Results 61 to 70 of about 51,303 (237)

Investigation of Genotoxic Effect of Desflurane and Sevoflurane on Periferic Lymphocyte with Comet Assay Method

Haseki Tıp Bülteni, 2016
Aim: There are several clinical and cytogenetic studies that anesthetics cause choromosomal changes. We report data on the possible genotoxic properties of two inhalational anaesthetics, sevoflurane and desflurane in lymphocytes of children evaluated for
Yeşim Işıkçı, Ayşe Çiğdem Tütüncü, Pınar Kendigelen, Serpil Çakmakkaya, Fatiş Altındaş, Güner Kaya   +5 more
doaj   +1 more source

Tailored Crystallization Dynamics for Efficient and Stable DMSO‐Free Tin Perovskite Solar Cells

Advanced Science, EarlyView.
In this work, the authors investigated the crystallization process of tin perovskites in a DMSO‐free solvent system using in situ PL technique. The authors discovered that a synergistic approach effectively facilitates the formation of high‐quality DMSO‐free tin perovskite films by modulating the emergence of crystallites and the aggregation process ...
Shengnan Zuo, Alexander Tarasov, Lennart Frohloff, Karunanantharajah Prashanthan, Florian Ruske, Mailis Lounasvuori, Chiara Frasca, André Dallmann, Fengshuo Zu, Florian Mathies, Florian Scheler, Noor Titan Putri Hartono, Guixiang Li, Jinzhao Li, Maxim Simmonds, Wenhui Li, Norbert Koch, Steve Albrecht, Meng Li, Eva Unger, Mahmoud Hussein Aldanmasy, Artem Musiienko, Antonio Abate   +22 more
wiley   +1 more source

Comparing the alkaline comet with 53BP1 immunocytochemistry assay: sensitivity and cost/time effectiveness

Frontiers in Genetics, 2015
Both the comet and p53-binding protein 1 (53BP1) Immunocytochemistry (ICC) assays are well known, sensitive techniques to determine DNA damage, albeit with different perspectives.
Rajan Maynard, David Parkinson
doaj   +1 more source

Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success [PDF]

, 2010
Mammalian spermatozoa undergo a strong selection process along the female tract to guarantee fertilization by good quality cells, but risks of fertilization with DNA-damaged spermatozoa have been reported.
Ahmadi, Andrabi, Barroso, Baumber, Beirao, Cabrita, Evenson, Flajshans, Fortier, Hakem, Hales, Holt, Hu, Irvine, J Beirão, Jalabert, Jaroudi, Lee, Li, Liao, M P Herráez, Maluszynska, Matsuda, S Martínez-Páramo, S Pérez-Cerezales, Satake, Schulte, Singh, Sun, Tam, Tarin, Yeates   +31 more
core   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Evaluation of DNA damage induced by perfluorooctanoic acid using acellular, cellular, and in vivo comet assays

Zhongguo shipin weisheng zazhi, 2023
ObjectiveTo examine perfluorooctanoic acid （PFOA）-induced DNA damage using a combined in vivo and in vitro experiment.MethodsAcellular nuclear DNA damage was used as a model to test the damage induced by exposure to 0.00， 0.13， 0.25， and 0.50 mmol/L PFOA
WANG Qian, XU Tongguang, WANG Tianwei, CHEN Huihui, ZHANG Wenzhong   +4 more
doaj   +1 more source

Relation between DNA damage measured by comet assay and OGG1 Ser326Cys polymorphism in antineoplastic drugs biomonitoring [PDF]

, 2015
Antineoplastic drugs are hazardous chemical agents used mostly in the treatment of patients with cancer, however health professionals that handle and administer these drugs can become exposed and develop DNA damage.
Brito, Miguel, Carolino, Elisabete, Gomes, Manuel C., Ladeira, Carina, Pádua, Mário, Viegas, Susana   +5 more
core   +3 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

LiCoO2 particles used in Li-ion batteries induce primary mutagenicity in lung cells via their capacity to generate hydroxyl radicals

Particle and Fibre Toxicology, 2020
Background Li-ion batteries (LIB) are used in most portable electronics. Among a wide variety of materials, LiCoO2 (LCO) is one of the most used for the cathode of LIB.
Violaine Sironval, Vittoria Scagliarini, Sivakumar Murugadoss, Maura Tomatis, Yousof Yakoub, Francesco Turci, Peter Hoet, Dominique Lison, Sybille van den Brule   +8 more
doaj   +1 more source

The Development and Validation of the Smell‐Qx Questionnaire, Based on a Systematic Review of the Literature and the COMET Initiative on the Development of Core Outcome Sets for Clinical Trials in Olfactory Disorders

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction affects up to 22% of the population. Accurate assessment is vital for diagnosis and tracking outcomes, often using patient‐reported outcome measures (PROMs). Aims We aimed to develop and validate a novel questionnaire for assessing olfactory and gustatory dysfunction.
Matt Lechner, Alexander Fjaeldstad, Umar Rehman, Jacklyn Liu, David Boniface, Jim Boardman, Duncan Boak, Aytug Altundag, Johannes Frasnelli, Simon Gane, Eric Holbrook, Julien Hsieh, Caroline Huart, Iordanis Konstantinidis, Basile N. Landis, Valerie J. Lund, Alberto Macchi, Eri Mori, Christian Mueller, Joaquim Mullol, Simona Negoias, Zara M. Patel, Jayant M. Pinto, Sophia Poletti, Vijay Ramakrishnan, Philippe Rombaux, Jan Vodicka, Antje Welge‐Luessen, Katherine L. Whitcroft, Carol Yan, Carl Philpott, Thomas Hummel   +31 more
wiley   +1 more source