using the Comet assay helps in the diagnosis of neonatal sepsisSepsis was diagnosed, based on clinical findings, laboratory findings and positive culture results, in 24 of the 48 newborns who participated in the study.
Rozilda Lopes de Souza +3 more
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Stochastic modeling for the COMET-assay [PDF]
, 2003 We present a stochastic model for single cell gel electrophoresis (COMET-assay) data. Essential is the use of point process structures, renewal theory and reduction to intensity histograms for further data analysis.
Boulesteix, Anne-Laure +2 more
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Recent applications of the Comet Assay: A report from the International Comet Assay Workshop 2019
Toxicology Letters, 2020The International Comet Assay Workshops (ICAW) are a series of scientific conferences dealing with different aspects of the comet assay. The assay itself is a simple method for the detection of DNA strand breaks at the cellular level and can be applied to any cell type derived from different organs and tissues of eukaryotic organisms. Additionally, the
Aliy Zhanataev +3 more
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The comet assay: a comprehensive review
Mutation Research/Reviews in Genetic Toxicology, 1995The comet assay is a sensitive and rapid method for DNA strand break detection in individual cells. Its use has increased significantly in the past few years. This paper is a review of the studies published to date that have made use of the comet assay.
Kim L. O'Neill +2 more
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Acellular comet assay: a tool for assessing variables influencing the alkaline comet assay
Radiation Protection Dosimetry, 2011In this study, an acellular modification to the alkaline comet assay to further evaluate key variables within the assay that may influence the outcome of genotoxicity studies is described. This acellular comet assay can detect differences of 0.2 Gy of (60)Co gamma-ray radiation between 0 and 1 Gy and differences of 1 Gy between 0 and 8 Gy; thus, this ...
Diana Wilkinson +4 more
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