Results 51 to 60 of about 8,069 (192)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, EarlyView.
What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source

Late Pebble Accretion of Comet 81P/Wild 2 Nucleus: Evidence from a Plagioclase-bearing Chondrule Fragment, Pyxie

The Astrophysical Journal
Comet 81P/Wild 2 is a ∼4.5 km-sized primordial object that almost has not been modified by internal heating by ^26 Al decay. Its nucleus could have been formed by hierarchical agglomeration or gravitational collapse of pebble swarms concentrated by ...
Mingming Zhang, Michael E. Zolensky, Kohei Fukuda, Daisuke Nakashima, Michael K. Weisberg, Noriko T. Kita   +5 more
doaj   +1 more source

The Evolution of Activity and Chemical Composition in Rosetta’s Comet Targets across Multiple Apparitions: Complications for CS2 as the CS Parent in Comet Nuclei

The Planetary Science Journal, 2023
Jupiter-family comets are ephemeral small bodies injected into the inner solar system from the Kuiper Belt, doomed to either sublimate all their volatiles and become inert or violently shatter from the activity.
John W. Noonan, Joel Wm. Parker, Walter M. Harris, Steven Bromley, Mohammad Saki, Youssef Moulane, Davide Farnocchia, Marco Micheli, Jian-Yang Li, Kathleen E. Mandt, Kumar Venkataramani, Dennis Bodewits   +11 more
doaj   +1 more source

Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4‐Mediated Ferroptosis

Small, EarlyView.
ABSTRACT Pancreatic cancer, one of the most malignant solid tumors with the poorest prognosis, is commonly treated with gemcitabine (GEM)‐based systemic chemotherapy. However, chemoresistance remains a significant therapeutic challenge. Ferroptosis, a novel form of programmed cell death, has demonstrated exceptional susceptibility in chemoresistant ...
Jiaqiang Ren, Shuai Wu, Tong Su, Hugang Li, Jiachun Ding, Fan Chen, Jiantao Mo, Jie Li, Zheng Wang, Liang Han, Zheng Wu   +10 more
wiley   +1 more source

Multiple Outbursts of Halley-type Comet 12P/Pons–Brooks

The Astronomical Journal
We present optical observations of the Halley-type comet 12P/Pons–Brooks (12P) on its approach to perihelion. The comet was active even in the first observations at ∼8 au.
David Jewitt, Jane Luu
doaj   +1 more source

First Assessment of Genetic Damage in the Speckled Cockroach (Nauphoeta cinerea) After Consumption of Lettuce (Lactuca sativa) Cultivated and Commercialized in Northeastern, Brazil

Environmental Toxicology, EarlyView.
ABSTRACT This study reports, for the first time, the use of the speckled cockroach Nauphoeta cinerea as a promising bioindicator for genotoxic monitoring. It was validated through control groups (both positive and negative) in addition to testing lettuce (Lactuca sativa ) samples from public street markets consumed by N. cinerea specimens in Pernambuco,
Aleson Aparecido da Silva, Eduardo Henrique da Silva Melo, Érima Maria de Amorim, Maria Gislaine Pereira, Claudia Rohde   +4 more
wiley   +1 more source

Optimization of Neutral Comet Assay for studying DNA double-strand breaks in pea and wheat [PDF]

Journal of BioScience and Biotechnology, 2013
This study describes an adaptation of the Comet assay under neutral conditions for mono- and dicotyledonous plants pea (Pisum sativum L.) and wheat (Triticum aestivum L.).
Ivelina Nikolova, Mariyana Georgieva, Lubomir Stoilov, Zornica Katerova, Desisslava Todorova   +4 more
doaj  

The alkaline comet assay used in evaluation of genotoxic damage of drinking water disinfection by-products (bromoform and chloroform)

Frontiers in Genetics, 2015
The alkaline comet assay (pH 12.3) is a useful method for monitoring genotoxic effects of environmental pollutants in the root nuclei of Allium cepa and various plants; it allows the detection of single- and double-strand breaks, incomplete excision ...
Messaouda Khallef, Recep Liman, İbrahim Hakkı Ciğerci, Muhsin Konuk   +3 more
doaj   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source